Utilization of crossmatch techniques for renal transplantation

Current Opinion in Nephrology and Hypertension

Volumn 7, Issue 6, 1998, Pages 687-690

  Harmer, Andrea W ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXICITY; FLOW CYTOMETRY; GRAFT REJECTION; HIGH RISK POPULATION; HLA MATCHING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; STANDARDIZATION; TECHNIQUE;

HISTOCOMPATIBILITY TESTING; HUMANS; KIDNEY TRANSPLANTATION; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0031795715     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199811000-00011     Document Type: Review

References (22)

1. Patel R, Terasaki PI. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 1969; 280:735-739.
2. Leavey SF, Walshe JJ, O'Neill D, Atkins N, Donohoe J, Hickey D, Carmody M. Renal transplantation performed across a positive crossmatch: a single centre experience. Irish J Med Sci 1997; 166:245-248. A recent study which finds, as have previous studies, that positive crossmatches due to immunoglobulin M are not a contra-indication for transplantation.
3. Garovoy MR, Rheinschmidt MA, Bigos M, Perkins H, Colombe B. Flow cytometry analysis: a high technology crossmatch technique facilitating transplantation. Transplant Proc 1983; 15:1939-1944.
4. Cook DJ, Terasaki PI, Iwaki Y, Terashita GY, Lau M. An approach to reducing early kidney transplant failure by flow cytometry crossmatching. Clin Transplant 1987; 1:253-256.
5. Kotb M, Russel W, Ohman M, Hathaway D, Gaber AO. Clinical implications of flow cytometry B-cell crossmatching in renal transplantation. Transplant Proc 1997; 29:1430-1432.
6. De Carvalho Bittencourt M, Saint-Hilier Y, Chabod J, Dupont I, Chalopin JM, Herve P, Tiberghien P. B-cell flow-cytometry crossmatch: influence in renal transplantation. Transplant Proc 1997; 29:1456-1457.
7. Ogura K, Terasaki PI, Johnson C, Mendez R, Rosenthal JT, Ettenger R, et al. The significance of a positive flow cytometry crossmatch test in primary kidney transplantation. Transplantation 1993; 56:294-298.
8. Kimball P, Rhodes C, King A, Fisher R, Ham J, Posner M. Flow crossmatching identifies patients at risk for postoperative elaboration of cytotoxic antibodies. Transplantation 1998; 65:444-446. A study of pre-and post-transplant crossmatching in primary transplant recipients which clearly distinguishes between T-cell and B-cell flow cytometric crossmatches and their relative clinical significance.
9. Utzig MJ, Blumke M, Wolff-Vorbeck G, Lang H, Kirste G. Flow cytometry cross-match: a method for predicting graft rejection. Transplantation 1997; 63:551-554. The authors present an interesting discussion on the use of crossmatching results in determining the immunosuppressive protocol to be followed.
10. Abe M, KawaiT, Futatsuyama K, Tanabe K, Fuchinoue S, Teraoke S, et al. Postoperative production of anti-donor antibody and chronic rejection in renal transplantation. Transplantation 1997; 63:1616-1619. A study that shows antibody involvement in chronic rejection in live donor transplants.
11. Christiaans MHL, Overhof-de Roos R, Nieman F, van Hooff JP, van den Berg-Loonen EM. Donor-specific antibodies after transplantation by flow cytometry. Relative change in fluorescence ratio most sensitive risk factor for graft survival. Transplantation 1998; 65:427-433. A well presented study in which the importance of pre-and post-transplant crossmatch results are considered. The authors clearly show that increases in antibody levels which fall below a defined positive cut-off may still be of clinical significance.
12. Sumitran-Karuppan S, Lindholm A, Moller E. Fewer acute rejection episodes and improved outcome in kidney-transplanted patients with selection criteria based on crossmatching. Transplantation 1992; 53:666-673.
13. Fuller TC. Monitoring of HLA alloimmunisation: analysis of HLA alloantibodies in the serum of prospective transplant recipients. Clin Lab Med 1991; 11:551-570.
14. Cicciarelli J, Helstab K, Mendez R. Flow cytometry PRA, a new test that is highly correlated with graft survival. Clin Transplant 1992; 6:159-164.
15. Harmer AW, Sutton M, Bayne A, Vaughan RW, Welsh KI. A highly sensitive, rapid screening method for the detection of antibodies directed against HLA class I and II antigens. Transplant Int 1993; 6:277-280.
16. Buelow R, Mercier I, Glanville L, Regan J, Ellington L, Janda G, et al. Detection of panel-reactive anti-HLA class I antibodies by enzyme-linked immunosorbent assay or lymphocytotoxicity. Hum Immunol 1995; 44:1-11.
17. Harmer AW, Heads AJ, Vaughan RW. Detection of HLA class I and class II-specific antibodies by flow cytometry and PRA-STAT screening in renal transplant recipients. Transplantation 1997; 63:1828-1832. A study that demonstrates the greater sensitivity of flow cytometric and ELISA screening techniques for detection of HLA class I and II specific antibodies.
18. Worthington JE, Thomas AA, Dyer PA, Martin S. Detection of HLA-specific antibodies by PRA-STAT and their association with transplant outcome. Transplantation 1998; 65:121-125.
19. Feucht HE, Lederer SR, Kluth B. Humoral of renal alloreactivity in recipients of renal allografts as a risk factor for the development of delayed graft function. Transplantation 1998; 65:757-758. The association of antibodies detected by flow cytometry with deposition of complement components in renal capillaries supports the involvement of a humoral component in delayed graft function.
20. Harmer AW, Garner S, Bell AE, Anyanwu C, Cavanagh G, Culkin J, et al. Evaluation of the flow cytometric crossmatch. Preliminary results of a multicentre study. Transplantation 1996; 61:1108-1111.
21. Shenton BK, Bell AE, Harmer AW, Boyce M, Briggs D, Cavanagh G, et al. Importance of methodology in the flow cylometric crossmatch: a multicentre study. Transplant Proc 1997; 29:1454-1455.
22. Scornik JC, Bray RA, Pollack MS, Cook DJ, Marrari M, Duquesnoy R, Langley JW. Multicenter evaluation of the flow cytometry T-cell crossmatch. Results from the American Society of Histocompatibility and Immunogenetics - College of American Pathologists proficiency testing program. Transplantation 1997; 63:1440-1445.