Role and mechanism of endothelin-B receptors in mediating ET-1-induced vasoconstriction in pig skin

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 275, Issue 4 44-4, 1998, Pages

  Pang, Cho Y ^a,b,c   Zhang, Jianrong ^a   Xu, Huai ^a   Lipa, Joan E ^a,b   Forrest, Christopher R ^a,b   Neligan, Peter C ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

L type calcium channels; Phospholipase C; Protein kinase C; Skin vasoconstriction

Indexed keywords

CALCIUM CHANNEL; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; PHOSPHOLIPASE C; PROTEIN KINASE C;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN BLOOD FLOW; SKIN FLAP; SWINE;

EID: 0031793984     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.275.4.r1066     Document Type: Article

References (43)

1. Arai, H., S. Hori, I. Aramori, H. Ohkubo, and S. Nakanishi. Cloning and expression of a cDNA encoding an endothelin receptor. Nature 348: 730-732, 1990.
2. Aramosi, I., and S. Nakanishi. Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells. J. Biol. Chem. 267: 12468-12474, 1992.
3. Bathal, M. N., H. Hata, K. Matsuka, O. Ito, H. Matsuda, Y. Yoshida, and Y. T. Kawazol. Reduction of progressive burn injury by using a new non-selective endothelin-A and endothelin-B receptor antagonist. TAK-044: an experimental study in rats. Plast. Reconstr. Surg. 99: 1610-1619, 1997.
4. Becker, A., E. B. Dowdle, U. Hechler, K. Kauser, P. Donner, and W. D. Schleuning. Bitrotoxin, a novel member of the endothelin/sarafotoxin peptide family, from the venom of the burrowing asp Atractaspis bibroni. FEBS Lett. 315: 100-103, 1993.
5. Bdolah, A., Z. Wolberg, G. Fleminger, and E. Kochva. SRTX-d, a new native peptide of the endothelin/sarafotoxin family. FEBS Lett. 251: 1-3, 1989.
6. Brain, S. D., J. R. Tippins, and T. J. Williams. Endothelin induces potent microvascular constriction. Br. J. Pharmacol. 95: 1005-1007, 1988.
7. Cirino, M., E. Martin, M. Yano, and I. W. Rodger. Cardiovascular and renal actions of the endothelins receptor in pigs. J. Cardiovasc. Pharmacol. 29: 701-712, 1997.
8. 21: development of endothelin-B receptor selective antagonists. J. Med. Chem. 38: 2809-2819, 1995.
9. Crossman, D. C., S. D. Brain, and R. W. Fuller. Potent vasoactive properties of endothelin-1 in human skin. J. Appl. Physiol. 70: 260-266, 1991.
10. Daniel, R. K., and C. L. Kerrigan. The omnipotential buttock skin flap. Plast. Reconstr. Surg. 70: 11-16, 1982.
11. A receptors in humans? Trends Pharmacol. Sci. 15: 9-11, 1994.
12. De Nucci, G., R. Thomas, P. D'Orleans-Juste, E. Antunes, C. Walker, T. D. Warner, and J. R. Vane. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc. Natl. Acad. Sci. USA 85: 9797-9800, 1988.
13. Doherty, A. M. Endothelin structure and development of receptor antagonists. In: Chemical and Structural Approaches to Related Drug Design, edited by D. B. Weiner and B. William. Boca Raton, FL: CRC, 1995, p. 85-123.
14. Douglas, S. W., G. R. Beck, Jr., J. D. Elliott, and E. H. Ohlstein. Pharmacological evidence for the presence of three distinct functional endothelin receptor subtypes in the rabbit lateral saphenous vein. Br. J. Pharmacol. 114: 1529-1540, 1995.
15. Gray, G. A., B. Löffler, and M. Clozel. Characterization of endothelin receptors mediating contraction of rabbit saphenous vein. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H959-H966, 1994.
16. B receptors cause vasoconstriction of human resistance and capacitance vessels in vivo. Circulation 92: 357-363, 1995.
17. B receptors and multiple signal transduction systems. Br. J. Pharmacol. 110: 435-441, 1993.
18. Hosoda, K., K. Nakao, H. Arai, S. Suga, Y. Ogawa, M. Mukoyama, G. Shirakami, Y. Saito, S. Nakanishi, and H. Imura. Cloning and expression of human endothelin-1 receptor cDNA. FEBS Lett. 287: 23-26, 1991.
19. Inoue, A., M. Yanagisawa, S. Kimura, Y. Kasuya, T. Miyauchi, K. Goto, and T. Masaki. The human endothelin family: three structurally and pharmacolologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. USA 86: 2863-2867, 1989.
20. Ishikawa, K., M. Ihara, K. Noguchi, T. Mase, N. Mino, T. Saeki, T. Fukuroda, T. Fukami, S. Ozaki, T. Nagase, M. Nishikie, and M. Yano. Biochemical and pharmacological profile of a potent and selective endothelin β-receptor antagonist, BQ 788. Proc. Natl. Acad. Sci. USA 91: 4892-4896, 1994.
21. 19]-endothelin-1, on the isolated blood vessels. Biochem. Biophys. Res. Commun. 212: 421-427, 1995.
22. Karne, S., C. K. Jayawickreme, and M. R. Lerner. Cloning and characterization of an endothelin-3 specific receptor (ETc receptor) from Xenopus laevi dermal melanophores. J. Biol. Chem. 268: 19126-19133, 1993.
23. Kloog, T., I. Ambar, M. Sokolovsky, E. Kochva, Z. Wolberg, and A. Bdolah. Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain. Science 242: 268-270, 1988.
24. Knock, G. A., G. Terenghi, C. B. Bunker, H. A. Bull, P. M. Dowd, and J. M. Polak. Characterization of endothelin-binding sites in human skin and their regulation in primary Raynaud's phenomenon and systemic sclerosis. J. Invest. Dermatol. 101: 73-78, 1993.
25. B receptors coexist on rabbit pulmonary artery vascular smooth muscle mediating contraction. Biochem. Biophys. Res. Commun. 196: 209-215, 1993.
26. Lawrence, E., and S. D. Brain. Big endothelin-1 and big endothelin-3 are constrictor agents in the microvasculature: evidence for the local phosphoramidon-sensitive conversion of big endothelin-1. Eur. J. Pharmacol. 233: 243-250, 1993.
27. B receptors in rat skin and an investigation of their function in the cutaneous microvasculature. Br. J. Pharmacol. 115: 840-844, 1995.
28. 1 receptor. Proc. Natl. Acad. Sci. USA 88: 3185-3189, 1991.
29. Matsuzaki, K. Effect of skin flap ischemia on plasma endothelin-1 levels. Ann. Plast. Surg. 31: 499-503, 1993.
30. B like receptors. Biochem. Biophys. Res. Commun. 184: 100-106, 1992.
31. Nakamuta, M., R. Takayanagi, Y. Sakai, S. Sakamoto, H. Hagiwara, T. Mizuno, Y. Saito, D. Hirose, M. Yamamoto, and H. Nawata. Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor. Biochem. Biophys. Res. Commun. 177: 34-39, 1991.
32. B receptors. J. Pharmacol. Exp. Ther. 271: 755-761, 1994.
33. Ogawa, Y., K. Nakao, H. Arai, O. Nakagawa, K. Hosoda, S. Suga, S. Nakanishi, and H. Imura. Molecular cloning of a non-isopeptide-selective human endothelin receptor. Biochem. Biophys. Res. Commun. 178: 248-255, 1991.
34. Pang, C. Y., C. Chiu, A. Zhong, and N. Xu. Pharmacologic intervention of skin vasospasm and ischemia necrosis in pigs. J. Cardiovasc. Pharmacol. 21: 163-171, 1993.
35. Pang, C. Y., R. Z. Yang, P. Neligan, N. Xu, C. Chiu, A. Zhong, and C. R. Forrest. Vascular effects and mechanism of action of endothelin-1 in isolated perfused pig skin. J. Appl. Physiol. 79: 2106-2113, 1995.
36. Randall, M. D., D. H. Edwards, and T. M. Griffin. Activities of endothelin-1 in the vascular network of the rabbit ear: a microangiographic study. Br. J. Pharmacol. 101: 781-788, 1990.
37. Riviere, J. E., K. F. Bowman, N. A. Monteiro-Riviere, L. P. Dix, and M. P. Carver. The isolated perfused porcine skin flap (IPPSF). Fundam. Appl. Toxicol. 7: 444-453, 1986.
38. Saida, K., Y. Mitsui, and N. Ishida. A novel peptide, vasoactive intestinal contractor of a new (endothelin) peptide family. Molecular cloning, expression and biological activity. J. Biol. Chem. 264: 14613-14616, 1989.
39. B endothelin receptor. Biochem. Biophys. Res. Commun. 178: 656-663, 1991.
40. Sakurai, T., M. Yanagisawa, Y. Takuwa, H. Miyazaki, S. Kimura, K. Goto, and T. Masaki. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature 348: 732-735, 1990.
41. B receptors mediating venous smooth muscle contraction. Biochem. Biophys. Res. Commun. 200: 627-633, 1994.
42. Takayanagi, R., K. Kitazumi, C. Takasaki, K. Ohnaka, S. Aimoto, K. Tasaka, M. Ohashi, and H. Nawata. Presence of non-selective type of endothelin receptor on vascular endothelium and its linkage to vasodilation. FEBS Lett. 282: 103-106, 1991.
43. Wenzel, R. R., G. Noll, and T. F. Lüscher. Endothelin receptor antagonists inhibit endothelin in human skin microcirculation. Hypertension 23: 581-586, 1994.