A Candida albicans chaperonin subunit (CaCct8p) as a suppressor of morphogenesis and Ras phenotypes in C. albicans and Saccharomyces cerevisiae

Microbiology

Volumn 144, Issue 11, 1998, Pages 2951-2960

  Rademacher, Felicitas ^a   Kehren, Verena ^a   Stoldt, Volker R ^a   Ernst, Joachim F ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Candida; Cct complex; Chaperonins; Dimorphism; Morphogenesis

Indexed keywords

CHAPERONIN; FUNGAL PROTEIN; GLYCOGEN; PROTEIN SUBUNIT;

ARTICLE; CANDIDA ALBICANS; FUNGAL GENETICS; GENE EXPRESSION; HEAT SENSITIVITY; MORPHOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SPOROGENESIS;

CANDIDA ALBICANS; EUKARYOTA; FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0031793782     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-144-11-2951     Document Type: Article

References (51)

1. Brandriss, M. C. (1983). Proline utilization in Saccharomyces cerevisiae: analysis of the cloned PUT2 gene. Mol Cell Biol 3, 1846-1856.
2. Cannon, R. D., Jenkinson, H. F. & Shepherd, M. G. (1992). Cloning and expression of Candida albicans ADE2 and proteinase genes on a replicative plasmid in C. albicans and in Saccharomyces cerevisiae. Mol Gen Genet 235, 453-457.
3. Christianson, T. W., Sikorski, R. S., Dante, M., Shero, J. H. & Hieter, P. (1992). Multifunctional yeast high-copy-number shuttle vectors. Gene 110, 119-122.
4. Delbrück, S. & Ernst, J. F. (1993). Morphogenesis-independent regulation of actin transcript levels in the pathogenic yeast Candida albicans. Mol Microbiol 10, 859-866.
5. Durnez, P., Pernambuco, M. B., Oris, E., Argüelles, J.-C, Mergelsberg, H. & Thevelein, J. M. (1994). Activation of trehalase during growth induction by nitrogen sources in the yeast Saccharomyces cerevisiae depends on the free catalytic subunits of cAMP-dependent protein kinase, but not on functional Ras proteins. Yeast 10, 1049-1064.
6. Fonzi, W. A. & Irwin, M. Y. (1993). Isogenic strain construction and gene mapping in Candida albicans. Genetics 134, 717-728.
7. Gavrias, V., Andrianopoulos, A., Gimeno, C. J. & Timberlake, W. E. (1996). Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth. Mol Microbiol 19, 1255-1263.
8. Gietz, R. D. & Sugino, A. (1988). New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74, 527-534.
9. Gimeno, C. J. & Fink, G. R. (1994). Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Mol Cell Biol 14, 2100-2112.
10. Gimeno, C. J., Ljungdahl, P. O., Styles, C. A. & Fink, G. R. (1992). Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68, 1077-1090.
11. Gold, S., Duncan, G., Barrett, K. & Kronstad, J. (1994). cAMP regulates morphogenesis in the fungal pathogen Ustilago maydis. Genes Dev 8, 2805-2816.
12. Johnston, M. & Davis, R. W. (1984). Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae. Mol Cell Biol 4, 1440-1448.
13. Kelly, R., Miller, A. M. & Kurtz, M. B. (1988). One-step gene disruption by cotransformation to isolate double auxotrophs in Candida albicans. Mol Gen Genet 214, 24-31.
14. Köhler, J. R. & Fink, G. R. (1996). Candida albicans strains heterozygous and homozygous in mitogen-activated protein kinase signalling components have defects in hyphal development. Proc Natl Acad Sci USA 93, 13223-13228.
15. Kron, S. J. & Gow, N. A. R. (1995). Budding yeast morphogenesis: signalling, cytoskeleton and cell cycle. Curr Opin Cell Biol 7, 845-855.
16. Kronstad, J. W. (1997). Virulence and cAMP in smuts, blasts and blights. Trends Plant Sci 2, 193-199.
17. Kübler, E., Mösch, H.-U., Rupp, S. & Lisanti, M. P. (1997). Gpa2p, a G-protein α-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism. J Biol Chem 272, 20321-20323.
18. Kubota, H., Hynes, G. & Willison, K. (1995). The chaperonin containing t-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol. Eur J Biochem 239, 3-16.
19. Laloux, I., Jacobs, E. & Dubois, E. (1994). Involvement of SRE element of Ty1 transposon in TEC1-dependent transcriptional activation. Nucleic Acids Res 22, 999-1005.
20. Leberer, E., Harcus, D., Broadbent, I. D., Clark, K. L., Dignard, D., Ziegelbauer, K., Schmidt, A., Gow, N. A. R., Brown, A. J. P. & Thomas, D. Y. (1996). Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc Natl Acad Sci USA 93, 13217-13222.
21. Leuker, C. E. & Ernst, J. F. (1994). Toxicity of a heterologous leucyl-tRNA (anticodon CAG) in the pathogen Candida albicans: in vivo evidence for non-standard decoding of CUG codons. Mol Gen Genet 245, 212-217.
22. Leuker, C. E., Sonneborn, A., Delbrück, S. & Ernst, J. F. (1997). Sequence and promoter regulation of the PCK1 gene encoding phosphoenolpyruvate carboxykinase of the fungal pathogen Candida albicans. Gene 192, 235-240.
23. Lin, P., Cardillo, T. S., Richard, L M., Segal, G. B. & Sherman, F. (1997). Analysis of mutationally altered forms of the Cct6 subunit of the chaperonin from Saccharomyces cerevisiae. Genetics 147, 1609-1633.
24. Liu, H., Styles, C. A. & Fink, G. R. (1993). Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 262, 1741-1744.
25. Liu, H., Köhler, J. & Fink, G. R. (1994). Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266, 1723-1725.
26. Lo, H.-J., Köhler, J. R., Didomenico, B., Loebenberg, D., Cacciapuoti, A. & Fink, G. R. (1997). Nonfilamentous C. albicans mutants are avirulent. Cell 90, 939-949.
27. Lorenz, M. C. & Heitman, J. (1997). Yeast pseudohyphal growth is regulated by GPA2, a G protein α homolog. EMBO J 16, 7008-7018.
28. Losberger, C. & Ernst, J. F. (1989). Sequence and transcript analysis of the C. albicans URA3 gene encoding orotidine-5′-phosphate decarboxylase. Curr Genet 16, 153-157.
29. MacMurray, A. & Shin, H.-S. (1988). The antimorphic nature of the Tc allele at the mouse T locus. Genetics 120, 545-550.
30. Madhani, H. D. & Fink, G. R. (1997). Combinatorial control required for the specificity of yeast MAPK signaling. Science 275, 1314-1317.
31. Madhani, H. D., Styles, C. A. & Fink, G. R. (1997). MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91, 673-684.
32. Miller, K. Y., Wu, J. & Miller, B. L. (1992). StuA is required for cell pattern formation in Aspergillus. Genes Dev 6, 1770-1782.
33. Mösch, H.-U., Roberts, R. & Fink, G. R. (1996). Ras2 signals via the Cdc42/Ste20/mitogen-activated kinase module to induce filamentous growth in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 93, 5352-5356.
34. Niimi, M. (1996). Dibutyryl cyclic AMP-enhanced germ tube formation in exponentially growing Candida albicans cells. Fungal Genet Biol 20, 79-83.
35. Niimi, M., Niimi, K., Tokunaga, J. & Nakayama, H. (1980). Changes in cyclic nucleotide levels and dimorphic transition in Candida albicans. J Bacterial 142, 1010-1014.
36. Odds, F. C. (1988). Candida and Candidosis. London: Baillière Tindall.
37. Ruis, H. & Schüller, C. (1995). Stress signaling in yeast. BioEssays 17, 959-965.
38. Schmidt, A., Kunz, J. & Hall, M. N. (1996). TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci USA 93, 13780-13785.
39. Schmidt, A., Bickle, M., Beck, T. & Hall, M. N. (1997). The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88, 531-542.
40. Sherman, F., Fink, G. & Hicks, J. (1986). Methods in Yeast Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
41. Singh, P., Ganesan, K., Malathi, K., Gosh, D. & Datta, A. (1994). ACPR, a STE12 homologue from Candida albicans, is a strong inducer of pseudohyphae in Saccharomyces cerevisiae haploids and diploids. Biochem Biophys Res Commun 205, 1079-1085.
42. Sternlicht, H., Farr, G. W., Sternlicht, M. L, Driscoll, J. K., Willison, K. & Yaffe, M. B. (1993). The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo. Proc Natl Acad Sci USA 90, 9422-9426.
43. Stoldt, V., Rademacher, F., Kehren, V., Ernst, J. F., Pearce, D. A. & Sherman, F. (1996). The Cct eukaryotic chaperonin subunits of Saccharomyces cerevisiae and other yeasts. Yeast 12, 523-529.
44. Stoldt, V. R., Sonneborn, A., Leuker, C. & Ernst, J. F. (1997). Efg1, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J 16, 1982-1991.
45. Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K. & Wigler, M. (1985). In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 40, 27-36.
46. Toda, T., Cameron, S., Sass, P., Zoller, M. & Wigler, M. (1987). Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50, 277-287.
47. Ursic, D., Sedbrook, J. C, Himmel, K. L & Culbertson, M. E. (1994). The essential yeast Tcp1 protein affects actin and microtubules. Mol Biol Cell 5, 1065-1080.
48. Ward, M. P., Gimeno, C. J., Fink, G. R. & Garrett, S. (1996). SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription. Mol Cell Biol 15, 6854-6863.
49. Yaffe, M. B., Farr, G. W., Miklos, D., Horwich, A. L, Sternlicht, M. L. & Sternlicht, H. (1992). TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature 358, 245-248.
50. Zahn, R., Buckle, A. M., Perrett, S., Johnson, C. M., Corrales, F. J., Golbik, R. & Fersht, A. R. (1996). Chaperone activity and structure of monomeric polypeptide binding domains of GroEL. Proc Natl Acad Sci USA 93, 15024-15029.
51. Ziman, M., O'Brien, J. M., Oullette, L. A., Church, W. R. & Johnson, D. I. (1991). Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity. Mol Cell Biol 11, 3537-3544.