메뉴 건너뛰기




Volumn 77, Issue 2, 1998, Pages 117-123

Involvement of the retinoblastoma protein in brown and white adipocyte cell differentiation: Functional and physical association with the adipogenic transcription factor C/EBPα

Author keywords

Adipocytes; C EBP ; Cell growth; Differentiation; pRB

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; DIFFERENTIATION ANTIGEN; LIPID; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR;

EID: 0031793107     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-9335(98)80079-4     Document Type: Article
Times cited : (41)

References (35)
  • 1
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254 (1976).
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 2
    • 0026050219 scopus 로고
    • Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
    • Cao, Z., R.M.Umek, S. L. McKnight: Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5, 1538-1552 (1991).
    • (1991) Genes Dev. , vol.5 , pp. 1538-1552
    • Cao, Z.1    Umek, R.M.2    McKnight, S.L.3
  • 3
    • 0027300035 scopus 로고
    • Tissue-specific and β-adrenergic regulation of the mitochondrial uncoupling protein gene: Control by cis-acting elements in the 5′-flanking region
    • Cassard-Doulcier, A. M., C. Gelly, N. Fox, J. Schrementi, S. Raimbault, S. Klaus, C. Forest, F Bouillaud, D. Ricquier: Tissue-specific and β-adrenergic regulation of the mitochondrial uncoupling protein gene: Control by cis-acting elements in the 5′-flanking region. Mol. Endocrinol. 7, 497-506 (1993).
    • (1993) Mol. Endocrinol. , vol.7 , pp. 497-506
    • Cassard-Doulcier, A.M.1    Gelly, C.2    Fox, N.3    Schrementi, J.4    Raimbault, S.5    Klaus, S.6    Forest, C.7    Bouillaud, F.8    Ricquier, D.9
  • 4
    • 0030031409 scopus 로고    scopus 로고
    • Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
    • Chen, P. L., D. J. Riley, S. Chen-Kiang, W.H.Lee: Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 93, 465-169 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 465-1169
    • Chen, P.L.1    Riley, D.J.2    Chen-Kiang, S.3    Lee, W.H.4
  • 5
    • 0029830342 scopus 로고    scopus 로고
    • Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
    • Chen, P. L., D. J. Riley, Y. Chen, W. H. Lee: Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 10, 2794-2804(1996).
    • (1996) Genes Dev. , vol.10 , pp. 2794-2804
    • Chen, P.L.1    Riley, D.J.2    Chen, Y.3    Lee, W.H.4
  • 6
    • 0024429019 scopus 로고
    • Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
    • Chen, P. L., P. Scully, J.Y.Shew, J. Y J. Wang, W. H. Lee: Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58, 1193-1198 (1989).
    • (1989) Cell , vol.58 , pp. 1193-1198
    • Chen, P.L.1    Scully, P.2    Shew, J.Y.3    Wang, J.Y.J.4    Lee, W.H.5
  • 7
    • 0024728988 scopus 로고
    • Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes
    • Christy, R. J., V. W. Yang, J. M. Ntambi, D. E. Geiman, W. M. Landschulz, A. D. Friedman, Y. Nakabeppu, T. J. Kelly, M.D.Lane: Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev. 3, 1323-1335 (1989).
    • (1989) Genes Dev. , vol.3 , pp. 1323-1335
    • Christy, R.J.1    Yang, V.W.2    Ntambi, J.M.3    Geiman, D.E.4    Landschulz, W.M.5    Friedman, A.D.6    Nakabeppu, Y.7    Kelly, T.J.8    Lane, M.D.9
  • 10
    • 0028129499 scopus 로고
    • Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells
    • Freytag, S. O., D. L. Paielli, J. D. Gilbert: Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev. 8,1654-1663(1994).
    • (1994) Genes Dev. , vol.8 , pp. 1654-1663
    • Freytag, S.O.1    Paielli, D.L.2    Gilbert, J.D.3
  • 11
    • 0027499060 scopus 로고
    • Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
    • Gu, W., J.W.Schneider, G. Condorelli, S.Kaushal, V.Mahdavi, B. Nadal-Ginard: Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72, 309-324 (1993).
    • (1993) Cell , vol.72 , pp. 309-324
    • Gu, W.1    Schneider, J.W.2    Condorelli, G.3    Kaushal, S.4    Mahdavi, V.5    Nadal-Ginard, B.6
  • 12
    • 0024398546 scopus 로고
    • A direct role for C/EBP and the AP-1-binding site in gene expression linked to adipocyte differentiation
    • Herrera, R., H. S. Ro, G. S. Robinson, K. G. Xanthopoutos, B. M. Spiegelman: A direct role for C/EBP and the AP-1-binding site in gene expression linked to adipocyte differentiation. Mol. Cell. Biol. 9, 5331-5339 (1989).
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 5331-5339
    • Herrera, R.1    Ro, H.S.2    Robinson, G.S.3    Xanthopoutos, K.G.4    Spiegelman, B.M.5
  • 13
    • 0025618980 scopus 로고
    • Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: A comparison of the "hot spot" mutant phenotypes
    • Hinds, P. W., C. A. Finlay, R. S. Quartin, S. J. Baker, E. R. Fearon, B. Volgestein, A. J. Levine: Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes. Cell Growth Differ. 1, 571-580 (1990).
    • (1990) Cell Growth Differ. , vol.1 , pp. 571-580
    • Hinds, P.W.1    Finlay, C.A.2    Quartin, R.S.3    Baker, S.J.4    Fearon, E.R.5    Volgestein, B.6    Levine, A.J.7
  • 14
    • 0026021882 scopus 로고
    • Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
    • Kaelin, W. G. Jr., D. C. Pallas, J. A. De Caprio, K. J. Kaye, D. M. Livingston: Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product. Cell 64, 521-532 (1991).
    • (1991) Cell , vol.64 , pp. 521-532
    • Kaelin Jr., W.G.1    Pallas, D.C.2    De Caprio, J.A.3    Kaye, K.J.4    Livingston, D.M.5
  • 15
    • 0028047014 scopus 로고
    • Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD
    • Kaushal, S., J. W. Schneider, B. Nadal-Ginard, V. Mahdavi: Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD. Science 266, 1236-1240 (1994).
    • (1994) Science , vol.266 , pp. 1236-1240
    • Kaushal, S.1    Schneider, J.W.2    Nadal-Ginard, B.3    Mahdavi, V.4
  • 16
    • 0026511284 scopus 로고
    • Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes
    • Lin, F. T., M. D. Lane: Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. Genes Dev. 6, 533-544 (1992).
    • (1992) Genes Dev. , vol.6 , pp. 533-544
    • Lin, F.T.1    Lane, M.D.2
  • 17
    • 0028564903 scopus 로고
    • CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program
    • Lin, F. T., M. D. Lane: CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc. Natl. Acad. Sci. USA 91, 8757-8761 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8757-8761
    • Lin, F.T.1    Lane, M.D.2
  • 18
    • 0027420920 scopus 로고
    • A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: Transcriptional activator lacking antimitotic activity
    • Lin, F. T., O. MacDougald, A. M. Diehl, M.D.Lane: A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. Proc. Natl. Acad. Sci. USA'90, 9606-9610 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9606-9610
    • Lin, F.T.1    MacDougald, O.2    Diehl, A.M.3    Lane, M.D.4
  • 19
    • 0024851254 scopus 로고
    • Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
    • Mihara, K., X. R. Cao, A. Yen, S. Chandler, B. Driscoll, A. L. Murphree, A. TAng, Y. K. T. Fung: Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product. Science 246, 1300-1303 (1989).
    • (1989) Science , vol.246 , pp. 1300-1303
    • Mihara, K.1    Cao, X.R.2    Yen, A.3    Chandler, S.4    Driscoll, B.5    Murphree, A.L.6    Tang, A.7    Fung, Y.K.T.8
  • 20
    • 0007814343 scopus 로고
    • Expression and interaction of C/EBP alpha adipogenic transcription factor and retinoblastoma protein in adipocytes during differentiation
    • Puigserver, P., B. Nadal-Ginard, A. Palou: Expression and interaction of C/EBP alpha adipogenic transcription factor and retinoblastoma protein in adipocytes during differentiation. Int. J. Obes. 18, S2, 113 (1994).
    • (1994) Int. J. Obes. , vol.18 S2 , pp. 113
    • Puigserver, P.1    Nadal-Ginard, B.2    Palou, A.3
  • 21
    • 0026642858 scopus 로고
    • Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo
    • Puigserver, P., D.Herron, M.Gianotti, A. Palou, B. Cannon, J. Nedergaard: Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Biochem. J. 284, 393-395 (1992).
    • (1992) Biochem. J. , vol.284 , pp. 393-395
    • Puigserver, P.1    Herron, D.2    Gianotti, M.3    Palou, A.4    Cannon, B.5    Nedergaard, J.6
  • 22
    • 0007820839 scopus 로고    scopus 로고
    • Involvement of the retinoblastoma protein (pRB) in adipocyte cell differentiation and thermogenesis. in vitro and in vivo interaction of pRB with the adipogenic transcription factor C/EBPct
    • Puigserver, P., M. Gianotti, B. NadaJ-Ginard, A. Palou: Involvement of the retinoblastoma protein (pRB) in adipocyte cell differentiation and thermogenesis. In vitro and in vivo interaction of pRB with the adipogenic transcription factor C/EBPct. Int. J. Obes. 20, S4, 132(1996).
    • (1996) Int. J. Obes. , vol.20 S4 , pp. 132
    • Puigserver, P.1    Gianotti, M.2    Nadaj-Ginard, B.3    Palou, A.4
  • 23
    • 0024997854 scopus 로고
    • Alfa- And beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocyte differentiation in culture
    • Rehnmark, S., M. Nŕchad, D.Herron, B. Cannon, J. Nedergaard: Alfa- and beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocyte differentiation in culture. J. Biol. Chem. 265, 16464-16471 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 16464-16471
    • Rehnmark, S.1    Nŕchad, M.2    Herron, D.3    Cannon, B.4    Nedergaard, J.5
  • 24
    • 0030942261 scopus 로고    scopus 로고
    • Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation
    • Richon, V. M., R. E. Lyle, R. E. McGehee Jr.: Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation. J. Biol. Chem. 272, 10117-10124 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 10117-10124
    • Richon, V.M.1    Lyle, R.E.2    McGehee Jr., R.E.3
  • 25
    • 0025168432 scopus 로고
    • Negative regulation of human c-fos expression by the retinoblastoma gene product
    • Robbins, P. D., J. M. Horowitz, R. C. Mulligan: Negative regulation of human c-fos expression by the retinoblastoma gene product. Nature 346, 668-671 (1990).
    • (1990) Nature , vol.346 , pp. 668-671
    • Robbins, P.D.1    Horowitz, J.M.2    Mulligan, R.C.3
  • 27
    • 0026048640 scopus 로고
    • The CCAAT/enhancer binding protein and its role in adipocyte differentiation: Evidence for direct involvement in terminal adipocyte development
    • Samuelsson, L., K. Stromberg, K.Vikman, G.Bjursell, S. Enerback: The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. EMBO J. 10, 3787-3793 (1991).
    • (1991) EMBO J. , vol.10 , pp. 3787-3793
    • Samuelsson, L.1    Stromberg, K.2    Vikman, K.3    Bjursell, G.4    Enerback, S.5
  • 28
    • 0028339957 scopus 로고
    • Reversal of terminal differentiation mediated by p107 in RIWmuscle cells
    • Schneider, J. W., W. Gu, L. Zhu, V. Mahdavi, B. Nadal-Ginard: Reversal of terminal differentiation mediated by p107 in RIWmuscle cells. Science 264, 1467-1471 (1994).
    • (1994) Science , vol.264 , pp. 1467-1471
    • Schneider, J.W.1    Gu, W.2    Zhu, L.3    Mahdavi, V.4    Nadal-Ginard, B.5
  • 29
    • 0023687042 scopus 로고
    • A simple phase-extraction assay for chlor-amphenicol acyltransferase activity
    • Seed, B., J. Y. Sheen: A simple phase-extraction assay for chlor-amphenicol acyltransferase activity. Gene 67, 271-277 (1988).
    • (1988) Gene , vol.67 , pp. 271-277
    • Seed, B.1    Sheen, J.Y.2
  • 30
    • 0027465113 scopus 로고
    • Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes
    • Spiegelman, B. M., L. Choy, G. S. Hotamisligil, R. A. Graves, P. Tontonoz: Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J. Biol. Chem. 268, 6823-6826(1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 6823-6826
    • Spiegelman, B.M.1    Choy, L.2    Hotamisligil, G.S.3    Graves, R.A.4    Tontonoz, P.5
  • 31
    • 0021029572 scopus 로고
    • Dot-blotting. A novel screening assay for antibodies in hybridoma cultures
    • Sternberg, J., P. Jeppesen: Dot-blotting. A novel screening assay for antibodies in hybridoma cultures. J. Immunol. Methods 64, 39-3 (1983).
    • (1983) J. Immunol. Methods , vol.64 , pp. 39-43
    • Sternberg, J.1    Jeppesen, P.2
  • 32
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz P., E. Hu, B. M. Spiegelman: Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79, 1147-1156 (1994).
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 33
    • 0026031601 scopus 로고
    • CCAATenhancer binding protein: A component of a differentiation switch
    • Umek, R. M., A. L. Friedman, S. L. McKnight: CCAATenhancer binding protein: a component of a differentiation switch. Science 251, 288-292 (1991).
    • (1991) Science , vol.251 , pp. 288-292
    • Umek, R.M.1    Friedman, A.L.2    McKnight, S.L.3
  • 35
    • 0028278336 scopus 로고
    • CCAAT/enhancer binding proteins alpha and beta are transcriptional activators of the brown fat uncoupling protein gene promoter
    • Yubero, P., C. Manchado, T. Mampel, O. Viñas, R. Iglesias, M. Giralt, F. Villarroya: CCAAT/enhancer binding proteins alpha and beta are transcriptional activators of the brown fat uncoupling protein gene promoter. Biochem. Biophys. Res. Commun. 198, 653-659(1994).
    • (1994) Biochem. Biophys. Res. Commun. , vol.198 , pp. 653-659
    • Yubero, P.1    Manchado, C.2    Mampel, T.3    Viñas, O.4    Iglesias, R.5    Giralt, M.6    Villarroya, F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.