Differential expression of progestin receptor isoforms in the hypothalamus, pituitary, and endometrium of rhesus macaques

Endocrinology

Volumn 139, Issue 2, 1998, Pages 677-687

  Bethea, Cynthia L ^a,b   Widmann, Andrea A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; MESSENGER RNA; PROGESTERONE; PROGESTERONE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOMETRIUM; FEMALE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN POLYMORPHISM; RECEPTOR DENSITY; RHESUS MONKEY;

EID: 0031792532     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.2.5752     Document Type: Article

References (62)

1. Sprangers SA, Brenner RM, Bethea CL 1989 Estrogen and progestin receptor immunocytochemistry in lactotropes vs. gonadotropes of monkey pituitary cell cultures. Endocrinology 124:1462-1470
2. Sprangers SA, West NB, Brenner RM, Bethea CL 1990 Regulation and localization of estrogen and progestin receptors in the pituitary of steroid treated monkeys. Endocrinology 126:1133-1142
3. Sprangers SA, Fahrenbach HW, Bethea CL 1991 Steroid action on estrogen and progestin receptors in monkey pituitary cell cultures. Endocrinology 128:1907-1917
4. Bethea CL, Fahrenbach WH, Sprangers SA, Freesh F 1992 Immunocytochemical localization of progestin receptors in monkey hypothalamus: effect of estrogen and progestin. Endocrinology 130:895-905
5. Bethea CL 1994 Regulation of progestin receptors in raphe neurons of steroid-treated monkeys. Neuroendocrinology 60:50-61
6. Bethea CL, Brown NA, Kohama SG 1996 Steroid regulation of estrogen and progestin receptor messenger ribonucleic acid in monkey hypothalamus and pituitary. Endocrinology 137:4372-4383
7. Cho H, Aronica SM, Katzenellenbogen BS 1994 Regulation of progesterone receptor gene expression in MCF-7 breast cancer cells: a comparison of the effects of cyclic AMP, estradiol, IGF-1 and serum factors. Endocrinology 134:658-664
8. Kraus WL, Katzenellenbogen BS 1993 Regulation of progesterone receptor gene expression and growth in the rat uterus: modulation of estrogen actions by progesterone and sex steroid hormone antagonists. Endocrinology 132:2371-2379
9. Katzenellenbogen JA, O'Malley BW, Katzenellenbogen BS 1996 Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell-and promoter-specific action of these hormones. Mol Endocrinol 10:119-131
10. Sheridan PL, Krett ML, Gordon JA, Horwitz KB 1988 Human progesterone receptor transformation and nuclear down-regulation are independent of phosphorylation. Mol Endocrinol 2:1329-1342
11. Brenner RM, and Slayden OD 1994 Cyclic changes in the primate oviduct and endometrium In: Knobil E, Neill JD (eds) The Physiology of Reproduction, ed. 2. Raven Press, Ltd., New York, pp 541-569
12. Zaino RJ, Feil PD, Clarke CL, Mortel R, Satyaswaroop PG 1989 A polyclonal antiserum against the rabbit progesterone receptor recognizes the human receptor: immunohistochemical localization in rabbit and human uterus. Cell Biochem Func 7:147-152
13. Clarke CL 1990 Cell-specific regulation of progesterone receptor in the female reproductive system. Mol Cell Endocrinol 70:C29-C33
14. Khan-Dawood FS, Dawood MY 1984 Estrogen and progesterone receptor and hormone levels in human myometrium and placenta in term pregancy. Am J Obstet Gynecol 150:501-505
15. Chandrasekher YA, Meiner MH, Nagalla SR, Stouffer RL 1994 Progesterone receptor, but not estradiol receptor, messenger ribonucleic acid is expressed in luteinizing granulosa cells and the corpus luteum in rhesus monkeys. Endocrinology 135:307-314
16. Duffy DM, Stouffer RL 1995 Progesterone receptor messenger ribonucleic acid in the primate corpus luteum during the menstrual cycle: Possible regulation by progesterone. Endocrinology 136:1869-1876
17. Hild-Petito S, Stouffer RL, Brenner RM 1988 Immunocytochemical localization of estradiol and progesterone receptors in the monkey ovary throughout the menstrual cycle. Endocrinology 123:2896-2905
18. Brenner RM, West NB, McClellan MC 1991 Localization and regulation of estrogen and progestin receptors in the macaque oviduct. Arch Biol Med Exp 24:283-293
19. Moguilewsky M, Raynaud J-P 1979 The relevance of hypothalamic and hypophyseal progestin receptor regulation in the induction and inhibition of sexual behavior in the rat. Endocrinology 105:516-522
20. Blaustein JD, Feder HH 1979 Cytoplasmic progestin receptors in female guinea pig brain and their relationship to refractoriness in expression of female sexual behavior. Brain Res 177:489-498
21. Blaustein JD, Turcotte JC 1990 Down-regulation of progestin receptors in guinea pig brain: new findings using an immunocytochemical technique. J Neurobiol 21:675-685
22. Brown TJ, Blaustein JD 1985 Loss of hypothalamic nuclear-bound progestin receptors: factors involved and the relationship to heat termination in female guinea pigs. Brain Res 358:180-190
23. Hotchkiss J, Knobil K 1994 The menstrual cycle and its neuroendocrine control. 711-750
24. Freeman ME 1994 The neuroendocrine control of the ovarian cycle of the rat. In: Knobil E, Neill JD (eds) The Physiology of Reproduction. Raven Press, New York, pp 613-658
25. Horwitz KB, Alexander PS 1983 In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation. Endocrinology 113:2195-2201
26. Conneely OM, Maxwell BL, Toft DO, Schrader WT, O'Malley BW 1987 The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA. Biochem Biophys Res Commun 149:493-501
27. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P 1990 Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 9:1603-1614
28. Meyer ME, Pornon A, Ji J, Bocquel MT, Chanbon P, Gronemeyer H 1990 Agonist and antagonist properties of RU486 on the functions of the human progesterone receptor. EMBO J 9:3923-3932
29. Bocquel MT, Kumar V, Stricker C, Chambon P, Gronemeyer H 1989 The contribution of the N-and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell specific. Nucleic Acids Res 17:2581-2894
30. Tora L, Gronemeyer H, Turcotte B, Gaub M-P, Chambon P 1988 The N-terminal region of the chicken progesterone receptor specifies target gene activation. Nature 333:185-188
31. Conneely OM, Kettleberger DM, Tsai M-J, and O'Malley BW 1989 Promoter-specific activating domains of the chicken progesterone receptor. In: Roy AK, Clark J (eds) Gene Regulation by Steroid Hormones IV. Springer-Verlag, New York, pp 220-233
32. Tung L, Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB 1993 Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol 7:1256-1265
33. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP 1993 Human progesterone receptor A form is a cell-and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol 7:1244-1255
34. McDonnell DP, Goldman ME 1994 RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. J Biol Chem 269:11945-11949
35. Wen DX, Xu Y-F, Mais DE, Goldman ME, McDonnell DP 1994 The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol Cell Biol 14:8356-8364
36. Bethea CL, Kohama SG, Widmann AA 1994 Search for progestin receptors in prolactin-releasing peptidergic neurons: oxytocin neurons lack PR but respond to gonadal steroids. Endocrinology 134:945-953
37. Beck CA, Weigel NL, Edwards DP 1992 Effects of hormone and cellular modulators of protein phosphorylation on transcriptional activity, DNA binding, and phosphorylation of human progesterone receptors. Mol Endocrinol 6:607-620
38. Wei LL, Gonzalez-Aller C, Wood WM, Miller LA, Horwitz KB 1990 5′-Heterogeneity in human progesterone receptor transcripts predicts a new amino-terminal truncated "C"-receptor and unique A-receptor messages. Mol Endocrinol 4:1833-1840
39. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
40. Greene GL, Hams K, Bova R, Kinders R, Moore B, Nolan C 1988 Purification of T47D human progesterone receptor and immunochemical characterization with monoclonal antibodies. Mol Endocrinol 2:714-726
41. Press MF, Greene GL 1988 Localization of progesterone receptor with monoclonal antibodies to the human progestin receptor. Endocrinology 122:1165-1175
42. West NB, Reselli CE, Resko JS, Greene GL, Brenner RM 1988 Estrogen and progestin receptors and aromatase activity in rhesus monkey prostate. Endocrinology 123:2312-2322
43. El-Ashry D, Onate SA, Nordeen SK, Edwards DP 1989 Human progesterone receptor complexed with the antagonist RU486 binds to hormone response elements in a structurally altered form. Mol Endocrinol 3:1545-1558
44. Mohamed MK, Tung L, Takimoto GS, Horwitz KB 1994 The leucine zippers of c-fos and c-jun for progesterone receptor dimerization; A-dominance in the A/B heterodimer. J Steroid Biochem Mol Biol 51:241-250
45. James MD, Hole DR, Wilson CA 1989 Differential involvement of 5-hydroxy-tryptamine (5HT) in specific hypothalamic areas in the mediation of steroid-induced changes in gonadotropin release and sexual behavior in female rats. Neuroendocrinology 49:561-569
46. Mani SK, Allen JMC, Clark JH, Blaustein JD, O'Malley BW 1994 Convergent pathways for steroid hormone-and neurotransmitter-induced rat sexual behavior. Science 265:1246-1249
47. Blaustein JD, Olster DH 1989 Gonadal steroid hormone receptors and social behaviors In: Balthazart J (ed) Advances in Comparative and Environmental Physiology, vol 3. Springer-Verlag, Berlin, pp 31-104
48. Mani SK, Blaustein JD, O'Malley BW 1997 Progesterone receptor function from a behavioral perspective. Horm Behav 31:244-255
49. Calderon J-J, Muldoon TB, Mahesh VB 1987 Receptor-mediated interrelationships between progesterone and estradiol action on the anterior pituitary-hypothalamic axis of the ovariectomized immature rat. Endocrinology 120:2428-2435
50. Graham JD, Yeates C, Balleine RL, Harvey SS, Milliken JS, Bilous AM, Clarke CL 1995 Characterization of progesterone receptor A and B expression in human breast cancer. Cancer Res 55:5063-5068
51. Savouret JF, Rauch M, Redeuilh G, Chauchereau A, Woodruff K, Parker MG, Milgrom E 1994 Interplay between estrogens, progestins, retinoic acid and AP-1 on a single regulatory site in the progesterone receptor gene. J Biol Chem 269:28955-28962
52. Feil PS, Clarke CL, Satyaswaroop PG 1988 Progesterone-mediated changes in progesterone receptor forms in the normal human endometrium. Endocrinology 123:2506-2513
53. Kato J, Hirata S, Nozawa A, Yamada-Mouri N 1994 Gene expression of progesterone receptor isoforms in the rat brain. Horm Behav 28:454-463
54. Duffy DM, Wells TR, Haluska GJ, Stouffer RL 1997 The ratio of progesterone receptor isoforms changes in the monkey corpus luteum during the luteal phase of the menstrual cycle. Biol Reprod 57:693-699
55. Sullivan WP, Madden BJ, McCormick DJ, Toft DO 1988 Hormone-dependent phosphorylation of the avian progesterone receptor. J Biol Chem 263:14717-14723
56. Logeat F, Le Cunff M, Pamphile R, Milgrom E 1985 The nuclear-bound form of the progesterone receptor is generated through a hormone-dependent phosphorylation. Biophys Res Commun 131:421-427
57. Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, Masushige S, Gotoh Y, Nishida E, Kawashima H, Metzger D, Chambon P 1995 Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270:1491-1494
58. Rao KVS, Peralta WD, Greene GL, Fox CF 1987 Cellular progesterone receptor phosphorylation in response to ligands activating protein kinases. Bioch Biophys Res Commun 146:1357-1365
59. Sheridan PL, Francis MD, Horwitz KB 1989 Synthesis of human progesterone receptors in T47D human breast cancer cells. Nascent A-and B-receptors are active without a phosphorylation-dependent post-translational maturation step. J Biol Chem 264:7054-7058
60. Denner LA, Weigel NL, Maxwell BL, Schrader WT, O'Malley BW 1990 Regulation of progesterone receptor-mediated transcription by phosphorylation. Science 250:1740-1743
61. Brenner RM, Maslar IA 1988 The Primate Oviduct and Endometrium In: Knobil E, Neill JD (eds) The Physiology of Reproduction, ed. 1. Raven Press, New York, pp 303-327
62. Neumann F 1978 The physiological action of progesterone and the pharmacological effects of progestins - a short review. Postgrad Med J 54:11-24