Acute effect of EtOH on Mg2+ homeostasis in liver cells: Evidence for the activation of an Na+/Mg2+ exchanger

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 275, Issue 5 38-5, 1998, Pages

  Tessman, Patrick A ^a   Romani, Andrea ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine 5' triphosphate; Perfusion; Sodium magnesium exchanger

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMILORIDE; CHOLINE; DIMETHYL SULFOXIDE; LACTATE DEHYDROGENASE; MAGNESIUM;

ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CELL COMPARTMENTALIZATION; ELECTROLYTE BALANCE; ENDOPLASMIC RETICULUM; HORMONAL REGULATION; LIVER PERFUSION; MEMBRANE FLUIDITY; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; SIGNAL TRANSDUCTION; SODIUM TRANSPORT;

EID: 0031792365     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1998.275.5.g1106     Document Type: Article

References (20)

1. 31P-NMR in vivo study. Alcohol 12: 131-136, 1995.
2. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
3. Corkey, B. E., J. Duszynski, T. L. Rich, B. Matschinsky, and J. R. Williamson. Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria. J. Biol. Chem. 261: 2567-2574, 1986.
4. De Young, M. B., G. Dubyak, and A. Scarpa. Measurement of phosphometabolites in heart and muscle by high-perfomance liquid chromatography. In: The Heart and Cardiovascular System: Scientific Foundations (2nd ed.), edited by H. A. Fozzard, E. Haber, R. B. Jennings, A. M. Katz, and H. E. Morgan. New York: Raven, 1990, vol. I, chapt. 24, p. 543-549.
5. Domschke, S., W. Domschke, and C. S. Lieber. Hepatic redox state: attenuation of the acute effects of ethanol induced by chronic ethanol consumption. Life Sci. 15: 1327-1334, 1974.
6. 2+ exchange in human red cells by its sensitivity to tricyclic antidepressant drugs. Naunyn Schmiedebergs Arch. Pharmacol. 338: 332-337, 1988.
7. Flatman, P. W., and L. M. Smith. Sodium-dependent magnesium uptake by ferret red cells. J. Physiol. (Lond.) 443: 217-230, 1991.
8. Flink, E. B. Magnesium deficiency in alcoholism. Alcohol. Clin. Exp. Res. 10: 590-594, 1986.
9. Galambos, J. T. Natural history of alcoholic hepatitis. 3. Histological changes. Gastroenterology 63: 1026-1035, 1972.
10. Gandhi, C. R., and C. H. Ross. Influence of ethanol on calcium, inositol phospholipids and intracellular signalling mechanisms. Experientia 45: 407-413, 1988.
11. Gasbarrini, A., A. M. Borle, P. Caraceni, A. Colantoni, H. Farghali, F. Trevisani, M. Bernardi, and D. H. van Thiel. Effect of ethanol on adenosine trisphosphate, cytosolic free calcium, and cell injury in rat hepatocytes: time course and effect of nutritional status. Dig. Dis. Sci. 41: 2204-2212, 1996.
12. Gonzales-Calcin, J. L., J. B. Saunders, and R. Williams. Effects of ethanol and acetaldehyde on hepatic plasma membrane ATPases. Biochem. Pharmacol. 32: 1723-1728, 1983.
13. 2+ influx. Miner. Electrolyte Metab. 19: 259-265, 1993.
14. 2+ antiport. Biochem. Biophys. Res. Commun. 130: 540-545, 1985.
15. 2+ antiporter in thymocytes by cAMP. FEBS Lett. 297: 132-134, 1992.
16. 2+ efflux from isolated perfused rat livers. Magnes. Bull. 14: 126-129, 1992.
17. Gunzel, D., and N. R. Schlue. Sodium-magnesium antiport in Retzius neurones of the leech Hirudo medicinalis. J. Physiol. (Lond.) 491: 595-608, 1996.
18. Harper, C. G., and J. J. Krill. Neuropathology of alcoholism. Alcohol Alcohol. 25: 207-213, 1990.
19. Hemmingsen, R., and P. Kramp. Effect of acute ethanol intoxication, chronic ethanol intoxication, and ethanol withdrawal on magnesium and calcium metabolism in the rat. Psychopharmacology (Berl.) 67: 255-259, 1980.
20. Hoek, J. B., A. P. Thomas, T. A. Rooney, K. Higashi, and E. Rubin. Ethanol and signal transduction in the liver. FASEB J. 6: 2386-2396, 1992.