Identification of distinct metabolic pools of aggrecan and their relationship to type VI collagen in the chondrons of mature bovine articular cartilage explants

Connective Tissue Research

Volumn 37, Issue 3-4, 1998, Pages 277-293

  Winter, Gavin M ^a   Poole, C Anthony ^b   Ilic, Mirna Z ^c   Ross, Jacqueline M ^b   Robinson, H Clem ^a   Handley, Christopher J ^c  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c LA TROBE UNIVERSITY   (Australia)

Author keywords

Aggrecan; Articular cartilage; Confocal autoradiography; Extracellular matrix; Type VI collagen

Indexed keywords

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0031791731     PISSN: 03008207     EISSN: None     Source Type: Journal    
DOI: 10.3109/03008209809002445     Document Type: Article

References (21)

1. Meachin, G. and Stockwell, R.A. (1979). The matrix. In Adult Articular Cartilage, 2nd edition (Ed. Freeman, M.A.R.). pp. 1-68. Pitman Medical Ltd, London.
2. Poole, C.A. (1993). Structure and function of articular cartilage matrices. In Joint Cartilage Degradation: Basic and Clinical Aspects (Eds. J.F. Woessner and D.S. Howell), pp. 1-35. Marcel Dekker, New York.
3. Ratcliffe, A., Fryer, P.R. and Hardingham, T.E. (1984). The distribution of aggregating proteoglycan in articular cartilage: comparison of quantitative immunoelectron microscopy with radioimmunoassay and biochemical analysis. J. Histochem. Cytochem., 32, 193-201.
4. Poole, C.A., Flint, M.H. and Beaumont, B.W. (1984). Morphological and functional interrelationships of articular cartilage matrices. J. Anat., 138, 113-138.
5. Benninghoff, A. (1925). Form und bau der gelenkknorpel in ihren beziehungen zur funktion. Zweiter teil: der aufbau des gelenkknorpels in seinen beziehungen zur funktion. Zschr. Zellforch., 2, 783-862.
6. Poole, C.A. (1990). Chondrons extracted from articular cartilage: methods and applications. In Methods in Cartilage Research. (Eds. A. Maroudas and K. Kuettner), pp. 78-83. Academic press, London.
7. Poole, C.A., Giant, T. and Schofield, J.R. (1991). Chondrons from articular cartilage (IV). Immunolocalization of proteoglycan epitopes in isolated canine tibial chondrons. J. Histochem. Cytochem., 39, 1175-1187.
8. Poole, C.A. (1992). Chondrons. The chondrocyte and its pericellular microenvironment. In Articular Cartilage and Osteoarthtritis (Eds. K.E. Kuettner, R. Schleycrbach, J.G. Peyron and V.C. Hascall), pp. 201-220. Raven Press, New York.
9. Eyre, D.R., Wu, J.-J. and Apone, S. (1987). A growing family of collagen in articular cartilage: identification of 5 genetically distinct types. J. Rheumatol., 14, 25-27.
10. Poole, C.A., Ayad, s. and Schofield, J.R. (1988). Chondrons from articular cartilage (I). Immunolocalization of type Vl collagen in the pericellular capsule of isolated canine chondrons. J. Cell Sci., 90, 635-645.
11. Ilic, M.Z., Mok, M.T., Williamson, O.D., Campbell, M.A. and Handley. C.J. (1995a). Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid. Arch. Biochem. Biophys., 322, 22-30.
12. Ilic, M.Z., Haynes, S.R., Winter, G.M. and Handley, C.J. (1995b). Kinetics of release of aggrecan from explant cultures of bovine articular cartilage from different sources and from animals of different ages. Acta Orthop. Scand., 66, 33-37.
13. Mok, S.S., Masuda, K., Hauselmann, H.J., Aydelotte, M.B. and Thonar, E.J.-M.A. (1994). Aggrecan synthesized by mature bovine ehondrocytes suspended in alginate. J. Biol. Chem., 269, 33021-33027.
14. Hascall, V.C., Handley, C.J., McQuillan, D.J., Hascall, G.K., Robinson, H.C. and Lowther, D.A. (1983). The effect of serum on biosynthesis of proteoglycans by bovine articular cartilage in culture. Arch. Biochem. Biophys., 224, 206-223.
15. Bolis, S., Handley, C.J. and Comper, W.D. (1989). Passive loss of proteoglycan from articular cartilage explants. Biochim. Biophys. Acta. 993, 157-167.
16. Farndale, R.W., Buttle, D.J. and Barrett, A.J. (1986). Improved quanlitation and discrimination of sulfated glycosaminoglycans by use of dimethylene blue. Biochim. Biophys. Acta. 883, 173-177.
17. Ilic, M.Z., Handley, C.J., Robinson, H.C. and Mok, M.T. (1991). Mechanism of catabolism of aggrecan by articular cartilage. Arch. Biochem. Biophys., 294, 115-122.
18. Sandy, J.D., O'Neil, S. and Ratzlaff, L.C. (1989). Acquisition of hyaluronate binding affinity in vivo of newly synthesized proteoglycans. Biochem. J., 258, 875-880.
19. Poole, C.A. (1997). Articular cartilage chondrons: Form, function and failure. J. Anat., 191, 1-13.
20. Bayliss, M.T. (1992). Metabolism of animal and human osteoarthritic cartilage. In Articular Cartilage and Osteoarthritis (Eds. K.E. Kuettner, R. Sehleyerbach, J.G. Peyron and V.C. Hascall). pp. 487-500. Raven Press. New York.
21. Poole, C.A., Flint, M.H. and Beaumont, B.W. (1987). Chondrons in cartilage: ultrastructural analysis of the pericellular microenvironment in adult human articular cartilage. J. Orthop. Res., 5, 509-522.