Cyclosporine A in the treatment of early rheumatoid arthritis. A prospective, randomized 24-month study

Clinical and Experimental Rheumatology

Volumn 16, Issue 6, 1998, Pages 695-701

  Drosos, A A ^a   Voulgari, P V ^a   Papadopoulos, I A ^a   Politi, E N ^a   Georgiou, P E ^a   Zikou, A K ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

Author keywords

Cyclosporine A; Early immunointervention; Methotrexate; Rheumatoid arthritis

Indexed keywords

ANTIRHEUMATIC AGENT; CYCLOSPORIN A; METHOTREXATE; PREDNISONE;

ADULT; ARTHRALGIA; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; EARLY DIAGNOSIS; FEMALE; GINGIVA HYPERPLASIA; GRIP STRENGTH; HUMAN; HYPERTENSION; HYPERTRICHOSIS; IMMUNOMODULATION; MAJOR CLINICAL STUDY; MALE; MORNING STIFFNESS; NAUSEA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; VOMITING;

ADOLESCENT; ADULT; AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; CYCLOSPORINE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; PREDNISOLONE; PROSPECTIVE STUDIES; SAFETY; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 0031791048     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. HARRIS ED JR: Mechanisms of disease: Rheumatoid arthritis-pathophysiology and implications for therapy. N EnglJ Med 1990; 322: 1277-89.
2. FIRESTEIN GS: The immunopathogenesis of rheumatoid arthritis. Curr Opin Rheumata! 1991; 3: 398-406.
3. PANAYI GS: The immunopathogenesis of rheumatoid zrthnlh.BrJRheumatol 1993; 32: 4-14.
4. REEM GH, COOK LA, VILCEK J: Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporine A. Science 1983; 221: 63-5.
5. KAIIAN BD: Drug therapy: Cyclosporine. N EnglJ Med 1989; 321: 1725-8.
6. YOCUM DE, TORLEY II: Cyclosporine A in rheumatoid arthritis. Rheum Dis Clin North Am 1995;21:835-44.
7. DOUGADOS M, AMOR B: Cyclosporine A in rheumatoid arthritis: Preliminary clinical results of an open trial. Arthritis Rheum 1987; 30:83-7.
8. YOCUM DE, KLIPPEL JH, WILDER RL et al.: Cyclosporine A in treatment of severe refractory rheumatoid arthritis. Ann Intern Med 1988; 109: 863-9.
9. VAN RIJTHOVEN AWAM, DIJKMANS BAC, GOEI THE HS et al: Cyclosporine treatment for rheumatoid arthritis: A placebo controlled double-blind multicentre study. Ann Rheum Dis 1988; 45: 726-31.
10. TUGWELL P, BOMBARDIER C, GENT M et al.: Low-dose cyclosporine versus placebo in patients with rheumatoid arthritis. Lancet 1990; 335: 1051-5.
11. VAN RIJTHOVEN AWAM, DIJKMANS BAC, GOEI THE HS et al.: Comparison of cyclo-sporine and D-penicillamine for rheumatoid arthritis: A randomized double-blind study. J Rheumatol 1991; 18:815-20.
12. FORRE 0, BJERKHOEL F, SALVESEN CFetal.: An open, controlled, randomized comparison of cyclosporine and azathioprine in the treatment of rheumatoid arthritis: A preliminary report. Arthritis Rheum 1987; 30: 88-92.
13. DERG KJ, FORRE 0, DJOSELAND O: Renal side effects of high and low cyclosporine-A doses in patients with rheumatoid arthritis. Clin Nephrol 1989; 31: 232-8.
14. FEUTREN G, MIHATSCH MJ: Risk factors for cyclosporine A induced nephropathy in patients with autoimmune diseases. N Engl J Med 1992; 326: 1654-60.
15. PANAYI OS, TUGWELL P: The use of cyclosporine A in rheumatoid arthritis: Conclusions of an international review. Br J Rheumatol 1994; 33: 967-9.
16. MIHATSCH MJ, THIEL G, RYFFEL B: Morphology of cyclosporin nephropathy. Prog Allergy 1986; 38: 447-65.
17. RODRIGUEZ F, KRAYENBUHL JC, HARISSON WB et al.: Renal biopsy findings and followup of renal function in rheumatoid arthritis patients treated %vith cyclosporine A. Arthritis Rheum 1996; 39: 1491-8.
18. BOERS M: Renal disorders in rheumatoid arthritis. Semin Arthritis Rheum 1990; 20:57-68.
19. ALTMAN RD, FEREZ GO, SFAKIANAKIS ON: Interaction of cyclosporine A and non-steroidal anti-inflammatory drugs on renal function in patients with rheumatoid arthritis. Am J Med 1992; 93:396-402.
20. WEINBLATT ME, KAPLANH, GERMAIN BF er aJ.: Methotrexate in rheumatoid arthritis: A five year prospective multi-center trial..Art/!ritis Rheum 1994; 37:1492-8.
21. ARNETT FC, EDWORTHY SM, BLOCH DA, et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthntis. Arthritis Rheum 1988; 31: 315-24.
22. STEINBROCKER O, TRAEGER CH, BATTERMAN RC: Therapeutic criteria in rheumatoid arthritis. JAMA 1949; 140: 659-62.
23. LARSEN A, DAKE K, EEK M: Radiographie evaluation of rheumatoid arthritis and related conditions by standard reference follows. Ada Radial 1977; 18:481-91.
24. FUCHS HA, KAYE JJ, CALLAHAN LF, NANCE EP, PINCUS T: Evidence of significant radiographic damage in rheumatoid arthritis within the first 2 years of disease. J Rheumatol 1989; 16:585-91.
25. VAN DER HEIDE A, JACOBS JWG, BIJLSMA JWJ et al : The effectiveness of early treatment with "second line" antirheumatic drugs: A randomized, controlled trial. Ann Intern filed 1996; 124: 699-707.
26. LANDEWÉ RBM, GOBI THE HS, VAN RIJTHOVEN AWAM, BREEDVELD FC, DIJKMANS BAC: A randomized double-blind 24-week controlled study of low-dose cyclosporine versus chlorochine for early rheumatoid arthritis./lrt/iri/is/?/!em 1994;37:637-43.
27. PASERO G, PRIOLOF, MARUBINI E et al: Slow progression of joint damage in early rheumatoid arthritis treated with cyclosporine A.. Arthritis Rheum 1996; 39:1006-15.
28. DROSOS AA, TSIFETAKI N, TSIAKOU EK et al.: Influence of methotrexate on radiographie progression in rheumatoid arthritis. A sixty month prospective study. Clin Exp Rheumatol 1997; 15: 263-7.
29. F0RRE 0 and the NORWEGIAN ARTHRITIS STUDY GROUP: Radiological evidence of disease modification in rheumatoid arthritis patients treated with cyclosporine. Arthritis Rheum 1994; 37: 1506-12.