Selecting an antidepressant by using mechanism of action to enhance efficacy and avoid side effects

Journal of Clinical Psychiatry

Volumn 59, Issue SUPPL. 18, 1998, Pages 23-29

  Stahl, Stephen M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; DESIPRAMINE; DOPAMINE UPTAKE INHIBITOR; FLUOXETINE; MIRTAZAPINE; MONOAMINE OXIDASE INHIBITOR; NEFAZODONE; NORADRENALIN UPTAKE INHIBITOR; SEROTONIN 2 ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; VENLAFAXINE;

AKATHISIA; CLINICAL FEATURE; COGNITIVE DEFECT; CONFERENCE PAPER; DEMENTIA; DEPRESSION; DRUG EFFICACY; DRUG MECHANISM; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERSOMNIA; INSOMNIA; MOTOR RETARDATION; OBESITY; PANIC; PRIORITY JOURNAL; SEIZURE; SEXUAL DYSFUNCTION; TREATMENT INDICATION;

ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BUPROPION; CYCLOHEXANOLS; DEPRESSIVE DISORDER; HUMANS; MONOAMINE OXIDASE INHIBITORS; PRESCRIPTIONS, DRUG; RECEPTORS, SEROTONIN; SEROTONIN UPTAKE INHIBITORS; TRIAZOLES;

EID: 0031788123     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Stahl SM. Basic psychopharmacology of antidepressants, 1: antidepressants have seven distinct mechanisms of action. J Clin Psychiatry. In press
2. Stahl SM. Psychopharmacology of Antidepressants. London, England: Martin Dunitz Press; 1997
3. Stimmel GL, Dopheide JA, Stahl SM. Mirtazapine: an antidepressant with noradrenergic and specific serotonergic effects. Pharmacotherapy 1997;17:10-21
4. Stahl SM. Are two antidepressant mechanisms better than one? [BRAINSTORMS] J Clin Psychiatry 1997;58:339-340
5. Stahl SM. Essential Psychopharmacology. New York, NY: Cambridge University Press; 1996
6. Richelson E. The pharmacology of antidepressants at the synapse: focus on newer compounds. J Clin Psychiatry 1994;55(suppl A)34-41
7. Stahl SM. Mechanism of action of serotonin selective reuptake inhibitors: serotonin pathways and receptors mediate therapeutic effects and side effects. J Affect Disord. In press
8. Frazer A. Pharmacology of antidepressants. J Clin Psychopharmacol 1997;17(suppl 1):2S-18S
9. Sambunaris A, Hesselink JK, Pinder R, et al. Development of new antidepressants. J Clin Psychiatry 1997;581(suppl 6):40-53
10. Nelson JC. Safety and tolerability of the new antidepressants. J Clin Psychiatry 1997;58(suppl 6):26-31
11. Stimmel GL, Sussman N, Wingard P. Mirtazapine safety and tolerability: analysis of the clinical trials database. Primary Psychiatry 1997;4:82-96
12. Stahl SM. Antidepressant combinations and augmentation strategies for difficult cases, 1: the serotonin strategy versus the classical strategies. Psychiatr Ann 1997;27:257-260
13. Stahl SM. Antidepressant combinations and augmentation strategies for difficult cases, 2: the heroic strategy. Psychiatr Ann 1997;27(11):722-724
14. Danish University Antidepressant Group. Citalopram: clinical effect profile in comparison with clomipramine: a controlled multicenter study. Psychopharmacol 1986;90:131-138
15. Danish University Antidepressant Group. Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. J Affect Disord 1990;18:289-299
16. Shader RI, Fogelman SM, Greenblatt DJ. Newer antidepressants: hypotheses and evidence [editorial]. J Clin Psychopharmacol 1997;17:1-3
17. Schatzberg AF. Treatment of severe depression with the selective serotonin reuptake inhibitors. Depression and Anxiety 1996;4:182-189
18. Miller HL, Delgado P, Salomon R. Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression. Arch Gen Psychiatry 1996;53:117-128
19. Baron BM, Ogden AM, Siegel BW. Rapid down-regulation of β-adrenoceptors by co-administration of desipramine and fluoxetine. Eur J Pharmacol 1988;154:125-134
20. Nelson JC, Mazure CM, Bowers MB. A preliminary open study of the combination of fluoxetine and desipramine for rapid treatment of major depression. Arch Gen Psychiatry 1991;48:303-307
21. Stahl SM. Selecting an antidepressant by matching patient profiles with antidepressant profiles. Psychiatr Ann 1997;27:610-612