Identification of a 57-kilodalton selenoprotein in human thyrocytes as thioredoxin reductase and evidence that its expression is regulated through the calcium-phosphoinositol signaling pathway

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 6, 1998, Pages 2052-2058

  Howie, A Forbes ^a   Arthur, John R ^b   Nicol, Fergus ^b   Walker, Simon W ^a   Beech, Stuart G ^a   Beckett, Geoffrey J ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; INOSITOL PHOSPHATE; SELENIUM; SELENOPROTEIN; THIOREDOXIN REDUCTASE;

ARTICLE; HUMAN; HUMAN CELL; LIOTHYRONINE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THYROID CELL; THYROID FUNCTION;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; CALCIMYCIN; CALCIUM; CELLS, CULTURED; HUMANS; IONOPHORES; KINETICS; PHOSPHATIDYLINOSITOLS; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; THIOREDOXIN REDUCTASE (NADPH); THYROID GLAND; THYROTROPIN;

EID: 0031787329     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.6.2052     Document Type: Article

References (34)

1. Arthur JR, Beckett GJ. 1994 Newer aspects of micronutrients in at risk groups: new metabolic roles for selenium. Proc Nutr Soc. 53:615-624.
2. Behne D, Hilmert H, Scheid S, Gessner G, Edger W. 1988 Evidence for specific selenium target tissues and new biologically important selenoproteins. Biochim Biophys Acta. 966:12-21.
3. Berry MA, Larsen PR. 1994 Selenocysteine and the structure, function and regulation of iodothyronine deiodination: update 1994. Endocr Rev. 3:265-269.
4. Beckett GJ, Arthur JR. 1994 The iodothyronine deiodinases and 5′-deiodination. Bailiere Clin Endocrinol Metab. 272:285-304.
5. Croteau W, Davey JC, Galton VA, St. Germain D. 1996 Cloning of the mammalian type II iodothyronine deiodinase. J Clin Invest. 98:405-417.
6. Adams GM, Larsen PR. 1973 Triiodothyronines and thyroxine in the serum and thyroid glands of iodine deficient rats. J Clin Invest. 52:252-253.
7. Ishii H, Inada M, Tanaka K, et al. 1983 Induction of outer and inner ring monodeiodinases in human thyroid gland by thyrotropin. J Clin Endocrinol Metab. 57:500-505.
8. Beech SG, Walker SW, Dorrance AM, et al. 1993 The role of thyroidal type 1 iodothyronine deiodinase in tri-iodothyronine production by human and sheep thyrocytes. J Endocrinol. 136:361-370.
9. Salvatore D, Tu H, Harney JW, Larsen PR. 1996 Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest. 98:962-968.
10. Bermano G, Nicol F, Dyer JA, et al. 1995 Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. Biochem J. 311:425-450.
11. Howie AF, Walker SW, Akesson B, Arthur JR, Beckett GJ. 1995 Thyroidal extracellular glutathione peroxidase: a potential regulator of thyroid hormone synthesis. Biochem J. 308:713-717.
12. Dumont JE. 1971 The action of thyrotropin on thyroid metabolism Vitam Horm. 29:287-412.
13. 2 generating system modulates protein iodination and the activity of the pentose phosphate pathway in dog thyroid. Endocrinology. 128:779-785.
14. Bjorkman U, Ekholm R. 1992 Hydrogen peroxide generation and its regulation in FRTL5 and porcine thyroid cells. Endocrinology. 130:393-399.
15. 2+ cascades in mediating the effects of thyrotropin and iodide on hormone synthesis and secretion in human thyroid slices. J Clin Endocrinol Metab. 79:152-159.
16. Goyens P, Golstein J, Nsombola B, Vis H, Dumont JE. 1987 Selenium deficiency as a possible factor in the pathogenesis of myxoedematous endemic cretinism. Acta Endocrinol (Copenh). 114:497-502.
17. Corvilain B, Contempre B, Longombe AO, et al. 1993 Selenium and the thyroid-how the relationship was established. Am J Clin Nutr. 57:S244-S248.
18. Bansal MP, Mukhopadhyay T, Scott J, Cook RG, Mukhopadhyay R, Medina D. 1990 DNA sequencing of a mouse liver protein that binds selenium: implications for selenium's mechanism of action in cancer prevention. Carcinogenesis. 11:2071-2073.
19. Lanfear J, Fleming J, Walker M, Harrison P. 1993 Different patterns of regulation of the genes encoding the closely related 56 kDa selenium and acetaminophen binding proteins in normal tissues and during carcinogensis. Carcinogenesis. 14:335-340.
20. Sinha R, Bansal MP, Ganther H, Medina D. 1993 Significance of selenium-labeled proteins for selenium's chemopreventative functions. Carcinogenesis 14:1895-1900.
21. Bassuk JA, Berg RA. 1989 Protein disulphide isomerase, a multifunctional endoplasmic reticulum protein. Matrix. 9:244-258.
22. Holmgren A, Bjornstedt M. 1995 Thioredoxin and thioredoxin reducatse. Methods Enzymol. 252:199-208.
23. Tamura T, Stadtman TC. 1996 A new selenoprotein from human lung adenocarcinoma cells: purification, properties and thioredoxin reducatse activity. Proc Natl Acad Sci USA. 93:1006-1011.
24. Gladyshev VN, Jeang K, Stadtman TC. 1996 Selenocysteine identified as the penultimate C terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proc Natl Acad Sci USA. 93:6146-6151.
25. Bjornstedt M, Hamberg M, Kumar S, Xue J, Holmgren A. 1995 Human thioredoxin reducatse directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols. J Biol Chem. 270:11761-11764.
26. Beech SG, Walker SW, Arthur JR, Lee D, Beckett GJ. 1995 Differential control of type 1 iodothyronine deiodinase expression by activation of the cyclic AMP and phosphoinosirol signalling pathways in human thyrocytes. J Mol Endocrinol. 14:171-177.
27. Towbin H, Staehlin T, Gordon J. 1979 Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA. 76:4350-4353.
28. McLeod R, Ellis EM, Arthur JR, et al. 1997 Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reducatse and glutathione S transferase subunit that metabolises the mycotoxin. Cancer Res. 57:4257-4266.
29. Bradford MM. 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principal of protein-dye binding. Anal Biochem. 72:248-254.
30. Vassart G, Dumont JE. 1992 The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 13:61-76.
31. Rasmussen H. 1986 The calcium second messenger system. N Engl J Med. 314:1164-1170.
32. Sharifi J, St Germain DL. 1992 The cDNA for the type I iodothronine deiodinase encodes an enzyme manifesting both high Km and low Km activity. Evidence that rat liver and kidney contain a single enzyme which converts thyroxine to 3,5,3′-triiodthyronine. J Biol Chem. 267:12539-12544.
33. Bjorkman U, Ekholm R. 1995 Hydrogen peroxide degradation and glutathione peroxidase activity in cultures of thyroid cells. Mol Cell Endocrinol. 111:99-107.
34. May JM, Mendiratta S, Hill KE, Burk RF. 1997 Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase. J Biol Chem. 36: 22607-22610.