Overexpression of MDM2 in acute childhood lymphoblastic leukemia

Pediatric Hematology and Oncology

Volumn 15, Issue 6, 1998, Pages 519-526

  Gustafsson, Britt ^a   Stål, Olle ^b   Gustafsson, Bertil ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Childhood acute lymphoblastic leukemia; Interaction; MDM 2; p53; Prognosis

Indexed keywords

ONCOPROTEIN; PROTEIN P53;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ONCOGENE; PROGNOSIS; PROTEIN STABILITY;

EID: 0031786826     PISSN: 08880018     EISSN: None     Source Type: Journal    
DOI: 10.3109/08880019809018313     Document Type: Article

References (20)

1. Holstein M, Sidransky D, Vogelstein B, Harris C. p53 mutations in human cancers. Science. 1991;253: 49-53.
2. Levine J, Momand J, Finlay CA. The p53 tumour suppressor gene. Nature. 1991;351-453.
3. Mashal R, Shtalrid M, Talpaz M, et al. Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia. Blood. 1990;75:180-189.
4. Lane DP. p53, guardian of the genome. Nature. 1992;358:15-16.
5. Sugimoto K, Toyoshima H, Sakai R, et al. Mutations of the p53 gene in lymphoid leukemia. Blood. 1991;77:1153-1156.
6. Gaidano G, Ballerini P, Gong JZ, et al. p53 mutations in human lymphoid malignancies: association with Burkitt's lymphoma and chrome lymphocytic leukemia. Proc Natl Acad Sci USA. 1991;88:5413-5417.
7. Sugimoto K., Hirano N, Toyoshima H, et al. Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia. Blood. 1993;81:3022.
8. Prococimer M, Rotter V. Structure and function of p-53 in normal cells and their aberrations in cancer cells: projection on the hematological cell lineages. Blood. 1994;84:2391-2411.
9. Felix CA, Nau MM, Takahashi T, et al. Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia. J Clin Invest. 1992;89:640-647.
10. Wada M, Bartram CR, Nakamura H, et al. Analysis of p53 mutations in a large series of lymphoid malignancies of childhood. Blood. 1993;82:3163-3169.
11. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53 associated protein in human sarcomas. Nature. 1992;358:80-83.
12. Meltzer PS. MDM2 and p53: a question of balance. J Natl Cancer Inst. 1994;84:1265-1266.
13. Ridge SA, Dyer M, Greaves MF, Wiedemann LM. Lack of MDM2 amplification in human leukaemia. Br J Haematol. 1994;86:407-409.
14. Bueso-Ramos CE, Yang Y, de Leon E, McCown P, Stass SA, Albitar M. The human MDM-2 oncogene is overexpressed in leukemias. Blood. 1993;82:2617-2623.
15. Quensel B, Preudhomm C, Oscier D, et al. Overexpression of the MDM2 gene is found in some cases of haematological malignancies. Br J Haematol. 1994;88.
16. Zhou M, Yeager AM, Smith SD, Findley HW. Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene. Blood. 1995;85:1608-1614.
17. Kaplan EL, Meier P. Nonparametic estimation from incomplete observations. J Am State Assoc. 1958;53: 457-481.
18. Zhang W, Hu G, Estey E, Hester J, Deisseroth A. Altered confirmation of the p53 protein in myeloid leukemia cells and mitogen-stimulated normal blood cells. Oncogene. 1992;7:1645-1647.
19. Gown AM, de Wever N, Battifora H. Microwave-based antigenic unmasking: a revolutionary new techniqxie for routine immunohistochemistry. Appl Immunol. 1993; 1:256-266.
20. Bueso-Ramos CE, Manshouri T, Haidar MA, Huh YO, Keating MJ, Albitar M. Multiple patterns of MDM-2 deregulation in human leukemias: implication in leukemogenesis and prognosis. Leuk Lymphoma. 1995;17:13-18.