Prevention of antigen-induced microtubule organizing center reorientation in cytotoxic T cells by modulation of protein kinase C activity

International Immunology

Volumn 10, Issue 11, 1998, Pages 1741-1746

  Nešić, Dragana ^a   Henderson, Scott ^b   Vukmanović, Stanislav ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cytotoxicity; Microtubule; Protein kinase C; T cells

Indexed keywords

ANTIGEN; GRANZYME A; MESSENGER RNA; PERFORIN; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CELL GRANULE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; ENZYME REGULATION; EXOCYTOSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; EXOCYTOSIS; FLUORESCENT ANTIBODY TECHNIQUE; LACTONES; MACROLIDES; MEMBRANE GLYCOPROTEINS; MICROTUBULES; PORE FORMING CYTOTOXIC PROTEINS; PROTEIN KINASE C; RNA, MESSENGER; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0031785762     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.11.1741     Document Type: Article

References (38)

1. 2+-independent T cell-mediated cytotoxicity. J. Exp. Med. 177:195.
2. Kagi, D., Vignaux, F., Ledermann, B., Burki, K., Depreatere, V., Nagata, S., Hengartner, H. and Goldstein, P. 1994. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265:528.
3. Lowin, B., Hahne, M., Mattmann, C. and Tschopp, J. 1994. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370:650.
4. Abbas, A. K, 1996. Die and let live: eliminating dangerous lymphocytes. Cell 84:655.
5. Kagi, D., Ledermann, B., Burki, K., Zinkernagel, R. M. and Hengartner, H. 1996. Molecular mechanisms of lymphocytemediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu. Rev. Immunol. 14:207.
6. Griffiths, G. M. 1995. The cell biology of CTL killing. Curr. Opin. Immunol. 7:343.
7. Berke, G. 1994. The binding and lysis of target cells by cytotoxic lymphocytes: molecular and cellular aspects. Annu. Rev. Immunol. 12:735.
8. Podack, E. R., Hengartner, H. and Lichtencheld, M. G. 1991. A central role of perforin in cytolysis? Annu. Rev. Immunol 9:129.
9. Shi, L., Kraut, R. P., Aebersold, R. and Greenberg, A. H. 1992. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J. Exp. Med. 175:553.
10. Takayama, H. and Sitkovsky, M. V. 1987. Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes. J. Exp. Med. 166:725.
11. Alberola-lla, J., S., T., Kerner, J. D. and Perlmutter, R. M. 1997. Differential signaling by lymphocyte antigen receptors. Annu. Rev. Immunol. 15:125.
12. Szamel, M. and Resch, K. 1995. T-cell antigen receptor-induced signal-transduction pathways. Activation and function of protein kinases C in T lymphocytes. Eur J. Biochem. 228:1.
13. Gomez, J., Pitton, C., Garcia, A., Martinez de Aragon, A., Silva, A. and Rebollo, A. 1995. The ζ isoform of protein kinase C controls interleukin-2-mediated proliferation in a murine T cell line: evidence for an additional role of protein kinase C ε and β. Exp. Cell Res. 218:105.
14. Stewart, M. P., Cabanas, C. and Hogg, N. 1996. T cell adhesion to intracellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1. J Immunology. 156:1810.
15. Entschladen, F., Niggemmann, B., Zanker, K. S. and Friedl, P. 1997. Differential requirement of protein tyrosine kinases and protein kinase C in the regulation of T cell locomotion in three-dimensional collagen matrices. J. Immunol. 159:3202.
16. + cytotoxic T lymphocyte clones. Eur. J. Immunol. 25:3381.
17. Ruiz-Ruiz, M. C., Izquierdo, M., de Murcia, G. and Lopez-Rivas, A. 1997. Activation of protein kinase C attenuates early signals in Fas-mediated apoptosis. Eur J. Immunol. 27:1769.
18. Backstrom, B. T., Rubin, B., Peter, A., Tiefethaler, G. and Palmer, E. 1997. T cell receptor alpha-chain tail is required for protein kinase C-mediated down-regulation, but not for signaling. Eur. J. Immunol. 27:1433.
19. Genot, E. M., Parker, P. and Cantrell, D. A. 1995. Analysis of the role of protein kinase C-α, -ε and -ζ in T cell activation. J. Biol. Chem. 270:9833.
20. + T lymphocyte effector responses. J. Immunol. 159:582.
21. 2+-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. J. Biol. Chem. 268:1749.
22. Lichtenheld, M. G., Podack, E. R. and Levy, R. B. 1995. Transgenic control of perforin gene expression. J. Immunol. 154:2153.
23. + T cells from β2-microglobulin-deficient (β2m-/-) mice to syngeneic β2m+/+ cells. J. Immunol. 154:6252.
24. Geiger, B., Rosen, D. and Berke, G. 1982. Spacial relationships of microtubule-organizing centers and contact area of cytotoxic T lymphocytes and target cells. J. Cell Biol. 95:137.
25. Wilkinson, S. E., Parker, P. J. and Nixon, J. S. 1993. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem. J. 294:335.
26. Isakov, N., Galron, D., Mustelin, T., Pettit, G, R. and Altman, A. 1993. Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C. J Immunol. 150:1195.
27. Isaaz, S., Baetz, K., Olsen, K., Podack, E. and Griffiths, G. M. 1995. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway. Eur. J. Immunol. 25:1071.
28. Hahn, K, DeBiasio, R., Tishon, A., Lewicki, H., Gairin, J. E., LaRocca, G., Taylor, D. L. and Oldstone, M. 1994. Antigen presentation and cytotoxic T lymphocyte killing studied in individual, living cells. Virology 201:330.
29. Zagury, D., Bernard, J., Thierness, N., Feldman, M. and Berke, G. 1975. Isolation and characterization of individual functionally reactive cytotoxic T lymphocytes: conjugation, killing and recycling at the single cell level. Eur J. Immunol. 5:818
30. Kupfer, A., Dennert, G. and Singer, S. J. 1983. Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets. Proc. Natl Acad. Sci. USA 80:7224.
31. Ainsztein, A. M. and Purich, D. L. 1994, Stimulation of tubulin polymerization by MAP-2. J. Biol. Chem. 269:28465.
32. Robinson, P. J., Sontag, J.-M., Liu, J.-P., Fykse, E. M., Slaughter, C., McMahon, H. and Sudhof, T. C. 1993. Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals. Nature 365:163.
33. Mcllvain, J. M., Burkhardt, J. K., Hamm-Alvarez, S., Argon, Y. and Sheetz, M. P. 1994. Regulation of kinesin activity by phosphorylation of kinesin-associated proteins. J. Biol. Chem. 269:19176.
34. Burkhardt, J. K., Mcllvain, J. M. J., Sheetz, M. P. and Argon, Y. 1993. Lytic granules from cytotoxic T cells exhibit kinesin-dependent motility on microtubules in vitro. J. Cell Sci. 104:151.
35. Barbosa, M. D. F. S., Nguyen, Q. A., Tchernev, V. T., Ashley, J. A., Detter, J. C., Blaydes, S. M., Brandt, S. J., Chotai, D., Hodgman, C., Solari, R. C. E., Lovett, M. and Kingsmore, S. F. 1996. Identification of the homologous beige and Chediak-Higashi syndrome genes. Nature 382:262.
36. Ito, M., Sato, A., Tanabe, F., Ishida, E., Takami, Y. and Shigeta, S. 1989. The thiol protease inhibitors improve the abnormal rapid down-regulation of protein kinase C and the impaired natural killer cell activity in (Chediak-Higashi syndrome) beige mouse. Biochem. Biophys. Res. Commun 160:433.
37. Ratner, S., Sherrod, W. S. and Lichlyter, D. 1997. Microtubule retraction into the uropod and its role in T cell polarization and motility. J. Immunol. 159:1063.
38. Kupfer, H., Monks, C. R. F. and Kupfer, A. 1994. Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions. J. Exp. Med. 179:1507.