In vivo formation of codeinone-glutathione adduct: Isolation and identification of a new metabolite in the bile of codeine-treated guinea pig

Journal of Analytical Toxicology

Volumn 22, Issue 7, 1998, Pages 567-572

  Ishida, Takashi ^a   Yano, Masashi ^a   Toki, Satoshi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; CODEINONE; GLUTATHIONE; MORPHINE; UNCLASSIFIED DRUG; [4,5 EPOXY 3 METHOXY 17 METHYL 6 OXOMORPHINANYL]GLUTATHIONE;

ANIMAL CELL; ARTICLE; DRUG ABUSE; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG METABOLISM; DRUG PURIFICATION; DRUG SCREENING; FOURIER TRANSFORMATION; GUINEA PIG; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0031785543     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/22.7.567     Document Type: Article

References (4)

1. J. Axelrod. The enzymic N-demethylation of narcotic drugs. J. Pharmacol. Exp. Ther. 117: 322-330 (1955).
2. T.K. Adler, J.M. Fujimoto, E.L. Way, and E.M. Baker. Metabolic fate of codeine in man. J. Pharmacol. Exp. Ther. 114: 251-262 (1955).
3. L.A. Wood, H.E. Mehlenbeck, and L.B. Mellett. Plasma level and excretion of codeine and metabolites in the dog and monkey. J. Pharmacol. Exp. Ther. 117: 117-125 (1956).
4. T.K. Adler. Morphine tolerance in mice I. In vivo N-demethylation of morphine and N- and O-demethylation of codeine. J. Pharmacol. Exp. Ther. 156: 585-590 (1967).