메뉴 건너뛰기




Volumn 22, Issue 10, 1998, Pages 1005-1010

IFN-γ-mediated prevention of graft-versus-host disease: Pharmacodynamic studies and influence on proliferative capacity of chimeric spleen cells

Author keywords

BMT; GVHD; IFN

Indexed keywords

CONCANAVALIN A; CYTOKINE; GAMMA INTERFERON;

EID: 0031784864     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1701478     Document Type: Article
Times cited : (22)

References (54)
  • 1
    • 0002091226 scopus 로고
    • Graft-versus-Host Disease
    • Van Bekkum DW, Löwenberg B (eds). Marcel Dekker: New York
    • Van Bekkum DW. Graft-versus-Host Disease. In: Van Bekkum DW, Löwenberg B (eds). Bone Marrow Transplantation. Marcel Dekker: New York, 1985, pp 147-212.
    • (1985) Bone Marrow Transplantation , pp. 147-212
    • Van Bekkum, D.W.1
  • 2
    • 0028111081 scopus 로고
    • Graft-versus-host disease: New directions for a persistent problem
    • Vogelsang VB, Hess AD. Graft-versus-host disease: new directions for a persistent problem. Blood 1994; 84: 2061- 2067.
    • (1994) Blood , vol.84 , pp. 2061-2067
    • Vogelsang, V.B.1    Hess, A.D.2
  • 3
    • 0023636166 scopus 로고
    • Risk factors for acute graft-versus-host disease
    • Gale RP, Bortin MM, Van Bekkum DW et al. Risk factors for acute graft-versus-host disease. Br J Haematol 1987; 67: 397-406.
    • (1987) Br J Haematol , vol.67 , pp. 397-406
    • Gale, R.P.1    Bortin, M.M.2    Van Bekkum, D.W.3
  • 4
    • 0023073577 scopus 로고
    • Histoincompatible bone marrow transplants in humans
    • Clift RA, Storb R. Histoincompatible bone marrow transplants in humans. Annu Rev Immunol 1987; 5: 43-64.
    • (1987) Annu Rev Immunol , vol.5 , pp. 43-64
    • Clift, R.A.1    Storb, R.2
  • 5
    • 0024537269 scopus 로고
    • Effect of HLA compatibility on engraftment of bone marrow transplantation in patients with leukemia or lymphoma
    • Anasetti C, Amos D, Beatty PG et al. Effect of HLA compatibility on engraftment of bone marrow transplantation in patients with leukemia or lymphoma. New Engl J Med 1989; 320: 197-204.
    • (1989) New Engl J Med , vol.320 , pp. 197-204
    • Anasetti, C.1    Amos, D.2    Beatty, P.G.3
  • 6
    • 0023891957 scopus 로고
    • Cytokines as mediators of graft-versus-host disease
    • Cohen J. Cytokines as mediators of graft-versus-host disease. Bone Marrow Transplant 1988; 3: 193-197.
    • (1988) Bone Marrow Transplant , vol.3 , pp. 193-197
    • Cohen, J.1
  • 7
    • 0026660658 scopus 로고
    • The role of cytokines in graft-versus-host reactions and disease
    • Jadus MR, Wepsic HT. The role of cytokines in graft-versus- host reactions and disease. Bone Marrow Transplant 1992; 10: 1-14.
    • (1992) Bone Marrow Transplant , vol.10 , pp. 1-14
    • Jadus, M.R.1    Wepsic, H.T.2
  • 8
    • 0027451923 scopus 로고
    • Cytokine dysregulation as a mechanism of graft-versus-host disease
    • Ferrera JM. Cytokine dysregulation as a mechanism of graft- versus-host disease. Curr Opin Immunol 1993; 5: 794-799.
    • (1993) Curr Opin Immunol , vol.5 , pp. 794-799
    • Ferrera, J.M.1
  • 9
    • 0027048743 scopus 로고
    • Cytokine dysregulation and acute graft-versus-host disease
    • Antin JH, Ferrara JLM. Cytokine dysregulation and acute graft-versus-host disease. Blood 1992; 12: 2964-2968.
    • (1992) Blood , vol.12 , pp. 2964-2968
    • Antin, J.H.1    Ferrara, J.L.M.2
  • 10
    • 0026573134 scopus 로고
    • Macrophage priming and lipopolysaccharide triggered release of tumor necrosis factor α during graft-versus-host disease
    • Nestel FP, Price KS, Seemayer TA, Lapp WS. Macrophage priming and lipopolysaccharide triggered release of tumor necrosis factor α during graft-versus-host disease. J Exp Med 1992; 175: 405-413.
    • (1992) J Exp Med , vol.175 , pp. 405-413
    • Nestel, F.P.1    Price, K.S.2    Seemayer, T.A.3    Lapp, W.S.4
  • 11
    • 0025011924 scopus 로고
    • Endogenous IFN-gamma during human bone marrow transplantation
    • Niederwieser D, Herold M, Woloszczuk W et al. Endogenous IFN-gamma during human bone marrow transplantation. Transplantation 1992; 50: 620-625.
    • (1992) Transplantation , vol.50 , pp. 620-625
    • Niederwieser, D.1    Herold, M.2    Woloszczuk, W.3
  • 12
    • 0024342108 scopus 로고
    • Antibodies to IFN-γ prevent immunological mediated intestinal damage in murine graft-versus-host reaction
    • Mowat AMcI. Antibodies to IFN-γ prevent immunological mediated intestinal damage in murine graft-versus-host reaction. Immunology 1989; 68: 18-23.
    • (1989) Immunology , vol.68 , pp. 18-23
    • Mowat, A.1
  • 13
    • 0025890101 scopus 로고
    • Prophylaxis of graft- Verus-host disease by administration of the murine anti-IL-2 receptor antibody 2A3
    • Anasetti C, Martin PJ, Storb R et al. Prophylaxis of graft- verus-host disease by administration of the murine anti-IL-2 receptor antibody 2A3. Bone Marrow Transplant 1991; 7: 375-381.
    • (1991) Bone Marrow Transplant , vol.7 , pp. 375-381
    • Anasetti, C.1    Martin, P.J.2    Storb, R.3
  • 14
    • 0029865505 scopus 로고    scopus 로고
    • Close simulation of acute graft-versus-host disease by interleukin-2 administered after autologous bone marrow transplantation for hematologic malignancy
    • Massumoto C, Benyunes MC, Sale G et al. Close simulation of acute graft-versus-host disease by interleukin-2 administered after autologous bone marrow transplantation for hematologic malignancy. Bone Marrow Transplant 1996; 17: 351-356.
    • (1996) Bone Marrow Transplant , vol.17 , pp. 351-356
    • Massumoto, C.1    Benyunes, M.C.2    Sale, G.3
  • 15
    • 0027971672 scopus 로고
    • IL-12 stimulates the development of acute graft-versus-host disease in mice that would normally develop chronic, autoimmune graft-versus- Host disease
    • Via C, Rus V, Gately MK, Finkelman FD. IL-12 stimulates the development of acute graft-versus-host disease in mice that would normally develop chronic, autoimmune graft-versus- host disease. J Immunol 1994; 153: 4040-4047.
    • (1994) J Immunol , vol.153 , pp. 4040-4047
    • Via, C.1    Rus, V.2    Gately, M.K.3    Finkelman, F.D.4
  • 16
    • 0030006734 scopus 로고    scopus 로고
    • IL-12 is a central mediator of acute graft-versus-host disease in mice
    • Williamson E, Garside P, Bradley JA, Mowat AMcI. IL-12 is a central mediator of acute graft-versus-host disease in mice. J Immunol 1996; 156: 689-699.
    • (1996) J Immunol , vol.156 , pp. 689-699
    • Williamson, E.1    Garside, P.2    Bradley, J.A.3    Mowat, A.4
  • 17
    • 0025986570 scopus 로고
    • Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease
    • McCarthy PL, Abhyankar S, Neben S et al. Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease. Blood 1991; 78: 1915-1918.
    • (1991) Blood , vol.78 , pp. 1915-1918
    • McCarthy, P.L.1    Abhyankar, S.2    Neben, S.3
  • 18
    • 0025008619 scopus 로고
    • Increased serum levels of tumor necrosis factor a precede major complications of bone marrow transplantation
    • Holler E, Kolb HJ, Möller A et al. Increased serum levels of tumor necrosis factor a precede major complications of bone marrow transplantation. Blood 1990; 75: 1011-1016.
    • (1990) Blood , vol.75 , pp. 1011-1016
    • Holler, E.1    Kolb, H.J.2    Möller, A.3
  • 19
    • 0023620524 scopus 로고
    • Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease
    • Piguet P-F, Grau GE, Allet B, Vassalli P. Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease. J Exp Med 1987; 166: 1280-1289.
    • (1987) J Exp Med , vol.166 , pp. 1280-1289
    • Piguet, P.-F.1    Grau, G.E.2    Allet, B.3    Vassalli, P.4
  • 20
    • 0027333549 scopus 로고
    • Interferon-γ prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice
    • Brok HPM, Heidt PJ, Van der Meide PH et al. Interferon-γ prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice. J Immunol 1993; 151: 6451- 6459.
    • (1993) J Immunol , vol.151 , pp. 6451-6459
    • Brok, H.P.M.1    Heidt, P.J.2    Van der Meide, P.H.3
  • 21
    • 0025268937 scopus 로고
    • In vivo administration of interleukin 2 plus T-cell depleted syngeneic marrow prevents graft-versus-host disease and permits alloengraftment
    • Sykes M, Rommick ML, Hoyles KA, Sachs DH. In vivo administration of interleukin 2 plus T-cell depleted syngeneic marrow prevents graft-versus-host disease and permits alloengraftment. J Exp Med 1990; 171: 645-658.
    • (1990) J Exp Med , vol.171 , pp. 645-658
    • Sykes, M.1    Rommick, M.L.2    Hoyles, K.A.3    Sachs, D.H.4
  • 22
    • 0026642629 scopus 로고
    • The mechanism of IL-2-mediated pretection against GVHD in mice. II Protection occurs independently of NK/LAK cells
    • Sykes M, Abraham VS. The mechanism of IL-2-mediated pretection against GVHD in mice. II Protection occurs independently of NK/LAK cells, Transplantation 1992; 53: 1063- 1070.
    • (1992) Transplantation , vol.53 , pp. 1063-1070
    • Sykes, M.1    Abraham, V.S.2
  • 24
    • 0026682860 scopus 로고
    • Mechanism of protection from graft-versus-host disease mortality by IL-2. III. Early reduction in donor T cell subsets and expansion of a CD3+CD4-CD8- Cell population
    • Abraham VS, Sachs DH, Sykes M. Mechanism of protection from graft-versus-host disease mortality by IL-2. III. Early reduction in donor T cell subsets and expansion of a CD3+CD4-CD8- cell population. J Immunol 1992; 148: 3746-3752.
    • (1992) J Immunol , vol.148 , pp. 3746-3752
    • Abraham, V.S.1    Sachs, D.H.2    Sykes, M.3
  • 25
    • 0028560025 scopus 로고
    • IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host disease
    • Szebeni J, Wang MG, Pearson DA et al. IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host disease. Transplantation 1994; 58: 1385- 1393.
    • (1994) Transplantation , vol.58 , pp. 1385-1393
    • Szebeni, J.1    Wang, M.G.2    Pearson, D.A.3
  • 26
    • 0029114990 scopus 로고
    • Interleukin-12 inhibits murine graft-versus-host disease
    • Sykes M, Szot GL, Nguyen PL, Pearson DA. Interleukin-12 inhibits murine graft-versus-host disease. Blood 1995; 86: 2429-2438.
    • (1995) Blood , vol.86 , pp. 2429-2438
    • Sykes, M.1    Szot, G.L.2    Nguyen, P.L.3    Pearson, D.A.4
  • 27
    • 0030969766 scopus 로고    scopus 로고
    • Interferon-γ mediated prevention of graft-versus-host disease: Development of immune competent and allo-tolerant T cells in chimeric mice
    • Brok HPM, Vossen JM, Heidt PJ. Interferon-γ mediated prevention of graft-versus-host disease: development of immune competent and allo-tolerant T cells in chimeric mice. Bone Marrow Transplant 1997; 19: 601-606.
    • (1997) Bone Marrow Transplant , vol.19 , pp. 601-606
    • Brok, H.P.M.1    Vossen, J.M.2    Heidt, P.J.3
  • 28
    • 0026448233 scopus 로고
    • Experimental and clinical gnotobiotics: Influence of the microflora on graft-versus-host disease after allogeneic bone marrow transplantation
    • Heidt PJ, Vossen JM. Experimental and clinical gnotobiotics: influence of the microflora on graft-versus-host disease after allogeneic bone marrow transplantation. J Med 1992; 23: 161-173.
    • (1992) J Med , vol.23 , pp. 161-173
    • Heidt, P.J.1    Vossen, J.M.2
  • 29
    • 0015987803 scopus 로고
    • Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora
    • Van Bekkum DW, Roodenburg J, Heidt PJ, Van der Waaij D. Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora. J Natl Cancer Inst 1974; 52: 401-404.
    • (1974) J Natl Cancer Inst , vol.52 , pp. 401-404
    • Van Bekkum, D.W.1    Roodenburg, J.2    Heidt, P.J.3    Van der Waaij, D.4
  • 31
    • 1842295304 scopus 로고
    • Identification of CFU-s by scatter measurements on a light activated cell sorter
    • Baum SJ, Ledney GD (eds). Springer Verlag: New York
    • Van den Engh G, Visser J, Trask B. Identification of CFU-s by scatter measurements on a light activated cell sorter. In: Baum SJ, Ledney GD (eds). Experimental Hematology Today. Springer Verlag: New York, 1978, pp 19-26.
    • (1978) Experimental Hematology Today , pp. 19-26
    • Van den Engh, G.1    Visser, J.2    Trask, B.3
  • 32
    • 0025190653 scopus 로고
    • The potential of interferons in malignant disease
    • Okita K, Kaneko T. The potential of interferons in malignant disease. Drugs 1990; 39: 1-6.
    • (1990) Drugs , vol.39 , pp. 1-6
    • Okita, K.1    Kaneko, T.2
  • 33
    • 0022600846 scopus 로고
    • Phase I trial of recombinant interferon gamma in cancer patients
    • Vadjan-Raj S, Al-Katib A, Bhalla R et al. Phase I trial of recombinant interferon gamma in cancer patients. J Clin Oncol 1986; 4: 137-146.
    • (1986) J Clin Oncol , vol.4 , pp. 137-146
    • Vadjan-Raj, S.1    Al-Katib, A.2    Bhalla, R.3
  • 34
    • 0026563941 scopus 로고
    • Phase I study of recombinant human interferon gamma in children with relapsed acute leukemia
    • Mahmoud HH, Pui C-H, Kennedy W et al. Phase I study of recombinant human interferon gamma in children with relapsed acute leukemia. Leukemia 1992; 6: 1181-1184.
    • (1992) Leukemia , vol.6 , pp. 1181-1184
    • Mahmoud, H.H.1    Pui, C.-H.2    Kennedy, W.3
  • 35
    • 0022472884 scopus 로고
    • The purification and characterization of rat gamma-interferon by use of two monoclonal antibodies
    • Van der Meide PH, Dubbeld M, Vijverberg K et al. The purification and characterization of rat gamma-interferon by use of two monoclonal antibodies. J Gen Virol 1986; 67: 1059-1071.
    • (1986) J Gen Virol , vol.67 , pp. 1059-1071
    • Van der Meide, P.H.1    Dubbeld, M.2    Vijverberg, K.3
  • 36
    • 0028972008 scopus 로고
    • Augmentation or inhibition of IFN-γ-induced MHC class II expression by lipopolysaccharides. the roles of TNF-α and nitric oxide, and the importance of the sequence of signalling
    • Sicher SC, Chung GW, Vazquez MA, Lu CY. Augmentation or inhibition of IFN-γ-induced MHC class II expression by lipopolysaccharides. The roles of TNF-α and nitric oxide, and the importance of the sequence of signalling. J Immunol 1995; 155: 5826-5834.
    • (1995) J Immunol , vol.155 , pp. 5826-5834
    • Sicher, S.C.1    Chung, G.W.2    Vazquez, M.A.3    Lu, C.Y.4
  • 37
    • 0026568118 scopus 로고
    • Cytokine production after intravenous or peritoneal gram-negative bacterial challenge in mice. Comperative protective efficacy of antibodies to tumor necrosis factor α and to lipopolysaccharide
    • Zanetti G, Heumann D, Gerain J Kohler J et al. Cytokine production after intravenous or peritoneal gram-negative bacterial challenge in mice. Comperative protective efficacy of antibodies to tumor necrosis factor α and to lipopolysaccharide. J Immunol 1992; 148: 1890-1897.
    • (1992) J Immunol , vol.148 , pp. 1890-1897
    • Zanetti, G.1    Heumann, D.2    Gerain, J.3    Kohler, J.4
  • 38
    • 45549117696 scopus 로고
    • Gamma-interferon: The match that lights the fire?
    • Billiau A. Gamma-interferon: the match that lights the fire? Immunol Today 1988; 9: 37-40.
    • (1988) Immunol Today , vol.9 , pp. 37-40
    • Billiau, A.1
  • 39
    • 0026786992 scopus 로고
    • Murine hypersensitivity pneumonitis- Bidirectional role of interferon-gamma
    • Denis M, Ghadirian E. Murine hypersensitivity pneumonitis- Bidirectional role of interferon-gamma. Clin Exp Allergy 1992; 22: 783-792.
    • (1992) Clin Exp Allergy , vol.22 , pp. 783-792
    • Denis, M.1    Ghadirian, E.2
  • 40
    • 0026754027 scopus 로고
    • Phase I-II trail of a monoclonal anti-tumor necrosis factor α antibody for the treatment of refractory severe acute graft-versusthost disease
    • Herve P, Flesch M, Tiberghien P et al. Phase I-II trail of a monoclonal anti-tumor necrosis factor α antibody for the treatment of refractory severe acute graft-versusthost disease. Blood 1992; 79; 3362-3368.
    • (1992) Blood , vol.79 , pp. 3362-3368
    • Herve, P.1    Flesch, M.2    Tiberghien, P.3
  • 41
    • 0029620231 scopus 로고
    • Interleukin-1 or tumor necrosis factor-α antagonists do not inhibit graft-versus-host disease induced across the major histocompatability barrier in mice
    • Vallera DA, Taylor PA, Vannice JL et al. Interleukin-1 or tumor necrosis factor-α antagonists do not inhibit graft-versus- host disease induced across the major histocompatability barrier in mice. Transplantation 1995; 60: 1371-1374.
    • (1995) Transplantation , vol.60 , pp. 1371-1374
    • Vallera, D.A.1    Taylor, P.A.2    Vannice, J.L.3
  • 42
    • 0028270040 scopus 로고
    • IL-12 influences intrathytnic T cell development
    • Godfrey, DI, Gately MK, Hakimi J et al. IL-12 influences intrathytnic T cell development. J Immunol 1994; 152: 2729-2735.
    • (1994) J Immunol , vol.152 , pp. 2729-2735
    • Godfrey, D.I.1    Gately, M.K.2    Hakimi, J.3
  • 43
    • 0028968497 scopus 로고
    • Administration of recombinant interleukin-12 to mice suppresses hematopoiesis in the bone marrow but enhances hematopoiesis in the spleen
    • Tare NS, Bowen S. Warrier RR et al. Administration of recombinant interleukin-12 to mice suppresses hematopoiesis in the bone marrow but enhances hematopoiesis in the spleen. J Interferon Cytokine Res 1995; 15: 377-383.
    • (1995) J Interferon Cytokine Res , vol.15 , pp. 377-383
    • Tare, N.S.1    Bowen, S.2    Warrier, R.R.3
  • 44
    • 0029742960 scopus 로고    scopus 로고
    • Interferon-γ surpresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease
    • Krenger W, Falzarano G, Delmonte J et al. Interferon-γ surpresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease. Blood 1996; 88: 1113-1121.
    • (1996) Blood , vol.88 , pp. 1113-1121
    • Krenger, W.1    Falzarano, G.2    Delmonte, J.3
  • 45
    • 0024346258 scopus 로고
    • Murine natural suppressor cells in the newborn, in bone marrow, and after cyclophosphamide. Genetic variation and dependence on IFN-γ
    • Maier T, Holda JH, Claman HN. Murine natural suppressor cells in the newborn, in bone marrow, and after cyclophosphamide. Genetic variation and dependence on IFN-γ. J Immunol 1989; 143: 491-498.
    • (1989) J Immunol , vol.143 , pp. 491-498
    • Maier, T.1    Holda, J.H.2    Claman, H.N.3
  • 47
    • 0024361199 scopus 로고
    • - surface phenotype and the alpha, beta heterodimer of the T cell antigen receptor
    • - surface phenotype and the alpha, beta heterodimer of the T cell antigen receptor. J Immunol 1989; 143: 1118-1122.
    • (1989) J Immunol , vol.143 , pp. 1118-1122
    • Strober, S.1    Dejbachsh-Jones, S.2    Van Vlassalaer, P.3
  • 48
    • 0020001644 scopus 로고
    • Modulation of F1 cytotoxic potential by GVHR: Suppression of cytotoxic T cell responses in F1 mice correlates with F1 inability to resist the proliferation of GVHR-inducing parental T lymphocytes
    • Ishikawa H, Kubota E, Wilkinson NM, Saiko K. Modulation of F1 cytotoxic potential by GVHR: suppression of cytotoxic T cell responses in F1 mice correlates with F1 inability to resist the proliferation of GVHR-inducing parental T lymphocytes. J Immunol 1982; 129: 1181-1188.
    • (1982) J Immunol , vol.129 , pp. 1181-1188
    • Ishikawa, H.1    Kubota, E.2    Wilkinson, N.M.3    Saiko, K.4
  • 49
    • 0027092060 scopus 로고
    • T- Cell subsets and suppressor cells in human bone marrow
    • Schmidt-Wolf IGH, Dejbakhsh-Jones S, Ginzton N et al. T- cell subsets and suppressor cells in human bone marrow. Blood 1992; 12: 3242-3250.
    • (1992) Blood , vol.12 , pp. 3242-3250
    • Igh, S.-W.1    Dejbakhsh-Jones, S.2    Ginzton, N.3
  • 50
    • 0023114644 scopus 로고
    • Cloned natural suppressor cells prevent lethal graft-vs-host disease
    • Strober S, Palathumpat V, Schwadron R, Hertel-Wulff B. Cloned natural suppressor cells prevent lethal graft-vs-host disease. J Immunol 1987; 138: 699-703.
    • (1987) J Immunol , vol.138 , pp. 699-703
    • Strober, S.1    Palathumpat, V.2    Schwadron, R.3    Hertel-Wulff, B.4
  • 51
    • 0026641751 scopus 로고
    • Intensive immunotherapy with recombinant IL2 after autologous bone marrow transplantation is associated with a high incidence of bacterial infections
    • Blaise D, Stoppa AM, Viens P et al. Intensive immunotherapy with recombinant IL2 after autologous bone marrow transplantation is associated with a high incidence of bacterial infections. Bone Marrow Transplant 1992; 10: 193-195.
    • (1992) Bone Marrow Transplant , vol.10 , pp. 193-195
    • Blaise, D.1    Stoppa, A.M.2    Viens, P.3
  • 52
    • 0026555994 scopus 로고
    • IL-2 infusion abbrogates humoral immune responses in humans
    • Gottlieb DJ, Prentice HG, Heslop HE et al. IL-2 infusion abbrogates humoral immune responses in humans. Clin Exp Immunol 1992; 87: 493-498.
    • (1992) Clin Exp Immunol , vol.87 , pp. 493-498
    • Gottlieb, D.J.1    Prentice, H.G.2    Heslop, H.E.3
  • 53
    • 0030019977 scopus 로고    scopus 로고
    • Phase I trial of interleukin-2 after unmodified HLA-matched sibling bone marrow transplantation for children with acute leukemia
    • Robinson N, Sanders JE, Benyunes MC et al. Phase I trial of interleukin-2 after unmodified HLA-matched sibling bone marrow transplantation for children with acute leukemia. Blood 1996; 87: 1249-1254.
    • (1996) Blood , vol.87 , pp. 1249-1254
    • Robinson, N.1    Sanders, J.E.2    Benyunes, M.C.3
  • 54
    • 0028179006 scopus 로고
    • Lymphocyte responses and cytokines (review)
    • Paul WE, Seder RA. Lymphocyte responses and cytokines (review). Cell 1994; 76: 241-251.
    • (1994) Cell , vol.76 , pp. 241-251
    • Paul, W.E.1    Seder, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.