Permeability of articular cartilage to matrix metalloprotease inhibitors

Pharmaceutical Research

Volumn 15, Issue 9, 1998, Pages 1414-1418

  Peng, Sean X ^a   VonBargen, Edward C ^a   Bornes, David M ^a   Pikul, Stanislaw ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Cartilage location; Cartilage permeability; HPLC; Hydrophilicity; Matrix metalloprotease inhibitors

Indexed keywords

ENZYME INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; METALLOPROTEINASE INHIBITOR; N HYDROXY 1,3 DI [4 METHOXYBENZENESULPHONYL] 5 HYDROXY [1,3]CYCLOHEXYLDIAZINE 2 CARBOXAMIDE; N HYDROXY 1,3 DI [4 METHOXYBENZENESULPHONYL] 5,5 DIMETHYL [1,3]CYCLOHEXYLDIAZINE 2 CARBOXAMIDE; N HYDROXY 1,3 DI [4 METHOXYBENZENESULPHONYL] [1,3]CYCLOHEXYLDIAZINE 2 CARBOXAMIDE; N HYDROXY 1,3 DI [4 METHOXYBENZENESULPHONYL] [1,3]CYCLOPENTYLDIAZINE 2 CARBOXAMIDE; PGE 113288; PGE 4410186; PGE 9445565; PGE 9818266; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CATTLE; DRUG PENETRATION; DRUG STRUCTURE; DRUG TISSUE LEVEL; FREEZING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; THAWING; TISSUE DISTRIBUTION;

ANIMALS; BIOLOGICAL TRANSPORT; CARTILAGE, ARTICULAR; CATTLE; ENZYME INHIBITORS; JOINTS; METALLOENDOPEPTIDASES; MODELS, BIOLOGICAL; PERMEABILITY; WATER;

EID: 0031784785     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011905806123     Document Type: Article

References (10)

1. R. V. Allhands, P. A. Torzilli, and F. A. Kallfelz. Measurement of diffusion of uncharged molecules in articular cartilage. Cornell Vet. 74:111-123 (1984).
2. A. Maroudas. Transport of solutes through cartilage: Permeability to large molecules. J. Anat. 122:335-347 (1976).
3. P. A. Torzilli. Effects of temperature, concentration and articular surface removal on transient solute diffusion in articular cartilage Med. Biol. Eng. & Comput. 31:S93-S98 (1993).
4. W. Y. Gu, W. M. Lai, and V. C. Mow. Transport of fluid and ions through a porous-permeable charged-hydrated tissue, and streaming potential data on normal bovine articular cartilage. J. Biomechanics. 26:709-723 (1993).
5. W. B. Van den Berg, P. L. E. M. Van Lent, L. B. A. Van de Putte, and W. A. Zwarts. Electrical charge of hyaline articular cartilage: Its role in the retention of anionic and cationic proteins. Clin. Immunol. Immunopathol. 39:187-197 (1986).
6. A. Martin. Physical Pharmacy. Ch. 13, 4th ed., Lea & Febiger, Philadelphia, 1993.
7. M. D. Ribadeneira, B. J. Aungst, C. J. Eyermann, and S.-M. Huang. Effects of structural modifications on the intestinal permeability of angiotensin II receptor antagonists and the correlation of in vitro, in situ, and in vitro absorption. Pharm. Res. 13:227-233 (1996).
8. C. K. Lee, T. Uchida, K. Kitagawa, A. Yagi, N.-S. Kim, and S. Goto. Skin permeability of various drugs with different lipophilicity. J. Pharm. Sci. 83:562-565 (1994).
9. A. R. Poole. Cartilage in Health and Disease. In D. J. McCarty and W. J. Koopman (eds.), Arthritis and Allied Conditions, 12th ed., Lea & Febiger, Philadelphia, 1993, pp. 279-333.
10. E. Handler-Bernich, P. Lotke, and R. Rubenstein. Membrane characteristics of human articular cartilage. Biochim. Biophys. Acta. 266:732-736 (1972).