Development of a method for the quantitation of benzphetamine metabolites in human urine by high-performance liquid chromatography

Annals of Clinical Biochemistry

Volumn 35, Issue 6, 1998, Pages 775-779

  Fujinami, Aya ^a   Miyazawa, Tadashi ^b   Kobayashi, Yoshiharu ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b Chuo ward   (Japan)

Author keywords

p hydroxy benzphetamine; p hydroxy N benzylamphetamine

Indexed keywords

2 PROPANOL; ACETIC ACID; ACETONITRILE; AMPHETAMINE DERIVATIVE; BENZPHETAMINE; BENZYL DERIVATIVE; BETA GLUCURONIDASE; DICHLOROMETHANE; DRUG METABOLITE; GLUCURONIDE; HYDROXYL GROUP; METHANOL;

ARTICLE; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; METABOLITE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TEMPERATURE;

EID: 0031784729     PISSN: 00045632     EISSN: None     Source Type: Journal    
DOI: 10.1177/000456329803500611     Document Type: Article

References (12)

1. Chait LD, Uhlenhuth EH, Johanson CE. Reinforcing and subjective effects of several anorectics in normal human volunteers. J Pharmacol Exp Ther 1987; 242: 777-83
2. Inoue T, Suzuki S. The metabolism of 1-phenyl-2-(N-methyl-N-benzylamino)propane (Benzphetamine) and 1-phenyl-2-(N-methyl-N-furfurylamino)propane (Furfenorex) in man. Xenobiotica 1986; 16: 691-8
3. Niwaguchi T, Inoue T, Suzuki S. The metabolism of 1-phenyl-2-(N-methyl-N-benzylamino)propane (Benzphetamine) in vivo in the rat. Xenobiotica 1982; 12: 617-25
4. Kikura R, Nakahara Y. Hair analysis for drugs of abuse. II. Disposition of benzphetamine and its metabolites into hair and comparison of benzphetamine use and methamphetamine use by hair analysis. Biol Pharm Bull 1995; 18: 1694-9
5. Shimosato K, Tomita M, Ijiri I. Urinary excretion of p-hydroxylated methamphetamine metabolites in man. I. A method for determination by high-performance liquid chromatography-electrochemistry. Arch Toxicol 1986; 59: 135-40
6. Ferrara D, Tedeschi L, Frison G, Castagna F. Solid-phase extraction and confirmation of drugs of abuse in urine. J Anal Toxicol 1992; 16: 217-22
7. Tedeschi L, Frison G, Castagna F, Giorgetti R, Ferrara D. Simultaneous identification of amphetamine and its derivatives in urine using HPLC-UV. Int J Legal Med 1993; 105: 265-9
8. Hayakawa K, Miyoshi Y, Kurimoto H, Matsusima Y, Takayama N, Tanaka S, et al. Simultaneous determination of methamphetamine and its metabolites in the urine samples of abusers by high performance liquid chromatography with chemiluminescence detection. Biol Pharm Bull 1993; 16: 817-21
9. Fujinami A, Miyazawa T, Kobayashi Y, Watanabe F. Development of a method for the measurement of benzphetamine metabolites in urine using HPLC after solid phase extraction. Jpn J Clin Chem 1996; 25: 243-52
10. Heizelman V, Aspergrem BD. US patent 2,789,138. 1957
11. Stowell JC, Padegimas SJ. Preparation of sterically hindered secondary amines. Synthesis 1974; 127-8
12. Buzas A, Dufour C. Sur la préparation de la β-(para-oxy-phényl)-isopropyl-méthyl-amine. Bull Soc Chim France 1950; 139-40