Cellular expression and regulation of iron transport and storage proteins in genetic haemochromatosis

Journal of Gastroenterology and Hepatology (Australia)

Volumn 13, Issue 6, 1998, Pages 624-634

  Basclain, Kerrie A ^a   Shilkin, Keith B ^b   Withers, Geoffrey ^c   Reed, William D ^a   Jeffrey, Gary P ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b Western Australian Centre for Pathology and Medical Research   (Australia)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Duodenum; Genetic haemochromatosis; Immunohistochemistry; In situ hybridization; Iron; Liver

Indexed keywords

FERRITIN; IRON; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ARTICLE; CLINICAL ARTICLE; DUODENUM BIOPSY; HEMOCHROMATOSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IRON DEFICIENCY; IRON METABOLISM; IRON OVERLOAD; IRON STORAGE; IRON TRANSPORT; LIVER BIOPSY; LIVER CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

EID: 0031784423     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.1998.tb00701.x     Document Type: Article

References (32)

1. Tavill AS, Bacon BR. Hemochromatosis: Iron metabolism and the iron overload syndromes. In: Zakim D, BoyerTD, eds. Hepatology. A textbook of liver disease. Vol. 2. 2nd ed. Philadelphia: WB Saunders Company, 1990; 1273-99.
2. Niederau C, Fischer R, Sonnenberg A, Stremmel W, Trampisch HJ, Strohmeyer G. Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N. Engl. J. Med. 1985; 313: 1256-62.
3. Powell LW, Campbell CB, Wilson E. Intestinal mucosal uptake of iron and iron retention in idiopathic haemochromatosis as evidence for a mucosal abnormality. Gut 1970; 11: 727-31.
4. Astaldi G, Meardi G, Lisino T. The iron content of jejunal mucosa obtained by Crosby's biopsy in hemochromatosis and hemosiderosis. Blood 1966; 28: 70-82.
5. Feder JN, Gnirke A, Thomas W et al. A novel MHC class 1-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet. 1996; 13: 399-408.
6. Rothenberg BE, Voland JR. ß2 Knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism. Proc. Natl Acad. Sci. USA 1996; 93: 1529-34.
7. Arosa FA, Dasilva AJ, Godinho IM et al. Decreased CD8-p561ck activity in peripheral blood T-lymphocytes from patients with hereditary hemochromatosis. Scand. J. Immmunol. 1994; 39: 426-32.
8. Lombard M, Bomford A, Hynes M et al. Regulation of the hepatic transferrin receptor in hereditary hemochromatosis. Hepatology 1989; 9: 1-5.
9. Banerjee D, Flanagan PR, Cluett J, Valberg LS. Transferrin receptors in the human gastrointestinal tract. Gastroenterology 1986; 91: 861-9.
10. Lombard M, Bomford AB, Polson RJ, Bellingham AJ, Williams R. Differential expression of transferrin receptor in duodenal mucosa in iron overload. Gastroenterology 1990; 98: 976-84.
11. Pietrangelo A, Rocchi E, Ferrari A, Ventura E, Cairo G. Regulation of hepatic transferrin, transferrin receptor and ferritin genes in human siderosis. Hepatology 1991; 14: 1083-9.
12. Pietrangelo A, Rocchi E, Casalgrandi G et al. Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum. Gastroenterology 1992; 102: 802-9.
13. Pietrangelo A, Casalgrandi G, Quaglino D et al. Duodenal ferritin synthesis in genetic hemochromatosis. Gastroenterology 1995; 108: 208-17.
14. Jeffrey GP, Basclain KA, Allen TL. Molecular regulation of transferrin receptor and ferritin expression in the rat gastrointestinal tract. Gastroenterology 1996; 110: 790-800.
15. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 1987; 162: 156-9.
16. Escriva H, Pierce A, Coddeville B et al. Rat mammarygland transferrin - nucleotide sequence, phylogenetic analysis and glycan structure. Biochem. J. 1995; 307: 47-55.
17. Jeffrey GP, Oates PS, Wang TC, Babyatsky M, Brand SJ. Spasmolytic peptide - A trefoil peptide secreted by rat gastric mucous cells. Gastroenterology 1994; 106: 336-45.
18. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain terminating inhibitors. Proc. Natl Acad. Sci. USA 1977; 74: 5463-7.
19. Sciot R, Paterson AC, Van Den Oord JJ, Desmet VJ. Lack of hepatic transferrin receptor expression in hemochromatosis. Hepatology 1987; 7: 831-7.
20. Batey RG, Pettit JE, Nicholas AW, Sherlock S, Hoffbrand AV. Hepatic iron clearance from serum in treated hemochromatosis. Gastroenterology 1978; 75: 856-9.
21. Hu W, Regoeczi E. Hepatic heparan sulphate proteoglycan and the recycling of transferrin. Biochem. Cell Biol. 1992; 70: 535-8.
22. Thorstensen K, Trinder D, Zak O, Aisen P. Uptake of iron from N-terminal half-transferrin by isolated rat hepatocytes - evidence of transferrin-receptor-independent iron uptake. Eur. J. Biochem. 1995; 232: 129-33.
23. Morgan EH, Baker E. The role of transferrin receptors and endocytosis in iron uptake by hepatic and erythroid cells. Ann. NY Acad. Sci. 1988; 526: 65-82.
24. Leibold EA, Guo B. Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding protein Annu. Rev. Nutr. 1992; 12: 345-68.
25. Flanagan PR, Hajdu A, Adams PC. Iron-responsive element-binding protein in hemochromatosis liver and intestine. Hepatology 1995; 22: 828-32.
26. Beaumont C, Leneuve P, Devaux I et al. Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract. Nature Genet. 1995; 11: 444-6.
27. Whittaker P, Skikne BS, Covell AM et al. Duodenal iron proteins in idiopathic hemochromatosis. J. Clin. Invest. 1989; 83: 261-7.
28. Cox LA, Adrian GS. Posttranscriptional regulation of chimeric human transferrin genes by iron. Biochemistry 1993; 32: 4738-45.
29. Aisen P. Iron in isolated liver cells. Ann. NY Acad. Sci. 1988; 526: 93-100.
30. Crosby WH, Conrad ME, Wheby MS. The rate of iron accumulation in iron storage disease. Blood 1963; 22: 429-40.
31. Fracanzani AL, Fargion S, Romano R et al. Immunohistochemical evidence for a lack of ferritin in duodenal absorptive epithelial cells in idiopathic hemochromatosis. Gastroenterology 1989; 96: 1071-8.
32. Skikne BS, Whittaker P, Cooke A, Cook JD. Ferritin excretion and iron balance in humans. Br. J. Haematol. 1995; 90: 681-7.