Elucidation of the exon-intron structure and size of the human protein kinase C beta gene (PRKCB)

Human Genetics

Volumn 103, Issue 4, 1998, Pages 483-487

  Greenham, Jaimie ^a   Adams, Mark ^b   Doggett, Norman ^c   Mole, Sara ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b Institute for Genome Research   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTIG; PROTEIN KINASE C;

ALTERNATIVE RNA SPLICING; ARTICLE; CHROMOSOME 16P; DROSOPHILA MELANOGASTER; EXON; GENE STRUCTURE; HAPLOIDY; HUMAN; INTRON; OPEN READING FRAME; PRIORITY JOURNAL;

BLOTTING, SOUTHERN; COSMIDS; EXONS; HUMANS; INTRONS; ISOENZYMES; POLYMERASE CHAIN REACTION; PROTEIN KINASE C;

EID: 0031784154     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050854     Document Type: Article

References (16)

1. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-410
2. Blobe GC, Stribling S, Fabbro D, Stabel S, Hannun YA (1996) Protein kinase BII specifically binds to and is activated by F-actin. J Biol Chem 271:15823-15830
3. Callen DF, Doggett N A, Stallings RL, Chen LZ, Whitmore SA, Lane SA, Nancarrow JK, Apostolou S, Thompson AD, Lapsys NM, Eyre HJ, Baker EG, Shen Y, Holman K, Phillips H, Richards RI, Sutherland GR (1992) High-resolution cytogenetic-based physical map of human chromosome 16. Genomics 13:1178-1185
4. Coussens L, Parker PJ, Rhee L, Yang Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A (1986) Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science 233:859-866
5. Coussens L, Rhee L, Parker PJ, Ullrich A (1987) Alternative splicing increases the diversity of the human protein kinase C family. DNA 6:389-394
6. Dekker LV, Palmer RH, Parker PJ (1995) The protein kinase C and protein kinase C related gene families. Curr Opin Struct Biol 5:396-402
7. Doggett NA, Goodwin LA, Tesmer JG, Meincke LJ, Bruce DC, Clark LM, Altherr MR, Ford AA, Chi HC, Marrone BL, Longmire JL, Lane SA, Whitmore SA, Lowenstein MF, Sutherland RD, Mundt MO, Knill EH, Bruno WJ, Macken CA, Torney DC, Wu JR, Griffith J, Sutherland GR, Deaven LL, Callen DF, Moyzis RK (1995) An integrated physical map of human chromosome 16. Nature 377:335-365
8. Hug H, Sarre TF (1993) Protein kinase C isoenzymes: divergence in signal transduction. Biochem J 291:329-343
9. Korn B, Sedlacek Z, Manca A, Kioschis P, Konecki D, Lehrach H, Poustka A (1992) A strategy for the selection of transcribed sequences in the Xq28 region. Hum Mol Genet 1:235-242
10. Kubo K, Oh no S, Suzuki K (1987) Nucleotide sequence of the 3′ portion of a human gene for protein kinase C beta I/beta II. Nucleic Acids Res 15:7179-7180
11. Longmire JL (1993) Construction and characterisation of partial digest DNA libraries made from flow-sorted human chromosome 16. Genet Anal Tech Appl 10:69-76
12. Mahajna J, King P, Parker P, Haley J (1995) Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells. DNA Cell Biol 14:213-222
13. Mole SE, Mulligan LM, Healey CS, Ponder BAJ, Tunnacliffe A (1993) Localisation of the gene for multiple endocrine neoplasia type 2A to a 480 kb region in chromosome band 10q11.2. Hum Mol Genet 2:247-252
14. Nishizuka Y (1992) Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-614
15. Obeid LM, Blobe GC, Karolak LA, Hannun YA (1992) Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. J Biol Chem 267:20804-20810
16. Rosenthal A, Rhee L, Yadegari R, Paro R, Ullrich A, Goeddel DV (1987) Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene. EMBO J 6:433-441