An efficient synthesis of 2-ethyl-7-chloro-4-methylthieno[4,3,2- e,f][3]benzazepine (SK and F 106686) via bromomethylation of 2-ethyl-5- chlorobenzo[b]thiophene

Synthetic Communications

Volumn 28, Issue 18, 1998, Pages 3479-3489

  Pridgen, Lendon N ^a   Huang, Kris ^a   Mills, Robert J ^a   Shilcrat, Susan ^a   Tickner, Ann ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYL 7 CHLORO 4 METHYLTHIENO[4,3,2 E,F][3]BENZAZEPINE; ANGIOTENSIN II ANTAGONIST; BENZOTHIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG SYNTHESIS; METHYLATION; PHASE TRANSITION;

EID: 0031784117     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397919808004456     Document Type: Article

References (15)

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14. Careful GC/MS analysis of the gases above the reaction solution failed to detect the presence of potentially carginogenic bromomethyl ether derivatives (see ref. 8).
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