Impact of inhaled nitric oxide on platelet aggregation and fibrinolysis in rats with endotoxic lung injury: Role of cyclic guanosine 5'-monophosphate

American Journal of Respiratory and Critical Care Medicine

Volumn 158, Issue 3, 1998, Pages 833-839

  Kermarrec, Nathalie ^b   Zunic, Patricia ^b   Beloucif, Sadek ^b   Benessiano, Joëlle ^b   Drouet, Ludovic ^b   Payen, Didier ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; ENDOTOXIN; FIBRINOGEN; NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING TIME; BLOOD CLOT LYSIS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FIBRINOLYSIS; HEMOSTASIS; INHALATIONAL DRUG ADMINISTRATION; LUNG INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

EID: 0031783795     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.158.3.9709097     Document Type: Article

References (36)

1. Mizutani, T., and A. J. Layon. 1996. Clinical applications of nitric oxide. Chest 110:506-524.
2. Rossaint, R., K. J. Falke, F. Lopez, K. Slama, U. Pison, and W. M. Zapol. 1993. Inhaled nitric oxide for the adult respiratory distress syndrome. N. Engl. J. Med. 328:399-405.
3. Chollet-Martin, S., C. Gatecel, N. Kermarrec, M. A. Gougerot-Pocidalo, and D. M. Payen. 1996. Alveolar neutrophil functions and cytokine levels in patients with the adult respiratory distress syndrome during nitric oxide inhalation. Am. J. Respir. Crit. Care Med. 153:985-990.
4. Lander, H. M., P. Sehajpal, D. M. Levine, and A. Novogrodsky. 1993. Activation of human peripheral blood mononuclear cells by nitric oxide - generating compounds. J. Immunol. 150:1509-1516.
5. Mellion, B. T., L. J. Ignarro, E. H. Ohlstein, E. G. Pontecorvo, A. L. Hyman, and P. J. Kadowitz. 1981. Evidence for the inhibitory role of guanosine 3′,5′-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood 57:946-955.
6. Högrnan, M., C. Frostell, H. Arnberg, and G. Hedenstierna. 1993. Bleeding time prolongation and NO inhalation. Lancet 341:1664-1665.
7. Samama, C. M., M. Diaby, J. L. Fellahi, A. Mdhafar, D. Eyraud, M. Arock, J. J. Guillosson, P. Coriat, and J. J. Rouby. 1995. Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 83:56-65.
8. Malik, A. B. 1990. Pulmonary microembolism and lung vascular injury. Eur. Respir. J. 3:499s-506s.
9. Nelson, S., J. B. Bagby, B. G. Bainton, L. A. Wilson, J. J. Thompson, and W. R. Summer. 1989. Compartmentalization of intraalveolar and systemic lipopolysaccharide induced tumor necrosis factor and the pulmonary inflammatory response. J. Infect. Dis. 159:189-194.
10. Dejana, E., S. Villa, and G. De Gaetano. 1982. Bleeding time in rats: a comparison of different experimental conditions. Thromb. Haemost. 48: 108-111.
11. Born, G. V. R., and M. J. Cross. 1963. The aggregation of blood platelets. J. Physiol. 168:178-195.
12. Groves, P. H., M. J. Lewis, H. A. Cheadle, and W. J. Penny. 1993. SIN-1 reduces platelet adhesion and platelet thrombus formation in a porcine model of balloon angioplasty. Circulation 87:590-597.
13. von Kaulla, K. N., R. L. Schultz. 1958. Methods for the evaluation of human fibrinolysis: studies with two combined technics. Am. J. Clin. Path. 29:104-112.
14. Högman, M., C. Frostell, H. Arnberg, B. Sandhagen, and G. Hedenstierna. 1994. Prolonged bleeding time during nitric oxide inhalation in the rabbit. Acta Physiol. Scand. 151:125-129.
15. Albert, J., N. H. Wallen, A. Broijersen, C. Frostell, and P. Hjemdahl. 1996. Effects of inhaled nitric oxide compared with aspirin on platelet function in vivo in healthy subjects. Clin. Sci. 91:225-231.
16. Adrie, C., K. D. Bloch, P. R. Moreno, W. E. Hurford, J. L. Guerrero, R. Holt, W. M. Zapol, H. K. Gold, and M. J. Semigran. 1996. Inhaled nitric oxide increases coronary artery patency after thrombolysis. Circulation 94:1919-1926.
17. Gries, A., B. W. Böttiger, J. Dörsam, H. Bauer, J. Weimann, C. Bode, E. Martin, and J. Motsch. 1997. Inhaled nitric oxide inhibits platelet aggregation after pulmonary embolism in pigs. Anesthesiology 86:387-393.
18. Fox-Dewhurst, R., M. K. Alberts, O. Kajikawa, E. Caldwell, M. C. Johnson, II, S. J. Skerrett, R. B. Goodman, J. T. Ruzinski, V. A. Wong, A. Y. Chi, and T. R. Martin. 1997. Pulmonary and systemic inflammatory responses in rabbits with gram-negative pneumonia. Am. J. Respir. Crit. Care Med. 155:2030-2040.
19. Pittet, J. F., R. C. Mackersie, and M. A. Matthay. 1997. Biological markers of acute lung injury: prognostic and pathogenetic significance. Am. J. Respir. Crit. Care Med. 155:1187-1205.
20. Hasegawa, N., A. W. Husari, W. T. Hart, T. G. Kandra, and T. A. Raffin. 1994. Role of the coagulation system in ARDS. Chest 105:268-277.
21. Christou, H., I. Adatia, L. J. Van Marter, J. W. Kane, J. E. Thompson, A. R. Stark, D. L. Wessel, and S. Kourembanas. 1997. Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5′-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension. J. Pediatr. 130:603-611.
22. Rovira, I., T. Y. Chen, M. Winkler, N. Kawai, K. D. Bloch, and W. M. Zapol. 1994. Effects of inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of ARDS. J. Appl. Physiol. 76:345-355.
23. Nong, Z., M. Hoylaerts, N. Van Pelt, D. Collen, and S. Janssens. 1997. Nitric oxide inhalation inhibits platelet aggregation and platelet-mediated pulmonary thrombosis in rats. Circ. Res. 81:865-869.
24. Stamler, J. S., D. I. Simon, J. A. Osborne, M. E. Mullins, O. Jaraki, T. Michel, D. J. Singel, and J. Loscalzo. 1992. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc. Natl. Acad. Sci. U.S.A. 89:444-448.
25. Stamler, J. S., D. J. Singel, and J. Loscalzo. 1992. Biochemistry of nitric oxide and its redox activated forms. Science 258:1898-1902.
26. Radomski, M. W., R. M. J. Palmer, and S. Moncada. 1990. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc. Natl. Acad. Sci. U.S.A. 87:5193-5197.
27. Radomski, M. W., and S. Moncada. 1993. Regulation of vascular homeostasis by nitric oxide. Thromb. Haemost. 70:36-41.
28. Griffiths, M. J. D., S. Liu, N. P. Curzen, M. Messent, and T. W. Evans. 1995. In vivo treatment with endotoxin induces nitric oxide synthase in rat main pulmonary artery. Am. J. Physiol. 268:L509-L518.
29. Umans, J. G., M. E. Wylam, R. W. Samsel, J. Edwards, and P. T. Schumacker. 1993. Effects of endotoxin in vivo on endothelial and smooth-muscle function in rabbit and rat aorta. Am. Rev. Respir. Dis. 148:1638-1645.
30. Kurrek, M. M., L. Castillo, K. D. Bloch, S. R. Tannenbaum, and W. M. Zapol. 1995. Inhaled nitric oxide does not alter endotoxin-induced nitric oxide synthase activity during rat lung perfusion. J. Appl. Physiol. 79:1088-1092.
31. Loscalzo, J., and E. Braunwald. 1988. Tissue plasminogen activator. N. Engl. J. Med. 319:925-931.
32. Sprengers, E. D., and C. Kluft. 1987. Plasminogen activator inhibitors. Blood 69:381-387.
33. Grodzinska, L., G. Hafner, and H. Darius. 1990. Effect of molsidomine on t-PA and PAI activity in man: a double blind, placebo controlled study. Thromb. Haemost. 64:485.
34. Lidbury, P. S., R. Korbut, and J. R. Vane. 1990. Sodium nitroprusside modulates the fibrinolytic system in the rabbit. Br. J. Pharmacol. 101: 527-530.
35. Tranquille, N., and J. J. Emeis. 1993. The role of cyclic nucleotides in the release of tissue-type plasminogen activator and von Willebrand factor. Thromb. Haemost. 69:259-261.
36. Suffredini, A. F., P. C. Harpel, and J. E. Parrillo. 1989. Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects. N. Engl. J. Med. 320:1165-1172.