Downregulation of ventricular contractile function during early ischemia is flow but not pressure dependent

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 5 44-5, 1998, Pages

  He, Miao Xiang ^a   Downey, H Fred ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Coronary flow; Coronary pressure; Vascular collapse

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLLAPSE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY OBSTRUCTION; CORONARY ARTERY PRESSURE; DOWN REGULATION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART RATE; HEART VENTRICLE CONTRACTILITY; HEART VENTRICLE FUNCTION; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RAT;

EID: 0031782877     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.5.h1520     Document Type: Article

References (14)

1. Bai, X.-J., T. Iwamoto, A. G. Williams, Jr., W.-L. Fan, and H. F. Downey. Coronary pressure-flow autoregulation protects myocardium from pressure-induced changes in oxygen consumption. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H2359-H2368, 1994.
2. Bristow, J. D., A. E. Arai, C. G. Anselone, and G. A. Pantely. Response to myocardial ischemia as a regulated process. Circulation 84: 2580-2587, 1991.
3. Canty, J. M., Jr. Coronary pressure-function and steady-state pressure-flow relations during autoregulation in the unanesthetized dog. Circ. Res. 63: 821-836, 1988.
4. Clark, K., A. J. O'Connor, and R. J. Willis. Temporal relation between energy metabolism and myocardial function during ischemia and reperfusion. Am. J. Physiol. 253 (Heart Circ. Physiol. 22): H412-H421, 1987.
5. Drew, J. S., V. A. Harwalkar, and L. A. Stein. Product inhibition of the actomyosin subfragment-1 ATPase in skeletal, cardiac, and smooth muscle. Circ. Res. 71: 1067-1077, 1992.
6. Galilnanes, M., D. J. Hearse, and M. J. Shattock. The role of the rate of vascular collapse in ischemia-induced acute contractile failure and decreased diastolic stiffness. J. Mol. Cell. Cardiol. 28: 519-529, 1996.
7. Harvey, W. Anatomical Studies on the Motion of the Heart and Blood (1628), translated by C. D. Leak. Springfield, IL: Thomas, 1970.
8. He, M.-X., S. Wang, and H. F. Downey. Correlation between myocardial contractile force and cytosolic inorganic phosphate during early ischemia. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H1333-H1341, 1997.
9. Kentish, J. C., and D. G. Allen. Is force production in the myocardium directly dependent upon the free energy change of ATP hydrolysis? J. Mol. Cell. Cardiol. 18: 879-882, 1986.
10. Koretsune, Y., M. C. Corretti, H. Kusuoka, and E. Marban. Mechanism of early ischemic contractile failure. Inexcitability, metabolite accumulation, or vascular collapse? Circ. Res. 68: 255-262, 1991.
11. Lionne, C., M. Brune, M. R. Webb, F. Travers, and T. Barman. Time resolved measurements show that phosphate release is the rate limiting step on myofibrillar ATPases. FEBS Lett. 364: 59-62, 1995.
12. Ross, J., Jr. Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation. Circulation 83: 1076-1083, 1991.
13. Schmidt-Ott, S. C., C. Bletz, C. Vahl, W. Saggau, S. Hagl, and J. C. Ruegg. Inorganic phosphate inhibits contractility and ATPase activity in skinned fibers from human myocardium. Basic Res. Cardiol. 85: 358-366, 1990.
14. Xiang, J. Z., and J. C. Kentish. Effects of inorganic phosphate and ADP on calcium handling by the sarcoplasmic reticulum in rat skinned cardiac muscle. Cardiovasc. Res. 29: 391-400, 1995.