-
1
-
-
0029164564
-
ZD1694 (Tomudex): A new thymidylate synthase inhibitor with activity in colorectal cancer
-
Jackman AL, Farrugia DC, Gibson W, et al. ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancer. Eur J Cancer 1995, 31A(7/8), 1277-1282.
-
(1995)
Eur J Cancer
, vol.31 A
, Issue.7-8
, pp. 1277-1282
-
-
Jackman, A.L.1
Farrugia, D.C.2
Gibson, W.3
-
2
-
-
5544237608
-
® (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer
-
® (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. Ann Oncol 1996, 7, 961-965.
-
(1996)
Ann Oncol
, vol.7
, pp. 961-965
-
-
Cunningham, D.1
Zalcberg, J.R.2
Rath, U.3
-
3
-
-
0029931840
-
"tomudex" (ZD 1694): A novel thymidylate synthase inhibitor with clinical antitumour activity in a range of solid tumours
-
Cunningham D, Zalcberg J, Smith I, et al. "Tomudex" (ZD 1694): a novel thymidylate synthase inhibitor with clinical antitumour activity in a range of solid tumours. Ann Oncol 1996, 7, 179-182.
-
(1996)
Ann Oncol
, vol.7
, pp. 179-182
-
-
Cunningham, D.1
Zalcberg, J.2
Smith, I.3
-
4
-
-
0029930070
-
Resistance to Tomudex (ZD1694): Multifactorial in human breast and colon carcinoma cell lines
-
Drake J.C., Allegra C.J., Moran R.G., Johnston P.G. Resistance to Tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines. Biochem Pharmacol. 51:1996;1349-1355.
-
(1996)
Biochem Pharmacol
, vol.51
, pp. 1349-1355
-
-
Drake, J.C.1
Allegra, C.J.2
Moran, R.G.3
Johnston, P.G.4
-
5
-
-
0029156922
-
Thymidylate synthase and drug resistance
-
Peters GJ, Van der Wilt CL, Triest B van, et al. Thymidylate synthase and drug resistance. Eur J Cancer 1995, 31A(7/8), 1299-1305.
-
(1995)
Eur J Cancer
, vol.31 A
, Issue.7-8
, pp. 1299-1305
-
-
Peters, G.J.1
Van Der Wilt, C.L.2
Van Triest, B.3
-
6
-
-
0026637845
-
Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules
-
Aschele C., Sobrero A., Faderan M.A., Bertino J.R. Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res. 51:1992;1855-1864.
-
(1992)
Cancer Res
, vol.51
, pp. 1855-1864
-
-
Aschele, C.1
Sobrero, A.2
Faderan, M.A.3
Bertino, J.R.4
-
7
-
-
0031015454
-
Fluorouracil in colorectal cancer - A tale of two drugs: Implications for biochemical modulation
-
Sobrero A.F., Aschele C., Bertino J.R. Fluorouracil in colorectal cancer - a tale of two drugs: implications for biochemical modulation. J Clin Oncol. 15:(1):1997;368-381.
-
(1997)
J Clin Oncol
, vol.15
, Issue.1
, pp. 368-381
-
-
Sobrero, A.F.1
Aschele, C.2
Bertino, J.R.3
-
8
-
-
9044245305
-
ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer
-
Zalcberg JR, Cunningham D, Van Cutsem E, et al. ZD1694: a novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. J Clin Oncol 1996, 14(3), 716-721.
-
(1996)
J Clin Oncol
, vol.14
, Issue.3
, pp. 716-721
-
-
Zalcberg, J.R.1
Cunningham, D.2
Van Cutsem, E.3
-
9
-
-
0344503902
-
A pharmacodynamic study of the thymidylate synthase inhibitor Tomudex in advanced colorectal cancer (abstract)
-
Farrugia D, Cunningham D, Danenberg P, et al. A pharmacodynamic study of the thymidylate synthase inhibitor Tomudex in advanced colorectal cancer (abstract). Proc Am Assoc Cancer Res 1997, 38, 615.
-
(1997)
Proc Am Assoc Cancer Res
, vol.38
, pp. 615
-
-
Farrugia, D.1
Cunningham, D.2
Danenberg, P.3
-
10
-
-
0001139165
-
Phase I trial of ZD1694 (Tomudex), a direct inhibitor of thymidylate synthase
-
Sorensen JM, Jordan E, Grem JL , et al. Phase I trial of ZD1694 (Tomudex), a direct inhibitor of thymidylate synthase. Ann Oncol 1994, 5(Suppl. 5), 132.
-
(1994)
Ann Oncol
, vol.5
, Issue.SUPPL. 5
, pp. 132
-
-
Sorensen, J.M.1
Jordan, E.2
Grem, J.L.3
-
11
-
-
0001826735
-
Interactions and cross resistance patterns between various schedules of 5-FU and the new, folate-based thymidylate synthase inhibitor Tomudex (D1694)
-
Harstrick A, Schleucher N, Gonzales A, et al. Interactions and cross resistance patterns between various schedules of 5-FU and the new, folate-based thymidylate synthase inhibitor Tomudex (D1694). Eur J Cancer 1995, 31A(5), S30.
-
(1995)
Eur J Cancer
, vol.31 A
, Issue.5
-
-
Harstrick, A.1
Schleucher, N.2
Gonzales, A.3
-
12
-
-
0028787690
-
Fluorouracil: Active in ZD1694 (Tomudex)-resistant cell lines with markedly elevated thymidylate synthase levels
-
Johnston P.G., Behan K.A., Allegra C.J., Drake J.C. Fluorouracil: active in ZD1694 (Tomudex)-resistant cell lines with markedly elevated thymidylate synthase levels. J Natl Cancer Inst. 87:(20):1995;1558-1559.
-
(1995)
J Natl Cancer Inst
, vol.87
, Issue.20
, pp. 1558-1559
-
-
Johnston, P.G.1
Behan, K.A.2
Allegra, C.J.3
Drake, J.C.4
-
13
-
-
0027317751
-
Decreased folylpolyglutamate synthase expression: A novel mechanism of fluorouracil resistance
-
Wang F.S., Achele C., Sobrero A., Chang Y.M., Bertino J.R. Decreased folylpolyglutamate synthase expression: a novel mechanism of fluorouracil resistance. Cancer Res. 53:1993;3677-3680.
-
(1993)
Cancer Res
, vol.53
, pp. 3677-3680
-
-
Wang, F.S.1
Achele, C.2
Sobrero, A.3
Chang, Y.M.4
Bertino, J.R.5
-
14
-
-
0345366123
-
A prospective randomised trial of protracted venous infusion (PVI) 5-FU with or without mitomycin C in advanced colorectal cancer
-
Ross P, Norman A, Cunningham D, et al. A prospective randomised trial of protracted venous infusion (PVI) 5-FU with or without mitomycin C in advanced colorectal cancer. Br J Cancer 1997, 76(1), 32.
-
(1997)
Br J Cancer
, vol.76
, Issue.1
, pp. 32
-
-
Ross, P.1
Norman, A.2
Cunningham, D.3
-
15
-
-
0031014627
-
Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy
-
Rougier P, Bugat R, Douillard JY, et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol 1997, 15(1), 251-260.
-
(1997)
J Clin Oncol
, vol.15
, Issue.1
, pp. 251-260
-
-
Rougier, P.1
Bugat, R.2
Douillard, J.Y.3
-
16
-
-
10344253782
-
Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil, and leucovorin in patients with metastatic colorectal cancer
-
Bertheault-Cvitkovic F, Jami A, Ithzaki M, et al. Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil, and leucovorin in patients with metastatic colorectal cancer. J Clin Oncol 1996, 14(11), 2950-2958.
-
(1996)
J Clin Oncol
, vol.14
, Issue.11
, pp. 2950-2958
-
-
Bertheault-Cvitkovic, F.1
Jami, A.2
Ithzaki, M.3
-
17
-
-
0028323029
-
Trial of sequential trimetrexate, fluorouracil, and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma
-
Conti JA, Kemeny N, Seiter K, et al. Trial of sequential trimetrexate, fluorouracil, and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma. J Clin Oncol 1994, 12(4), 695-700.
-
(1994)
J Clin Oncol
, vol.12
, Issue.4
, pp. 695-700
-
-
Conti, J.A.1
Kemeny, N.2
Seiter, K.3
|