Endothelial dysfunction in human intramyocardial small arteries in atherosclerosis and hypercholesterolemia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 4 44-4, 1998, Pages

  Cooper, Anne ^a,b   Heagerty, Anthony M ^a  

^a MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^b HOPE HOSPITAL   (United Kingdom)

Author keywords

Endothelium derived relaxing factor; Microcirculation

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; BRADYKININ; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CORONARY ARTERY BLOOD FLOW; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; MICROCIRCULATION; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0031782265     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.4.h1482     Document Type: Article

References (25)

1. Chilian, W. M., C. L. Eastham, and M. L. Marcus. Microvascular distribution of coronary resistance in beating left ventricle. Am. J. Physiol. 251 (Heart Circ. Physiol. 20): H779-H788, 1986.
2. Cohen, R. A., K. M. Zitnay, C. C. Haudenschild, and L. D. Cunningham. Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. Circ. Res. 63: 903-910, 1988.
3. Donomue, I., Y. Matsumoto, and E. Ueda. Significance of coronary arteriosclerosis in the intramuscular coronary arteries. Geriatrics 20: 179-193, 1965.
4. Drexler, H., D. Hayoz, T. Munzel, B. Hornig, H. Just, H. R. Brunner, and R. Zelis. Endothelial function in chronic congestive heart failure. Am. J. Cardiol. 69: 1596-1601, 1992.
5. Drexler, H., A. M. Zeiher, K. Meinzer, and H. Just. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet 338: 1546-1550, 1991.
6. Egashira, K., T. Inou, Y. Hirooka, A. Yamada, Y. Maruoka, H. Kai, M. Sugimachi, S. Suzuki, and A. Takeshita. Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions. J. Clin. Invest. 91: 29-37, 1993.
7. Förstermann, U., A. Mügge, U. Alheid, A. Haverich, and J. C. Frölich. Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries. Circ. Res. 62: 185-190, 1988.
8. Goode, G. K., and A. M. Heagerty. In vitro responses of human peripheral small arteries in hypercholesterolemia and effects of therapy. Circulation 91: 2898-2903, 1995.
9. Groves, P., S. Kurz, J. Just, and H. Drexler. Role of endogenous bradykinin in human coronary vasomotor control. Circulation 92: 3424-3430, 1995.
10. Heistad, D. D., M. L. Armstrong, M. L. Marcus, D. J. Piegors, and A. L. Mark. Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys. Circ. Res. 54: 711-718, 1984.
11. Inoue, T., Y. Sakai, S. Morooka, T. Hayashi, K. Takayanagi, H. Yamaguchi, H. Kakoi, and Y. Takabatake. Vasodilatory capacity of coronary resistance vessels in dilated cardiomyopathy.Am. Heart J. 127: 376-381, 1994.
12. Katz, S. D., L. Biasucci, C. Sabba, J. A. Strom, G. Jondeau, M. Galvao, S. Colomon, S. D. Nikolic, R. Forman, and T. H. LeJemtel. Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure. J. Am. Coll. Cardiol. 19: 918-925, 1992.
13. Kuo, L., M. J. Davis, M. S. Cannon, and W. M. Chilian. Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Circ. Res. 70: 465-476, 1992.
14. Ludmer, P. L., A. P. Selwyn, T. L. Shook, R. R. Wayne, G. H. Mudge, R. W. Alexander, and P. Ganz. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N. Engl. J. Med. 315: 1046-1051, 1986.
15. Luscher, T. F. Endothelium-derived relaxing and contracting factors: potential role in coronary artery disease. Eur. Heart J. 10: 847-857, 1989.
16. Minor, R. L., P. R. Myers, R. Guerra, J. N. Bates, and D. G. Harrison. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J. Clin. Invest. 86: 2109-2116, 1990.
17. Mügge, A., J. H. Elwell, T. E. Peterson, T. G. Hofmeyer, D. D. Heistad, and D. G. Harrison. Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent relaxation in cholesterol-fed rabbits. Circ. Res. 69: 1293-1300, 1991.
18. Mulvany, M. J., and W. Halpern. Contractile properties of small arterial resistance vessels in spontaneous and normotensive rats. Circ. Res. 41: 19-26, 1977.
19. Mulvany, M. J., P. K. Hansen, and C. Aalkjaer. Direct evidence that the greater contractility of resistance vessels in SHR is associated with narrowed lumen, a thicker media and an increased number of smooth muscle layers. Circ. Res. 43: 854-864, 1978.
20. Nakamura, M., H. Yoshida, N. Arakawa, Y. Mizunuma, S. Makita, and K. Hiramori. Endothelium-dependent vasodilation is not selectively impaired in patients with chronic heart failure secondary to valvular heart disease and congenital disease. Eur. Heart J. 17: 1875-1881, 1996.
21. Sellke, F. W., M. L.Armstrong, and D. G. Harrison. Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation 81: 1586-1593, 1990.
22. Shimokawa, H., N. A. Flavahan, and P. M. Vanhoutte. Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries. Circulation 83: 652-660, 1991.
23. Shimokawa, H., and P. M. Vanhoutte. Impaired endotheliumdependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circ. Res. 64: 900-914, 1989.
24. Treasure, C. B., J. A. Vita, D. A. Cox, R. D. Fish, J. B. Gordon, G. H. Mudge, W. S. Colucci, M. G. Sutton, A. P. Selwyn, R. W. Alexander, and P. Ganz. Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy. Circulation 81: 772-779, 1990.
25. Zeiher, A. M., H. Drexler, H. Wollschlager, and H. Just. Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 83: 391-401, 1991.