Differential effects of inhaled budesonide on serum osteocalcin in children and adolescents with asthma

Pediatric Allergy and Immunology

Volumn 9, Issue 3, 1998, Pages 150-155

  Wolthers, Ole D ^a,b   Heuck, Carsten ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b RANDERS REGIONAL HOSPITAL   (Denmark)

Author keywords

Adolescents; Asthma; Children; Inhaled budesonide; Osteocalcin

Indexed keywords

ANTIASTHMATIC AGENT; BUDESONIDE; OSTEOCALCIN;

ARTICLE; ASTHMA; BONE TURNOVER; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; PREPUBERTY; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SERUM;

EID: 0031781999     PISSN: 09056157     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3038.1998.tb00362.x     Document Type: Article

References (32)

1. NIELSEN HK. Circadian and circatrigentan changes in osteoblastic activity assessed by serum osteocalcin [thesis]. Copenhagen: Laegeforeningens forlag, 1993.
2. RIIS BJ, KRABBE S, CHRISTIANSEN C, CATHERWOOD BD, DEFTOS LJ. Bone turnover in male puberty: a longitudinal study Calcif Tissue Int 1995: 37: 213-217.
3. JOHANSEN JS, GIWERCMAN A, HARTWELL D, et al. Serum bone gla-protein as a marker of bone growth in children and adolescents: correlation with age, height, serum insulin-like growth factor-I, serum testosterone. J Clin Endocrinol Metab 1988: 67: 273-278.
4. HODSMAN AB, TOOGOOD JH, JENNINGS B, FRAHER LJ, BASKERVILLE JC. Differential effects of inhaled budesonide and oral prednisolone on serum osteocalcin. J Clin Endocrinol Metab 1991: 72: 530-540.
5. WOLTHERS OD, RIIS BJ, PEDERSEN S. Bone turnover in asthmatic children treated with oral prednisolone or inhaled budesonide. Pediatr Pulmonol 1993: 16: 341-346.
6. TEELUCKSINGH S, PADFIELD PL, TIBI L, COUGH KJ, HOLT PR. Inhaled corticosteroids, bone formation, osteocalcin. Lancet 1991: 338: 60-61.
7. POUW EM, PRUMMEL MF, OOSTING H, Roos CM, ENDERT E. Beclomethasone inhalation decreases serum osteocalcin concentrations. Br Med J 1991: 302: 627-628.
8. SORVA R, TURPELNEN M, JUNTUNEN-BACKMAN K, KARONEN SL, SORVA A. Effects of inhaled budesonide on serum markers of bone metabolism in children with asthma. J Allergy Clin Immunol 1992: 90: 808-815.
9. KONIG P, HILLMAN L, CERVANTES C, et al. Bone metabolism in children with asthma treated with inhaled beclomethasone dipropionate. J Pediatrics 1993: 122: 219-226.
10. BIRKEBÆK NH, ESBERG G, ANDERSEN K, WOLTHERS OD, HASSAGER C. Bone and collagen turnover during treatment with inhaled budesonide and beclomethasone dipropionate. Arch Dis Child 1995: 73: 524-527.
11. TANNER JM. Growth at Adolescence. Oxford: Blackwell, 1962.
12. MASTERS PW, JONES RG, PURVES DA, COOPER EH, COONEY JM. Commercial osteocalcin assays give clinically discordant results. Clin Chem 1994: 40: 358-363.
13. DIEGO MED, GUERRERO R, PIEDRA CDL. Six osteocalcin assays compared. Clin Chem 1994: 40: 2071-2077.
14. KABI PHARMACIA DIAGNOSTICS AB. Pharmacia CAP system osteocalcin FEIA. Uppsala: Kabi Pharmacia Diagnostics AB 1994.
15. TARALLO P, HENNY J, FOURNIER B, SIEST G. Plasma osteocalcin: biological variations and reference limits. Scand J Clin Lab Invest 1990: 50: 649-655.
16. GUNDBERG CM, MARKOWITZ ME, MIZRUCHI M, ROSEN JF. Osteocalcin in human serum: a circadian rhythm. J Clin Endocrinol Metab 1987: 60: 736-739.
17. HILLS M, ARMITAGE P. The two-period cross over clinical trial. Br J Clin Pharmacol 1977: 8: 7-20.
18. CECCHETTIN M, BELLOMETTI S, TORRI G, GALZIGNA L. Comparison of commercial osteo calcin assay kits in evaluating osteoporosis. Cur Ther Res 1995: 56 (2): 163-168.
19. GARNERO P, GRIMAUX M, SEGUIN P, DELMAS PD. Characterization of immunoreactive forms of human osteocalcin generated in vivo and in vitro. J Bone Min Res 1994: 9 (2): 255-264.
20. BLUMSOHN A, HANNON RA, EASTELL R. Apparent instability of osteocalcin in serum as measured with different commercially available immunoassays. Clin Chem 1995: 41 (2): 318-319.
21. DELMAS PD, WOLFERT RL, HILL CS, BURTON DW. Two site assays of bone gla protein (osteocalcin) demonstrate immunochemical heterogeneity of the intact molecule. Clin Chem 1992: 38: 2318-2321.
22. DOULL I, FREEZER N, HOLGATE S. Osteocalcin, growth, inhaled corticosteroids: a prospective study. Arch Dis Child 1996: 74: 497-501.
23. HOEKX JCM, HEDLIN G, PEDERSEN W, SORVA R, HOLLINGWORTH K, EFTHIMIOU J. Flutica- sone propionate compared with budesonide: a double-blind trial in asthmatic children using powder devices at a dosage of 400 μg per day. Eur Respir J 1996: 9: 2263-2272.
24. SORVA R, TÄHTELÄ R, TURPEINEN M, et al. Changes in bone markers in children with asthma during inhaled budesonide and nedocromil treatments. Acta Pædiatr 1996: 85: 1176-1180.
25. THOMSEN K, ERIKSEN EF, JØRGENSEN JCR, CHARLES P, MOSEKILDE L. Seasonal variation of serum bone gla protein. Scand J Clin Lab Invest 1989: 49: 605-611.
26. HEUCK C, WOLTHERS OD, HANSEN M, KOLLERUP G. Short term growth and collagen turnover in asthmatic adolescents treated with the inhaled glucocorticoid budesoni- DE. Steroids 1997: 62: 659-664.
27. RYRFELDT Å, ANDERSSON P, EDSBÄCKER S, TÖNNESON M, DAVIES D, PAUWELS R. Pharmacokinetics and metabolism of budesonide, a selective glucocorticoid. Eur J Resp Dis 1982: 63 (Suppl 122): 86-95.
28. PEDERSEN S, STEFFENSEN G, EKMAN I, TÖNNESON M, BORGÅ O. Pharmacokinetics of budesonide in children with asthma. Eur J Clin Pharmacol 1987: 31: 579-82.
29. BORGSTRÖM L. Methodological studies on lung deposition [thesis]. Uppsala: Acta Universitatis Upsaliensis, 1993: 30.
30. BYRON MA, JACKSON J, ANSELL BM. Effect of different corticosteroid regimens on hypothalamic-pituitary-adrenal axis and growth in juvenile chronic arthritis. J R Soc Med 1983: 76: 452-457.
31. LOCASCIO V, BONUCCI E, IMBIMBO, et al. Bone loss in response to long term Glucocorticoid therapy. Bone Miner 1990: 8: 39-51.
32. MARTINATI LC, BERTOLDO F, GASPERI E, MICELLI S, BONER AL. Effect on cortical and trabecular bone mass of different anti-inflammatory treatments in preadolescent children with chronic asthma. Am J Respir Crit Care Med 1996: 153: 232-236.