Isolation of RP 66453, a new secondary peptide metabolite from Streptomyces sp. useful as a lead for neurotensin antagonists

Journal of Antibiotics

Volumn 51, Issue 5, 1998, Pages 512-514

  Helynck, Gerard ^a   Dubertret, Catherine ^a   Frechet, Denise ^b   Leboul, Jean ^a  

^a SANOFI   (France)

^b Structural Analysis Department   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTENSIN; PEPTIDE DERIVATIVE; RP 66453; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ANTAGONISM; DRUG ISOLATION; DRUG STRUCTURE; FERMENTATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES;

STREPTOMYCES;

EID: 0031781863     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.51.512     Document Type: Article

References (4)

1. KALIVAS, P.: Neurotransmitter regulation of dopamine neurons in the ventral tegmental area. Brain Res. Rev. 18: 75-113, 1993
2. KITABGI, P.; F. CHECLER, J. MAZELLA & J. P. VINCENT: Pharmacology and biochemistry of neurotensin receptors. Rev. Clin. Basic Pharmacol. 5: 397-486, 1985
3. GOEDERT, M.; K. PITTAWAY, B. J. WILLIAMS & P. C. EMSON: Specific binding of tritiated neurotensin to rat brain membranes: characterization and regional distribution. Brain Research 304: 71-81, 1984
4. CLERC, F. F.; M. C. DUBROEUCQ, G. HELYNCK, J. LEBOUL & J. P. MARTIN (Rhône-Poulenc Rorer S. A.): Neurotensin antagonist peptides useful for treating e.g. psychoses, depression, Alzheimer's and Parkinson's diseases, schizoprenia, ulcers, acute pancreatitis and asthma. FR 2720066, November 24, 1995