Effects of kynurenine metabolites on the electrocorticographic activity in the rat

Journal of Neural Transmission

Volumn 105, Issue 2-3, 1998, Pages 147-160

  Yokoi, I ^a   Nishijima, Y ^b   Uchida, A ^a   Kabuto, H ^a   Yamamoto, N ^a   Ogawa, N ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

3 hydroxyanthranilic acid; Electrocorticogram; Experimental epilepsy; o aminophenol; Seizure activity; Tryptophan kynurenine metabolites

Indexed keywords

3 HYDROXYANTHRANILIC ACID; ANTHRANILIC ACID; KYNURENIC ACID; KYNURENINE; PICOLINIC ACID; QUINALDIC ACID; XANTHURENIC ACID;

ANIMAL EXPERIMENT; ARTICLE; ELECTROCORTICOGRAPHY; MALE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031781781     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050044     Document Type: Article

References (42)

1. Beal MF, Matson WR, Swartz KJ, Gamache PH, Bird ED (1990) Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid. J Neurochem 55: 1327-1339
2. Birch PJ, Grossman CJ, Hayes AG (1988) Kynurenic acid antagonises responses to NMDA via an action at the strychinine-sensitive glycine receptor. Eur J Pharmacol 154: 85-87
3. Conick JH, Carl V, Moroni F, Stone TW (1989) Increase in kynurenic acid in Huntington's disease motor cortex. J Neurochem 52: 985-987
4. Danysz W, Fadda E, Wroblewski JT, Costa E (1989) Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the N-methyl-D-aspartate-sensitive glutamate receptor domain. Neurosci Lett 96: 340-344
5. Foldes A, Costa E (1975) Relationship of brain monoamine and locomotor activity in rats. Biochem Pharmacol 24: 1617-1621
6. Foster AC, Vezzani A, French ED, Schwarcz R (1984a) Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite in the rat. Exp Neurol 84: 428-440
7. Foster AC, Miller LP, Oldendorf WH, Schwarcz R (1984b) Studies on the disposition of quinolinic acid after intracerebral or systemic administration quinolinic acid. Neurosci Lett 48: 273-278
8. Foster AC, White RJ, Schwarcz R (1986) Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro. J Neurochem 47: 23-30
9. Gál EM, Sherman AD (1978) Synthesis and metabolism of L-kynurenine in rat brain. J Neurochem 30: 607-613
10. Gál EM, Sherman AD (1980) L-Kynurenine: its synthesis and possible regulatory function in brain. Neurochem Res 5: 223-239
11. Ganong AH, Lanthron TH, Cotman CW (1983) Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord. Brain Res 273: 170-174
12. Guilarte TR, Block LD, Wagner Jr HN (1988) The putative endogenous convulsant 3-hydroxykynurenine decreases benzodiazepine receptor binding affinity: implications to seizures associated with neonatal vitamin B-6 deficiency. Pharmacol Biochem Behav 30: 665-668
13. Heyes MP, Markey SP (1988) Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical localization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations. Anal Biochem 174: 349-359
14. Heyes MP, Quearry BJ, Markey SP (1989) Systemic endotoxin increases L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex. Brain Res 491: 173-179
15. Heyes MP, Papagapiou M, Leonard C, Markey SP, Auer RN (1990) Brain and plasma quinolinic aid in profound insuline-induced hypoglycemia. J Neurochem 54: 1027-1033
16. Hicks RR, Smith DH, Gennarelli TA, McIntosh T (1994) Kynurenate is neuroprotective following experimental brain injury in the rat. Brain Res 655: 91-96
17. Kessler M, Terramani T, Lynch G, Baudry M (1989) A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists. J Neurochem 52: 1319-1328
18. Lapin IP (1978a) Convulsions and tremor in immature rats after intraperitoneal injection of kynurenine and its metabolites. Pharmacol Res Comm 10: 81-84
19. Lapin IP (1978b) Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice. J Neural Transm 42: 37-43
20. Lapin IP (1981) Kynurenines and seizures. Epilepsia 22: 257-265
21. Lapin IP, Prakhie IB, Kiseleva IP (1982) Excitatory effects of kynurenine and its metabolites, amino acids and convulsants administered into brain ventricles: differences between rats and mice. J Neural Transm 54: 229-238
22. Mehler AH (1956) Formation of picolinic and quinolinic acids following enzymatic oxidation of 3-hydroxyanthranilic acid. J Biol Chem 218: 241-254
23. Mehler AH, May EL (1956) Studies with carboxy-labeled 3-hydroxyanthranilic and picolinic acids in vivo and in vitro. J Biol Chem 223: 449-455
24. Melillo G, Cox GW, Radzioch D, Varesio L (1993) Picolinic acid, a catabolite of L-tryptophan, is a costimulus for the induction of reactive nitrogen intermediate production in murine macrophages. J Immunol 150: 4031-4040
25. Moroni F, Lombardi G, Carl V, Lal S, Etienne P, Nair NPV (1986) Increase in the content of quinolinic acid in cerebrospinal fluid and frontal cortex of patients with hepatic failure. J Neurochem 47: 1667-1671
26. Moroni F, Russi P, Lombardi G, Beni M, Carl V (1988) Presence of kynurenic acid in the mammalian brain. J Neurochem 51: 177-180
27. Nagasawa HT, Gutmann HR (1959) The oxidation of o-aminophenols by cytochrome C and cytochrome oxidase. I. Enzymatic oxidations and binding of oxidation products to bovine serum albumin. J Biol Chem 234: 1593-1599
28. 2+-dependent depolarization and burst firing of rat CA1 pyramidal neurons induced by N-methyl-D-aspartic acid and quinolic acid: antagonism by 2-amino-5-phosphonovaleric and kynurenic acids. Can J Physiol Pharmacol 64: 163-168
29. Perkins MN, Stone TW (1982) An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res 247: 184-187
30. Perkins MN, Stone TW (1983) Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system. J Pharmacol Exp Ther 226: 551-557
31. Perkins MN, Stone TW (1985) Actions of kynurenic acid and quinolic acid in the rat hippocampus in vivo. Exp Neurol 88: 570-579
32. Pinelli A, Ossi C, Colombo R, Tofanetti O, Spazzi L (1984) Experimental convulsions in rats induced by intraventricular administration of kynurenine and structurally related compounds. Neuropharmacology 23: 333-337
33. Schwarcz R, Brush GS, Foster AC, French ED (1984) Seizure activity and lesions after intrahippocampal quinolinic acid injection. Exp Neurol 84: 1-17
34. Speciale C, Schwarcz R (1990) Uptake of kynurenine into rat brain slices. J Neurochem 54: 156-163
35. Stone TW (1993) Neuropharmacology of quinolinic acid and kynurenic acids. Pharmacol Rev 45: 309-379
36. Stone TW, Perkins MN (1981) Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol 72: 411-412
37. Stone TW, Connick JH (1985) Quinolinic acid and other kynurenines in the central nervous system. Neuroscience 15: 597-617
38. Thompson JL, Holmes GL, Taylor GW, Feldman DR (1988) Effects of kynurenic acid on amygdaloid kindling in the rat. Epilepsy Res 2: 302-308
39. Turski WA, Gramsbergen JBP, Traitler H, Schwarcz R (1989) Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine. J Neurochem 52: 1629-1636
40. Vezzani A, Stasi MA, Wu HQ, Castiglioni M, Weckermann B, Samanin R (1989) Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability. Exp Neurol 106: 90-98
41. Wardley-Smith B, Halsey MJ, Hawley D, Joseph MH (1989) The effects of kynurenic acid, quinolinic acid and other metabolites of tryptophan on the development of the high pressure neurological syndrome in the rat. Neuropharmacology 28: 42-47
42. Young SN, Joseph MH, Gauthier S (1983) Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy. J Neural Transm 58: 193-204