A novel quantitative mating assay for the fungal pathogen Cryptococcus neoformans provides insight into signalling pathways responding to nutrients and temperature

Microbiology

Volumn 144, Issue 6, 1998, Pages 1691-1697

  Dong, Hui ^a   Courchesne, William ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Cryptococcus neoformans; Mating; Signalling; Virulence

Indexed keywords

8 BROMO CYCLIC AMP; CYCLIC AMP; VIRULENCE FACTOR;

ARTICLE; CRYPTOCOCCUS NEOFORMANS; MATING; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; TEMPERATURE; VIRULENCE;

FILOBASIDIELLA NEOFORMANS; FUNGI;

EID: 0031781769     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-144-6-1691     Document Type: Article

References (25)

1. Bigay, J., Deterre, P., Pfister, C. & Chabre, M. (1985). Fluoro-aluminates activate transducin-GTP by mimicking the (γ)-phosphate of GTP in its binding site. FEBS Lett 191, 181-185.
2. Blumer, K. J. & Thorner, J. (1991). Receptor G-protein signalling in yeast. Annu Rev Physiol 53, 37-57.
3. Boeke, J. D., LaCroute, F. & Fink, G. R. (1984). A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoroorotic-acid resistance. Mol Gen Genet 197, 345-346.
4. Chuck, S. L. & Sande, M. A. (1989). Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N Engl J Med 321, 794-799.
5. Ellis, D. H. & Pfeiffer, T. J. (1992). The ecology of Cryptococcus neoformans. Eur J Epidemiol 8, 321-325.
6. Kovacs, J. A., Kovacs, A. A., Polis, M. & 12 other authors (1985). Cryptococcosis in the acquired immunodeficiency syndrome. Ann Intern Med 103, 533-538.
7. Kurjan, J. (1993). The pheromone response pathway in Saccharomyces cerevisiae. Annu Rev Genet 27, 147-179.
8. Kwon-Chung, K. J. (1976a). Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia 68, 821-833.
9. Kwon-Chung, K. J. (1976b). A new species of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans B and C serotypes. Mycologia 68, 942-946.
10. Kwon-Chung, K. J. & Bennett, J. E. (1992). Cryptococcosis. In Medical Mycology, pp. 397-446. Edited by L. A. Febiger. Philadelphia: Lea and Febiger.
11. Kwon-Chung, K. J., Edman, J. C. & Wickes, B. L. (1992). Genetic association of mating types and virulence in Cryptococcus neoformans. Infect Immun 60, 602-605.
12. Levitz, S. M. (1991). The ecology of Cryptococcus neoformans and the epidemiology of cryptococcosis. Rev Infect Dis 13, 1163-1169.
13. Marsh, L., Neiman, A. M. & Herskowitz, I. (1991). Signal transduction during pheromone response in yeast. Annu Rev Cell Biol 7, 699-728.
14. Mitchell, T. G. & Perfect, J. R. (1995). Cryptococcosis in the era of AIDS - 100 years after the discovery of Cryptococcus neoformans. Clin Microbiol Rev 8, 515-548.
15. Moore, T. D. E. & Edman, J. C. (1993). The a mating type locus of Cryptococcus neoformans contains a peptide pheromone gene. Mol Cell Biol 13, 1962-1970.
16. Nielsen, O. (1993). Signal transduction during mating and meiosis in S. pombe. Trends Cell Biol 3, 60-65.
17. Rozenbaum, R. & Rios Goncalves, A. J. (1994). Clinical epidemiological study of 171 cases of cryptococcosis. Clin Infect Dis 18, 369-380.
18. Sondek, J., Lambright, D. G., Noel, J. P., Hamm, H. E. & Sigler, P. B. (1994). GTPase mechanism of G-proteins from the 1·7-Å crystal structure of transducin α-GDP-AlF4. Nature 372, 276-279.
19. Sprague, G. F., Jr & Thorner, J. (1992). Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae. In The Molecular and Cellular Biology of the Yeast Saccharomyces, pp. 657-744. Edited by J. R. P. E. W. Jones & J. R. Broach. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
20. Stansell, J. D. (1993). Pulmonary fungal infections in HIV-infected persons. Semin Respir Infect 8, 116-123.
21. Sternweis, P. C. & Gilman, A. G. (1982). Aluminium: a requirement for activation for the regulatory component of adenylate cyclase by fluoride. Proc Natl Acad Sci USA 79, 4888-4891.
22. Sugar, A. M. (1991). Overview: cryptococcosis in the patient with AIDS. Mycopathologia 114, 153-157.
23. Tolkacheva, T., McNamara, P., Piekarz, E. & Courchesne, W. E. (1994). Cloning of a Cryptococcus neoformans gene, GPA1, encoding a G-protein α subunit homolog. Infect Immun 62, 2849-2856.
24. Vaillancourt, L. J. & Raper, C. A. (1996). Pheromones and pheromone receptors as mating-type determinants in basidio-mycetes. Genet Eng 18, 219-247.
25. Zuger, A., Louie, E., Holzman, R. S., Simberkoff, M. S. & Rahal, J. J. (1986). Cryptococcal disease in patients with the acquired immunodeficiency syndrome: diagnostic features and outcome of treatment. Ann Intern Med 104, 234-240.