The growth inhibitory effect of N1,N12-bis(ethyl)spermine in small cell lung cancer cells is maintained in cells expressing the c-myc and Ha- ras oncogenes

Clinical Cancer Research

Volumn 4, Issue 6, 1998, Pages 1557-1561

  Barr, Linda F ^a,b,c   Campbell, Susan E ^a   Tamez, Pamela ^b   Casero Jr , Robert A ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N1,N12 DIETHYLSPERMINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; ONCOGENE C MYC; ONCOGENE H RAS; POLYAMINE METABOLISM; PRIORITY JOURNAL;

ACETYLTRANSFERASES; ANTINEOPLASTIC AGENTS; CARCINOMA, SMALL CELL; CELL DIVISION; GENES, MYC; GENES, RAS; GROWTH INHIBITORS; HUMANS; KINETICS; LUNG NEOPLASMS; ONCOGENE PROTEIN P21(RAS); POLYAMINES; PROTO-ONCOGENE PROTEINS C-MYC; SPERMINE; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0031780130     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Marton, L. J., and Pegg, A. E. Polyamines as targets for therapeutic intervention. Annu. Rev. Pharmacol., 35: 55-91, 1995.
2. Casero, R. A., Celano, P., Ervin, S. J., Porter, C. W., Bergeron, R. J., and Libby, P. R. Differential induction of spermidine/spermine N-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamme analogues. Cancer Res., 49: 3829-3833, 1989.
3. 12-bis(ethyl)spermine in human cell lines representing the major forms of lung cancer. Cancer Res., 52: 5359-5363, 1992.
4. 1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines. Cancer Res., 51: 3715-3720, 1991.
5. Chang, B. K., Bergeron, R. J., Porter, C. W., and Liang, Y. Antitumor effects of N-alkylated polyamine analogues in human pancreatic adenocarcinoma models. Cancer Chemother. Pharmacol., 30: 179-182, 1992.
6. Richardson, G. E., and Johnson, B. E. The biology of lung cancer. Semin. Oncol., 20: 105-127, 1993.
7. Abeloff, M. D., Eggleston, J. C., Mendelsohn, G., Ettinger, D. S., and Baylin, S. B. Changes in morphologic and biochemical characteristics of small cell carcinoma of the lung: a clinicopathologic study. Am. J. Med., 66: 757-764, 1979.
8. Barr, L. F., Campbell, S., Penno, M. B., Ball, D. W., and Baylin, S. B. Cell:substratum interactions mediate oncogene-induced phenotype of lung cancer cells. Cell Growth Differ., 7: 1149-1156, 1996.
9. Mabry, M., Nelkin, B. D., Falco, J. P., Barr, L. F., and Baylin, S. B. Transitions between lung ancer phenotypes: implications for tumor progression. Cancer Cells, 3: 53-58, 1991.
10. Bergeron, R. J., Garlick, J. R., and Stolowich, N. J. Reagents for the stepwise functionalization of spermidine, homospermine, and bis (3-amino-propyl)amine. J. Organic Chem., 49: 2997-3001, 1984.
11. Bergeron, R. J., Neims, A. H., McManis, J., Hawthorne, J. S., Vinson, J. R. T., Bortell, R., and Ingeno, M. J. Synthetic polyamine analogues as antineoplastics. J. Med. Chem., 31: 1183-1190, 1988.
12. Carney, D. N., Gazdar, A. F., Bepler, G., Guccion, J. G., Marangos, P. J., Moody, T. W., Zweig, M. H., and Minna, J. D. Establishment and identification of small cell lung cancer cell lines having classic and variant features. Cancer Res., 45: 2913-2923, 1985.
13. Johnson, B. E., Ihde, D. C., Makuch, R. W., Gazdar, A. F., Carney, D. N., Oie, H., Russell, E., Nau, M. M., and Minna, J. D. myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course. J. Clin. Invest., 79: 1629-1634, 1987.
14. 1-acetyltransferase. Biochem. Biophys. Res. Commun., 179: 407-415, 1991.
15. Kabra, P. M., Lee, H. K., Lubich, W. P., and Marton, L. J. Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reverse phase liquid chromatography: improved separation systems for polyamines in cerebrospinal fluid, urine and tissues. J. Chromatogr. Biomed. Appl., 380: 19-32, 1986.
16. Bradford, C. A. A rapid and sensitive method for quantitation of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254, 1976.
17. Bello-Fernandez, C., Packham, G., and Cleveland, J. L. The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc. Natl. Acad. Sci. USA, 90: 7804-7808, 1993.
18. 12-bis(ethyl)spermine, on polyamine metabolism and cell growth in human melanoma cell lines and melanocytes. Anticancer Res., 12: 1083-1090, 1992.
19. Rodenhuis, S., Slebos, R. J., Boot, A. J., Evers, S. G., Mooi, W. J., Wagenaar, S. S., van Bodegom, P. C., and Bos, J. L. Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res., 48: 5738-5741, 1988.
20. Brennan, J., O'Connor, T., Makuch, R. W., Simmons, A. M., Russell, E., Linnoila, R. I., Phelps, R. M., Gazdar, A. F., Ihde, D. C., and Johnson, B. E. Myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens. Cancer Res., 57: 1708-1712, 1991.
21. Rodenhuis, S., Slebos, R. J., Boot, A. J., Evers, S. G., Mooi, W. J., Wagenaar, S. S., van Bodegom, P. C., and Bos, J. L. Incidence and possible clinical significance of k-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res., 48: 5738-5741, 1988.
22. Rodenhuis, S., van de Wetering, M. L., Wolter, J. M., Evers, S. G., van Zandwijk, N., and Bos, J. L. Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung. N. Engl. J. Med., 317: 929-935, 1987.
23. ras gene products among histological subtypes of fresh primary human lung tumors. Cancer Res., 46: 1530-1534, 1986.
24. Lacal, J. C., Fleming, T. P., Warren, B. S., Blumberg, P. M., and Aaronson, S. A. Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product. Mol. Cell Biol., 7: 4146-4149, 1987.
25. Wolfman, A., and Macara, I. G. Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts. Nature (Lond.), 325: 359-361, 1987.
26. 1 -acetyltransferase induction. Arch. Biochem. Biophys., 268: 209-214, 1989.
27. Bowlin, T. L., McKown, B. J., and Sunkara, P. Ornithine decarboxylase induction and polyamine biosynthesis are required for the growth of interleukin-2- and interleukin-3-dependent cell lines. Cell Immunol., 98: 341-350, 1986.
28. Auvinen, M., Paasinen, A., Anderson, L. C., and Holtta, E. Ornithine decarboxylase activity is critical for cell transformation. Nature (Lond.), 360: 355-358, 1992.
29. Chang, B. K., Libby, P. R., Bergeron, R. J., and Porter, C. W. Modulation of polyamine biosynthesis and transport by oncogene transfection. Biochem. Biophys. Res. Commun., 757: 264-270, 1988.
30. Ha, H. C., Woster, P. M., Yager, J. D., and Casero, R. A., Jr. The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc. Natl. Acad. Sci. USA, 94: 11557-11562. 1997.