Obesity in female life - From molecular to clinical aspects;Adipositas im Leben der Frau - Von molekularen zu klinischen aspekten

Zentralblatt fur Gynakologie

Volumn 120, Issue 5, 1998, Pages 223-234

  Geisthovel F ^a  

^a Gemeinschaftspraxis Freiburg i Br ^*

Author keywords

Aetiological factors; Obesity; Risk factors; Treatment; Women

Indexed keywords

ARTERIOSCLEROSIS; ARTICLE; CHILDHOOD DISEASE; COMORBIDITY; FEMALE; HUMAN; HYPERANDROGENISM; MALIGNANT NEOPLASTIC DISEASE; OBESITY; OVARY POLYCYSTIC DISEASE; POSTMENOPAUSE; REPRODUCTION;

ADOLESCENT; ADULT; AGED; ARTERIOSCLEROSIS; CHILD; COMBINED MODALITY THERAPY; FEMALE; GENE EXPRESSION; HUMANS; INSULIN RESISTANCE; LEPTIN; MIDDLE AGED; NEOPLASMS; OBESITY; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PROTEINS; RISK FACTORS;

EID: 0031779033     PISSN: 00444197     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (93)

1. Allison DB, Paultre F, Heymsfield SB, Pi-Sunyer FX: Is the intra-uterine period really a critical period for the development of adiposity? Int J Obesity Rel Metab Dis 19 (1995) 397-402
2. Amer P: Impact of visceral fat. Int J Obesity 21 (1997) Suppl. 2, 21
3. Astrup A, G(tzsche P, Toubro S, Ranneries C, van der Werken K, Raben A, Buemann B: A low resting metabolic rate in formerly obese: a meta-analysis. Int J Obesity 21 (1997) Suppl. 2, 19
4. Barth JH, O'Kane M, Wales, JK: Nutritional deficiencies in obese patients. Int J Obesity 21 (1997) Suppl. 2, 84
5. Björntorp P: Insulin resistance syndrome & cardiovascular disease. In: Non-insulin dependent diabetes. Ed.: Robertson J. IBC UK Conferences LTD 1996, 1-10
6. Bouchard C: Is weight fluctuation a risk factor? New Eng J Med 324 (1991) 1887-1889
7. Boumediene A, Pecquery R, Dieudonne MN, Leneveu MC, Giudicelle Y: Androgen receptors in human adipocytes and preadipocytes: in vitro effects of androgens and adipocytes. Int J Obesity 21 (1997) Suppl. 2, 8
8. Brandes R, Arad R, Bar-Tana J: Induces of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells. Biochem Pharmacol 50 (1995) 1949-1951
9. Burniat W: Childhood obesity: Which specifities? Int J Obesity 21 (1997) Suppl. 2, 468
10. Castelli WP: The triglyceride issue: A view from Framingham. Am Heart J 112 (1986) 432-437
11. Cioffi JA, Shafer AW, Zupancic TJ, Smith-Gibur J et al. Novel B219/ob receptor isofroms: possible role of leptin in hematopoiesis and reproduction. Nature Med 2 (1996) 585-589
12. Clement K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD: Genetic variation in the beta 3-adrenergic and an increased capacity to gain weight in patients with morbid obesity. New Eng J Med 333 (1995) 352-354
13. Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD, Schaff HV. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med (1997) 581-588
14. Corpas E, Harman SM, Blackman MR: Human growth hormone and human aging. Endocr Rev 14 (1993) 20-39
15. Davidson MB: Effect of growth hormone on carbohydrate and lipid metabolism. Endocr Rev 8 (1987) 115-131
16. Drouin P, Hanotin C, Thomas F, Leutenegger E: Efficiancy and tolerability of sibutramine versus dexfenfluramine in obese patients. Int J Obesity 19 (1995) Suppl. 2, 144
17. Dunaif A, Scott D, Finegood D, Quintana B, Whitcomb R: The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. J Clin Endocrinol Metab 81 (1996) 3299-3306
18. Ehrmann DA, Schneider DJ, Sobel BE, Cavaghan, MK, Imperial J, Rosenfield RL, Polonsky KS: Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 82 (1997) 2108-2116
19. Ennockson S, Shimizu M, Lonnqvist F, Nordenström J, Arner P: Demonstration of an in vivo functional beta 3-adrenoceptor in man. J Clin Invest 95 (1995) 2239-2245
20. Finer N: Weight reduction with orlistat and effects on risk factors: a 1-year UK study. Int J Obesity 21 (1997) Suppl. 2, 31
21. Frayn KN: Nutrient partitioning: is LPL the gatekeeper? Int J Obesity 21 (1997) Suppl. 2, 5
22. Frelut ML: Childhood obesity: from clinics to leptin. Int J Obesity 21 (1997) Suppl. 2, 469
23. Frohman LA, Jansson JO: Growth hormone-releasing hormone. Endocr Rev 7 (1986) 223-253
24. Gauguier D: Mapping genes for NIDDM & obesity ín the Goto-Kakizaki (GK) rat. In: Non-insulin dependent diabetes. Ed.: Robertson J. London: IBC UK Conferences LTD 1996
25. Geisthövel F, Olbrich M, Frorath B, Thiemann M., Weitzell R: Obesity and hypertestosteronemia are independently and synergistically associated with elevated insulin concentrations and dyslipidaemia in pre-menopausal women. Hum Reprod 9 (1994) 610-616
26. Geisthövel F: Ovarfunktionsstörungen bei Adoleszenten und Frauen ohne Kinderwunsch. In: IX. Intensivkurs für Klinische Endokrinologie und Reproduktionsmedizin für Frauenärzte. Fortbildungsveranstaltung der Deutschen Gesellschaft für Endokrinologie. Hrsg.: Leidenberger FA, Schulte HM, Diedrich KD. Hamburg: 1996, 139-153
27. Geisthövel F, Forath B, Brabant G: Acarbose reduces elevated testosterone serum concentrations in hyperinsulinaemic premenopausal women: a pilot study. Hum Reprod 11 (1996) 2377-2381
28. 19-steroids, C-peptide and insulin in serum of obese and non-obese premenopausal women. Hum Reprod (1997) in press
29. Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linmeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weeinshank RL: A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382 (1996) 168-171
30. Goldschmid MG, Barrett-Connor E, Edelstein SL, Wingard DL, Cohn BA, Herman WH: Dyslipidemia and ischemic heart disease mortality among men and women with diabetes. Circulation 89 (1994) 991-997
31. Gortmaker SL, Must A, Perrin JM, Sobol AM, Dietz WH Social and economic consequences of overweight in adolescence and young adulthood. N Eng J Med 329 (1993) 1008-1012
32. 3adrenoceptors. In: Obesity: Recent advances and prospects for therapy. Eds.: IBC UK Conferences, London 1995
33. Hazzard WR: Why women live longer than men (or why can't a man be more like a woman?). In: Hormones in lipoprotein metabolism. Eds.: Steinmetz A, Schneider J, Kaffarnik H. Berlin - Heidelberg - New York: Springer 1993, 89-97
34. Heymsfield Sb, Gallagher D, Poehlman ET, Wolper C, Nonas K, Nelson D, Wang ZM: Menopausal changes in body composition and energy expenditure. Experim Gerontology 29 (1994) 377-389
35. Hirsch J, Leibel R: Clinical review 28: A biological basis for human obesity. J Clin Endcrinol Metab 73 (1991) 1153-1157
36. Hubert HB, Feinleib M, MacNamara PM, Kannel WB, Dawber TR: High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Circulation 67 (1983) 989-977
37. Iranmanesh A, Lizzarralde G, Veldhuis JD: Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory burst and half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 73 (1991) 1081-1088
38. Kannel WB: Metabolic risk factors for coronary heart disease in women: perspective from the Framingham study. Am Heart J 114 (1987) 413-419
39. Karhapä̈ P, Malkki, M, Laakso, M: Isolated low HDL cholesterol. Diabetes 43 (1994) 411-417
40. Kelly F, Wade AG, Jones SP, Johnson SG: Sibutramine hydrochloride vs dexfenfluramine: weight loss in obese subjects. Int J Obesity 18 (1995) Suppl. 2, 144
41. Kissebah AH, Vydelingum N, Murray R., Evans DJ, Hartz AJ, Kalkhoff RK, Adams PW: Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 54 (1982) 524-560
42. Kissebah A, Peiris A: Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus. Diabetes Metab Rev 5 (1989) 83-109
43. Knittle JL, Timmers K, Ginsberg-Fellner F, Brown RE, Katz DP: The growth of adipose tissue in children and adolescents. J Clin Invest 63 (1979) 239-246
44. Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U: Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest 72 (1983) 1150-1162
45. Langin D, Tavernier G, Lafontan M: Regulation of beta 3-adrenoreceptor expression in white fat cells. Fund Clin Pharmacol 9 (1995) 97-106
46. Lehmann J, Moore L, Smith-Oliver T, Wilkinson W, Wilson T, Kliewer S: An antidiabeteic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor (PPAR). J Biol Chem 270 (1995) 12953-12956
47. Ley CJ, Bees B, Stevenson JC: Sex- and menopause-associated changes in body-fat distribution. Am J Clin Nutr 55 (1992) 950-954
48. Lissau I: Psycho-social developments in clinical management of obesity. Symposium Psycho-social developments in obesity. Int J Obesity 12 (1997) Suppl. 2, 23
49. [48a] Löffler G: Pathophysiologie des Fettgewebes. Deutsches Ärzteblatt 94 (1997) A2003-A2006
50. Mark EJ, Patalas ED, Chang HT, Evans RJ, Kessler SC. Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine. N Engl J Med 337 (1997) 602-606
51. Markussis V, Beshyah SH, Fischer C, Sharp P, Nocolaides AN, Johnston DG: Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypo pituitary adults. Lancet 340 (1992) 1188-1192
52. Mazariegos M, Wang ZM, Gallagher D, Baumgartner RN, Allison DB, Wang J, Pierson RN Jr, Heymsfield SB: Differences between young and old females in the five levels of body composition and their relevances to the two-compartment chemical model. J Gerontology 49 (1994) 201-208
53. Mikkelsen PB, Vedelspang A, Hansen DL, Toubro S, Astrup A: Risk factors for dropping out in a weight loss programme. Int J Obesity 21 (1997) Suppl. 2, 115
54. Mosberg HO: 40 years follow-up of overweight children. i. Lancet (1989) 491-493
55. Must A: Long term morbidity and mortality in overweight adolescents. A follow-up ot the Harvard growth study of 1992 to 1935. Lancet 327 (1992) 1350-1355
56. National Center for Health Statistics. Anthropometric reference data and revalence of overweight: United States, 1976-80. Vital and health statistics. Series 11, No 238, Washington D.C.: Government Printing Office, 1987 (DHHS publication no. (PHS) 87-1688)
57. Nolan J, Ludvik B, Beerdsen P, Joyce M, Olefsky J: Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med 331 (1994) 1188-1193
58. Ostlund RE, Staten M, Kohrt WM, Schultz J, Malley M: The ratio of waist-to-hip circumference, plasma insulin level, and glucose intolerance as independent predictors of the HDL2 cholesterol level in older adults. N Engl J Med 322 (1990) 229-234
59. Pyka G, Wiswell RA, Marcus R: Age-dependent effect of resistance exercise on growth hormone secretion in people. J Clin Endocrinol Metab 75 (1992) 404-407
60. Raymond DE, Hoffmann RG, Kalkhoff RK, Kissebah A: Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopasual women. J Clin Endocrinol Metab 57 (1983) 304-310
61. Rasmussen MH, Frystyk J, Andersen T, Breum L, Christiansen JS, Hilsted J: The impact of obesity, fat distribution, and energy restriction on insulin-like growth factors 1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone. Metabolism 43 (1994) 325-319
62. Ricquier D: Hot topic lecture: from the brown fat uncoupling protein 1 to the widely expressed UCP2, and other UCPs. Int J Obesity 12 (1997) Suppl. 2. 3
63. [61a] Riedel M, Brabant G, Rieger K, von zur Mühlen A: Growth hormone therapy in adults: rationales, results, and perspectives. Exp Clin Endocrinol 102 (1994) 273-283
64. Rodin J, Radke-Sharpe N, Rebuffe-Scrive M, Greenwood MR: Weight cycling and fat distribution. Int J Obesity 14 (1990) 303-310
65. Rosen T, Bengtsson BA: Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336 (1990) 286-288
66. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL: Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81 (1996) 3424-3427
67. Rosenbaum M, Leibel RL, Hirsch J: Obesity. N Engl J Med 337 (1997) 398-407
68. Ross RJM, Buchanan CR: Growth hormone secretion: its regulation and the influence of nutritional factors. Nutrition Res Rev 3 (1990) 143-162
69. Ryan DH: Sibutramine. Obesity research 3 (1995) Suppl. 3, 317
70. Sachse G: Differentialtherapie mit oralen Antidiabetika. In: Intensivkurs für Klinische Endokrinologie. Hrsg.: Allolio B, Grußendorf M, Müller OA, Olbricht T, Schulte HM. Neu-Isenburg: Bundesdruckerei 1995, 216-219
71. Saltiel A, Olefsky J: Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 45 (1996) 1661-1669
72. Sandage BW: Summary of Dexfenfluramine. In: Obesity: Recent advances and prospects for therapy. Eds.: IBC UK Conferences. London 1995
73. Saris WHM: Is the ability to modify macronutrient selection and oxidation in humans an achievable and desirable target? In: Obesity treatments: recent advances in understanding and treatment. Eds.: IBC UK Conferences. London 1996
74. Schwandt P, Krause J, Krümke W, Heath M: Sibutramine in the treatment of obese patients with metabolic syndrome. Int J Obesity 21 (1997) Suppl. 2, 56
75. 3-adrenoceptor. In: Obesity: Recent advances in understanding and treatment. Eds.: IBC UK Conferences. London 1996
76. Stryer L: Biochemie. Heidelberg - Berlin - Oxford: Spektrum Akadem Verlag 1994
77. Stubbs RJ: Macronutrient effects on appetite. Int J Obesity 19 (1995) Suppl. 5, 11-19
78. Stunkard AJ, Harris JR, Pedersen NL McClearn GE: The body-mass index of twins who have been reared apart. New Eng J Med 322 (1990) 1483-1487
79. Swinburn B, Ravussin E: Energy balance or fat balance? Am J Clin Nutr 57 (1993) 766S-771S
80. Toeller M: Modulation of intestinal glucose absorption: postponement of glucose absoption by alpha-glucosidase inhibitors. In: Pharmacology of Diabetes. Eds: Mogensen CE, Standl E. Berlin - New York: Walter de Gruyter 1991
81. Toplak H, Bahadori B: A 6-month dose-ranging study of orlistat in the treatment of obesity. Int J Obesity 21 (1997) Suppl 2, 51
82. Tremblay A, Simoneau JA, Rouchard C: Impact of exercise intensity on body fatness and skeletal muscle matabolism. Metabolism 43 (1994) 814-818
83. Uhl H, Wurmser H, Laessle R, Pirke KM: Resting metabolic rate and endocrine findings in female obese children and adolescents. Int J Obesity 21 (1997) Suppl. 2, 27
84. Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S, Manning B, Strosberg AD, Stern MP, Raben N et al: Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. New Eng J Med 333 (1995) 343-347
85. Wechsler JG: Diätetische Therapie der Adipositas. Deutsches Ärzteblatt 94 (1997) A2250-A2256
86. Weck M, Matthies K: Autonomic nervous system activity and body fat distribution in premenopausal obese women. Int J Obesity 21 (1997) Suppl. 2, 76
87. Widen E, Lehto M, Kanninen T, Walston J, Shuldiner AR: Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. New Eng J Med 333 (1995) 348-351
88. Williams G: Neuropeptides in the regulation of energy balance. In: Obesity: Recent advances and prospects for therapy. Eds.: IBC UK Conferences. London 1995
89. Wing RR, Matthews KA, Kuller LH, Meilahn EN, Plantinga PL: Weight gain at the time of menopause. Arch Intern Med 151 (1991) 97-102
90. Wüster C, von zur Mühlen A, Ranke MB: Das Syndrom des Wachstumshormonmangels beim Erwachsenen. Therapiebedürftige Erkrankung oder altersphysiologische Veränderung? Deutsches Ärzteblatt 91 (1994) A2402-A2408
91. Zachow RJ, Magoffin DA: Direct intraovarain effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17( production by rat ovarian granulosa cells. Endocrinology 138 (1997) 847-850
92. Zhang Y, Proenca R, Maffei M, Barone M: Positional cloning ot the mouse obese gene and it's human homologue. Nature 372 (1994) 425-432
93. Zhi J, Pace D, Guerciolini R: Clinical pharmacokinetics and disposition of orlistat, a novel weight reduction agent. Int J Obesity 21 (1997) Suppl 2, 51