Indium-111 DTPA-heparin: Radiolabeling, pharmacokinetics, and biodistribution following intravenous administration in rat and rabbit

Thrombosis Research

Volumn 89, Issue 1, 1998, Pages 23-30

  Bunting, Robert W ^a   Wilkinson, Robert A ^b   Callahan, Ronald J ^b   Strauss, H W ^c   Fischman, Alan J ^b  

^a and Red Sox Foundation and Massachusetts General Hospital Home Base Program   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Biodistribution; Heparin; Intravenous; Pharmacokinetics

Indexed keywords

HEPARIN; PENTETATE INDIUM IN 111; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; CHELATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFECT; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RABBIT; RADIOCHROMATOGRAPHY; RAT;

ANIMALS; ANTICOAGULANTS; HALF-LIFE; HEPARIN; INJECTIONS, INTRAVENOUS; METABOLIC CLEARANCE RATE; PENTETIC ACID; PRECIPITATION; PROTAMINES; RABBITS; RADIOPHARMACEUTICALS; RATS; TISSUE DISTRIBUTION;

EID: 0031778164     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(97)00279-X     Document Type: Article

References (20)

1. 1. Hirsh J. Heparin. NEJM 1991;324:1565-74.
2. 2. Kulkarni PV, Parkey RW, Buja LM, Wilson JE III, Bonte FJ, Willerson JT. Technetium-labeled heparin: Preliminary report of a new radiopharmaceutical with potential for imaging damaged coronary arteries and myocardium. J Nucl Med 1978;19:810-5.
3. 3. Kulkarni PV, Parkey RW, Wilson JE III, Lewis SE, Buja LM, Bonte FJ, Willerson JT. Modified technetium-99m heparin for the imaging of acute experimental myocardial infarcts. J Nucl Med 1980;21:117-21.
4. 4. Laforest MD, Colas-Linhart N, Guiraud-Vitaux F, Bok B, Bara L, Samama M, Marin J, Imbault F, Uzan A. Pharmacokinetics and biodistribution of technetium 99m labelled standard heparin and a low molecular weight heparin (enoxaparin) after intravenous injection in normal volunteers. Br J Haem 1991; 77:201-8.
5. 5. Sugisaka N, Petracek FJ. Rapid molecular size characterization of heparins by high pressure liquid chromatography. Fed Proc 1997;36:89-92.
6. 6. Eiber HB, Danishefsky I, Borrelli FJ. Physiological disposition of heparin. Proc Soc Exp Biol Med 1958;98:672-4.
7. 7. Day M, Green JP, Robinson JD Jr. Disposition of (35S)-heparin in the rat. Br J Pharmacol 1962;18:625-9.
8. 8. Barlow GH, Cardinal EV. Preparation and characterization of tritiated heparin. Proc Soc Exp Biol Med 1966;123:831-2.
9. 9. Dawes J, Pepper DS. Catabolism of low-dose heparin in man. Thromb Res 1979;14:845-60.
10. 10. Krejcarek GE, Tucker KL. Covalent attachment of chelating groups to macromolecules, Biochem Biophys Res Commun 1977;77:581-5.
11. 11. Schwarz SW, Mathias CJ, Sun JY, Dilley WG, Wells SA Jr, Martell AE, Welch MJ. Evaluation of two new bifunctional chelates for radiolabeling a parathyroid-specific monoclonal antibody with In-111. Nuc Med Biol 1991; 18(5):477-81.
12. 12. Welch MJ, Welch TJ. Solution chemistry of carrier-free Indium. In: Subramanian G, Rhodes B, Cooper JF, Sodd VJ, editors. Radiopharmaceuticals. New York: Society of Nuclear Medicine Publications; 1975.
13. 13. De Swart CAM, Nijmeyer B, Roelofs JMM, Sixma JJ. Kinetics of intravenously administered heparin in normal humans. Blood 1982; 60:1251-8.
14. 14. Shanberge JN, Gruhl M, Kitani T, Ambegaonkar S, Kambayashi J, Nakagawa M, Lenter D. Fractionated tritium-labelled heparin studied in vitro and in vivo. Thromb Res 1978;13:767-83.
15. 15. Alant O, Varga L, Antoni F, Karacsonyi S, Faller J. Metabolism and anticoagulant effect of 51Cr-labelled heparin. Acta Physiologica Academiae Scientiarum Hungaricae 1973;43: 261-7.
16. 16. Ginsberg JS, Kowalchuk G, Hirsh J, Brill-Edwards P, Burrows R, Coates G, Webber C. Heparin effect on bone density. Thromb Haemost 1990;64(2):286-9.
17. 17. Boneu B, Caranobe C, Sie P. Pharmacokinetics of heparin and low molecular weight heparin. Balliere's Clinical Haematology 1990;3:531-44.
18. 18. Boneu B, Dol F, Caranobe C, Sie P, Houin G. Pharmacokinetics of heparin and related polysaccharides. Ann NY Acad Sci 1989;556: 282-91.
19. 19. Shanberge JN, Murato M, Quattrociocchi-Longe T, Van Neste L. Heparin-protamine complexes in the production of heparin rebound and other complications of extracorporeal bypass procedures. Am J Clin Pathol 1987;87:210-7.
20. 20. Montalescot G, Fischman AJ, Strauss HW, Wilkinson RA, Ahmad M, Fitzgibbon C, Robinson DW, Zapol WM. Imaging the ovine heparin-protamine interaction with 111In-protamine. J Appl Physiol 1993;75(2):963-71.