Degradation of urokinase plasminogen activator (UPA) in endometrial stromal cells requires both the upa receptor and the low-density lipoprotein receptor-related protein/α2-macroglobulin receptor

Molecular Human Reproduction

Volumn 4, Issue 6, 1998, Pages 585-593

  Casslén, Bertil ^a   Gustavsson, Barbro ^a   Angelin, Bo ^b   Gåfvels, Mats ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Internalization; LDL receptor related protein; Plasminogen activator inhibitor 1; Receptor associated protein; VLDL receptor

Indexed keywords

ALPHA 2 MACROGLOBULIN; CHLOROQUINE; COLCHICINE; GLYCOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; LYSOSOME ENZYME; MESSENGER RNA; METHYLAMINE; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTOR ANTIBODY; RECEPTOR PROTEIN; UROKINASE; UROKINASE RECEPTOR;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENDOMETRIUM; FEMALE; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; STROMA CELL;

ADULT; CELLS, CULTURED; ENDOCYTOSIS; ENDOMETRIUM; FEMALE; HEYMANN NEPHRITIS ANTIGENIC COMPLEX; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; STROMAL CELLS; URINARY PLASMINOGEN ACTIVATOR;

EID: 0031778133     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/4.6.585     Document Type: Article

References (51)

1. Argraves, K.M., Battey, F.D., MacCalman, C.D. et al. (1995) The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type 1 complexes. J. Biol. Chem., 270, 26550-26557.
2. Battey, F.D., Gåfvels M.E., FitzGerald, D.J. et al. (1994) The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. J. Biol. Chem., 269, 23268-23273.
3. Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
4. Casslén, B , Andersson, A., Nilsson, I.M. et al. (1986) Hormonal regulation of the release of plasminogen activators and of a specific activator inhibitor from endometrial tissue in culture. Proc Soc. Exp. Biol. Med., 182, 419-424.
5. Casslén, B. and Gustavsson, B. (1991) Expression of cell membrane receptors for urokinase plasminogen activator (uPA) in the human endometrium increases during the ovarian cycle. Fibrinolysis, 5, 243-248.
6. Casslén, B., Nordengren, J., Gustavsson, B. et al. (1995) Progesterone stimulates degradation of urokinase plasminogen activator (u-PA) in endometrial stromal cells by increasing its inhibitor (PAI-1) and surface expression of the u-PA receptor. J. Clin. Endocrinol. Metab., 80, 2776-2784.
7. Casslén, B., Siler-Khodr, T. and Harper, M J K. (1990) Progesterone regulation of prolactin release from human endometrial stromal cells in culture: Potential bioassay for progestational activity. Acta Endocrinol., 122, 137-144.
8. Casslén, B., Thorell, J. and Åstedt, B. (1981) Effect of IUD on urokinase-like immunoreactivity and plasminogen activators in human uterine fluid. Contraception, 23, 435-446.
9. Casslén, B., Urano, S., Lecander, I. et al. (1992a) Plasminogen activators in the human endometrium, cellular origin and hormonal regulation. Blood Coag. Fibrinolys, 3, 133-138.
10. Casslén, B., Urano, S. and Ny, T. (1992b) Progesterone regulation of plasminogen activator inhibitor 1 (PAI-1) antigen and mRNA levels in human endometrial stromal cells. Thromb. Res. 66, 75-87.
11. Casslén, B. and Åstedt, B. (1981) Fibrinolytic activity of human uterine fluid. Acta Obstet. Gynecol Scand., 60, 55-58.
12. Casslén, B. and Åstedt, B. (1983) Occurrence of both urokinase and tissue plasminogen activator in the human endometrium. Contraception, 28, 553-564.
13. Coukos, G., Gåfvels, M.E. Wisel, S. et al. (1994) Expression of α2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kDa receptor-associated protein in human trophoblasts. Am. J. Pathol., 144, 383-392.
14. Cubellis, M., Andreasen, P., Ragno, P. et al. (1989) Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor. Proc. Natl. Acad Sci. USA, 86, 4828-4832.
15. Cubellis, M.V., Wun, T.C. and Blasi, F. (1990) Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1. EMBO J., 9, 1079-1085.
16. Danø, K., Behrendt, N., Brünner, N. et al. (1994) The urokinase receptor. Protein structure and role in plasminogen activation and cancer invasion. Fibrinolysis, 8, 189-203.
17. Dumler, I., Petri, T. and Schleuning, W.D. (1993) Interaction of urokinase-type plasminogen activator (u-PA) with its cellular receptor (u-PAR) induces phosphorylation on tyrosine of a 38 kDa protein. FEBS Lett., 322, 37-40.
18. Dumler, I , Petri, T. and Schleuning, W.D. (1994) Induction of C-Fos gene expression by urokinase-type plasminogen activator in human ovarian cancer cells. FEBS Lett., 343, 103-106.
19. Estreicher, A., Mühlhauser, J., Carpentier, J.L. et al. (1990) The receptor for urokinase-type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J. Cell. Biol. 111, 783-792.
20. Feinberg, A P. and Vogelstein, B. (1984) A technique for radiolabelling DNA restriction fragments to high specific activity. Anal. Biochem., 137, 266-267.
21. Gåfvels, M.E., Caird, M., Britt, D. et al. (1993) Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23. Som. Cell. Molecul. Gen., 19, 557-569.
22. Gåfvels, M.E., Coukos, G. Sayegh, R. et al. (1992) Regulated expression of the trophoblast α2-macroglobulin receptor/low density lipoprotein receptor-related protein. J. Biol. Chem., 267, 21230-21234.
23. Heegaard, C.W., Wiborg Simonsen, A.-C., Oka, K. et al. (1995) Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator-type-1 plasminogen activator inhibitor complex. J. Biol. Chem., 270, 20855-20861.
24. Herz, J., Clouthier, D.E. and Hammer, R.E. (1992) LDL receptor-related protein internalizes and degrades u-PA-PAI-1 complexes and is essential for embryo implantation. Cell, 71, 411-421.
25. Jensen, P. H., Christensen, E.I., Ebbesen, P. et al (1990) Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells. Cell. Reg., 1, 1043-1056.
26. Kounnas, M.Z., Argraves, W.S and Strickland, D.K. (1992) The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, a2-macrogiobulin receptor and glycoprotein 330 J. Biol. Chem., 267, 21162-21166.
27. Kounnas, M.Z., Henkin, J., Argraves, W.S. et al. (1993) Low density lipoprotein receptor-related protein/α2-macroglobulm receptor mediates cellular uptake of pro-urokinase. J Biol. Chem., 268, 21862-21867.
28. Loskutoff, D. (1991) Regulation of PAI-1 gene expression. Fibrinolysis, 5, 197-206.
29. Moestrup, S.K., Holtet, T.L., Etzerodt, M. et al. (1993a) α2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the α2-macroglobulin receptor containing a cluster of eight complement-type repeats J. Biol. Chem., 268, 13691-13696.
30. Moestrup, S K., Nielsen, S., Andreasen, P. et al. (1993b) Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes. J. Biol. Chem., 268, 16564-16570.
31. Multhaupt, H.A B., Gafvels, M.E., Kariko, K. et al. (1996) Expression of very low density lipoprotein receptor in the vascular wall: Analysis of human tissues by in situ hybridization and immunohistochemistry. Am. J. Pathol., 148, 1985-1997.
32. Nusrat, A.R. and Chapman, H.A. Jr. (1991) An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines. J. Clin. Invest., 87, 1091-1097.
33. Nykjaer, A., Petersen, C.M., Möller, B. et al. (1992) Purified α2-macroglobulin receptor/LDL receptor-related protein binds urokinase plasminogen activator inhibitor type-1 complex. J. Biol. Chem., 267, 14543-14546.
34. Odekon, L.E., Sato, Y. and Rifkin, D.B. (1992) Urokinase-type plasminogen activator mediates basic fibroblast growth factor-induced bovine endothelial cell migration independent of its proteolytic activity. J. Cell. Physiol., 150, 258-263.
35. Olson, D., Pöllänen, J., Høyer-Hansen, G. et al. (1992) Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor. J. Biol. Chem., 267, 9129-9133.
36. Rabbani, S.A., Desjardins, J and Bell, A.W. (1990) An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells. Biochem. Biophys. Res. Commun., 173, 1058-1064.
37. Ragnö, P., Montuori, N., Vassalli, J.D. et al. (1993) Processing of complex between urokinase and its type-2 inhibitor on the cell surface - A possible regulatory mechanism of urokinase activity. FEBS Lett., 323, 279-284.
38. Roldan, A.L., Cubellis, M.V., Masucci, M.T. et al. (1990) Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J., 9, 467-474.
39. 2-terminal domain of the urokinase receptor. FEBS Lett., 288, 233-236.
40. Sakai, J., Hoshino, A., Takahashi, S. et al. (1994) Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. J. Biol. Chem., 269, 2173-2182.
41. Sandberg, T., Eriksson, P., Gustavsson, B. et al. (1997a) Differential regulation of the plasminogen activator inhibitor-1 (PAI-1) gene expression by growth factors and progesterone in human endometrial stromal cells. Mol Hum. Reprod., 3, 781-787.
42. 1); a possible mechanism for paracrine stimulation of endometrial angiogenesis. Biol. Reprod., in press.
43. Sillem, M., Prifti, S., Monga, B. et al. (1997) Soluble urokinase-type plasminogen activator receptor is over-expressed in uterine endometrium from women with endometriosis. Mol. Hum Reprod., 3, 1101-1105.
44. Stefansson, S., Chapell, D.A., Argraves, K.M. et al. (1995) Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoprotein via interaction with apolipoprotein B100. J. Biol. Chem., 270, 19417-19421.
45. Stephens, R.W., Aumailley, M., Timpl, R. et al. (1992a) Urokinase binding to laminin-nidogen. Structural requirements and interactions with heparin. Eur. J. Biochem., 207, 937-942.
46. Stephens, R.W, Bokman, A.M., Myöhänen, H.T. et al. (1992b) Heparin binding to the urokinase kringle domain. Biochemistry, 31, 7572-7579.
47. Strickland, D K., Kounnas, M.Z., Williams, S.E. et al. (1994) LDL receptor-related protein (LRP): a multiligand receptor. Fibrinolysis, 8, 204-215.
48. Thomas, P.S. (1980) Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci USA, 77, 5201-5205.
49. 125I to high specific activity. Biochim. Biophys. Acta, 251, 363-369.
50. Waltz, D.A., Sailor, L.Z. and Chapman, H.A. (1993) Cytokines induce urokinase-dependent adhesion of human rayeloid cells. A regulatory role for plasminogen activator inhibitors. J. Clin. Invest., 91, 1541-1552.
51. Willnow, T.E., Rohlmann, A., Horton, J. et al. (1996) RAP, a specialized chaperone, prevents ligand induced ER retention and degradation of LDL receptor-related endocytic receptors. EMBO J., 15, 2632-2639.