Elevated density and plasticity of nerve fibres in anal fissures

International Journal of Colorectal Disease

Volumn 13, Issue 3, 1998, Pages 134-140

  Horsch D ^a   Kirsch, J J ^b   Weihe, E ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b Clinic   (Germany)

Author keywords

Anal fissures; Chronic inflammation; Growth associated protein 43; Neural plasticity; Pain; Protein gene product 9.5; Pruritus

Indexed keywords

GENE PRODUCT; NEUROMODULIN;

ADULT; ANUS FISSURE; ANUS PRURITUS; ARTICLE; CELL DENSITY; CELL PROLIFERATION; CHRONIC PAIN; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTESTINE INNERVATION; MALE; NERVE CELL PLASTICITY; NERVE FIBER; PRIORITY JOURNAL; TISSUE SECTION;

CHRONIC DISEASE; FEMALE; FISSURE IN ANO; GAP-43 PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NERVE FIBERS; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; THIOLESTER HYDROLASES; UBIQUITIN THIOLESTERASE;

EID: 0031777778     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003840050151     Document Type: Article

References (42)

1. Fenger C (1992) Anal canal. In: Sternberger S (ed) Histology for pathologists. Raven, New York, pp 607-623
2. Hörsch D, Fink T, Büchler M, Weihe E (1993) Regional specificities in the distribution, chemical phenotypes, and coexistence patterns of neuropeptide containing nerve fibres in the human anal canal. J Comp Neurol 335:381-401
3. Duthie HL, Gairns FW (1960) Sensory nerve-endings and sensation in the anal region of man. Br J Surg 206:585-595
4. Horsch D, Fink T, Göke B, Arnold R, Büchler M, Weihe E (1994) Distribution and chemical phenotypes of neuroendocrine cells in the human anal canal. Regul Pept 54:527-542
5. Christiansen J, Lorentzen M, Holst J (1990) Influence of peptides on anorectal function. Ann Med 22:413-418
6. Brühl W (1982) Ätiologie und Therapie der Analfissur. Coloproctology 2:114-115
7. Kirsch JJ (1989) Out-patient treatment of haemorrhoids - risks and benefits. Results from 16,349 patients. Akt Chir 24:253-259
8. Brown AC, Sumfest JM, Rozwadowski JV (1989) Histopathology of the internal anal sphincter in chronic anal fissure. Dis Colon Rectum 32:680-683
9. Reinhard F, Kirsch JJ (1993) Improved results in the treatment of anal fissures by combined conservative and surgical therapy. Coloproctology 6:370-373
10. Vogel P, Klosterhalfen B (1988) Die chirurgische Anatomie der Rectum- und Analgefäße. Langenbecks Arch Chir 373:264-269
11. Schouten WR, Briel JW, Auwerda JJA (1994) Relationship between anal pressure and anodermal blood flow: the vascular pathogenesis of anal fissures. Dis Colon Rectum 37:664-669
12. Fenger C, Schrøder HD (1990) Neuronal hyperplasia in the anal canal. Histopathology 16:481-485
13. Weihe E, Büchler M, Müller S, Friess H, Zentel HJ, Yanaihara N (1990) Peptidergic innervation in chronic pancreatitis. In: Berger HG, Ditschuneit H, Malfertheimer P (eds) Chronic pancreatitis. Springer, Berlin Heidelberg New York, pp 83-105
14. Weihe E, Hartschuh W (1988) Multiple peptides in cutaneous nerves: regulators under physiological conditions and a pathogenic role in skin disease? Semin Dermatol 7:284-300
15. Büchler M, Weihe E, Friess H, Malfertheimer P, Bockmann DE, Müller S, Nohr D, Beger HG (1992) Changes in peptidergic innervation in chronic pancreatitis. Pancreas 7:183-192
16. Weihe E, Nohr D, Michel S: Müller S, Zentel H-J, Fink T, Krekel J (1991) Molecular anatomy of the neuro-immune connection. Int J Neurosci 59:1-23
17. Abadia Molina F, Burrows NP, Russell Jones R, Terenghi T, Polak JM (1992) Increased sensory neuropeptides in nodular prurigo, aquantitative immunohistochemical analysis. Br J Dermatol 127:344-351
18. Di Sebastiano P, Fink T, Friess H, Weihe E, Beger HG, Büchler M (1995) Changes of protein gene product 9.5 (PGP 9.5) immunoreactive nerves in the inflamed appendix. Dig Dis Sci 40:366-372
19. Fink T, Di Sebastiano P, Büchler M, Beger HG, Weihe E (1994) Growth-associated protein-43 and protein gene-product 9.5 innervation in human pancreas: changes in chronic pancreatitis. Neuroscience 63:249-266
20. Stead RH, Kosecka-Janiszewska U, Oestreicher AB, Dixon MF, Bienenstock J (1991) Remodeling of B-50 (GAP-43)- and NSE-immunoreactive mucosal nerves in the intestines of rats infected with nippostrongylus brasiliensis. J Neurosci 11:3809-3821
21. Horsch D, Weihe E (1994) Profuse peptidergic innervation of the anal canal: a pathogenic factor for anorectal diseases? Gut 35 [Suppl 4]: A 12 (abstract)
22. Sharkey KA, Coggins PJ, Tetztlaff W, Zwiers H, Bisby MA, Davison JS (1990) Distribution of growth-associated protein B-50, (GAP-43), in the mammalian enteric nervous system. Neuroscience 38:13-20
23. Fantini F, Johansson O (1992) Expression of growth associated protein 43 and nerve growth factor receptor in human skin: a comparative immunohistochemical investigation. J Invest Dermatol 99:734-742
24. Gispen WH, Nielander HB, De Graan PNE, Oestreicher AB, Schrama LH, Schotman P (1991) Role of the growth associated protein B-50 (GAP-43) in neuronal plasticity. Mol Neurobiol 5:61-85
25. Jacobsen DJ, Virag I, Skene JHP (1986) A protein associated with axon growth, GAP-43, is widely distributed and developmentally regulated in the rat CNS. J Neurosci 6:1843-1855
26. Oestreicher AB, Dekker LV, Gispen WH (1986) A radioimmunoassay for the phosphoprotein B-50: distribution in rat brain. J Neurochem 46:1366-1369
27. Basi GS, Jacobson RD, Virag I, Schilling J, Skene JHP (1987) Primary structure and transcriptional regulation of GAP-43, a protein associated with cell growth. Cell 49:785-791
28. Benowitz LI, Routtenberg A (1987) A membrane phosphoprotein associated with neural development, axonal regeneration, phospholipid metabolism and synaptic plasticity. Trends Neurosci 10:527-532
29. Skene JHP (1989) Axonal growth associated proteins. Annu Rev Neurosci 12:127-156
30. Chong MS, Fitzgerald M, Winter J, Hu-Tsai M, Emson PC, Wiese U, Woolf CJ (1992) GAP-43 mRNA in rat spinal cord and dorsal root ganglia neurons: developmental changes and reexpression following peripheral nerve injury. Eur J Neurosci 4:883-895
31. MehtaA, Reynolds ML, Woolf CJ (1993) Partial denervation of the medial gastrocnemius muscle results in growth-associated protein-43 immunoreactivity in sprouting axons and Schwann cells. Neuroscience 57:433-442
32. Mearow KM, Kril Y, Gloster A, Diamond J (1994) Expression of NGF receptor and GAP-43 mRNA in DRG neurons during collateral sprouting and regeneration of dorsal cutaneous nerves. J Neurobiol 25:127-142
33. Dekker LV, De Graan PNE, Oestreicher AB, Versteeg DHG, Gispen WH (1989) Inhibition of noradrenaline release by antibodies to B-50 (GAP-43). Nature 342:74-76
34. 2+-induced neuropeptide cholecystokinin-8 release from permeated synaptosomes. J Neurochem 61:602-609
35. Carlton SM, Dougherty PM, Pover CM, Coggeshall RE (1991) Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy. Neurosci Lett 131: 88-92
36. Devor M (1984) The pathophysiology and anatomy of damaged nerve. In: Wall PD, Melzack R (eds) Textbook of pain. Churchill Livingstone, New York, pp 49-64
37. Winkelmann RK (1988) Pruritus. Semin Dermatol 7:233-235
38. Di Sebastiano P, Fink T, Weihe E, Friess H, Innocenti P, Beger HG, Büchler W (1997) Immune cell infiltration and growth-associated protein 43 expression correlate with pain in chronic pancreatitis. Gastroenterology 112:1648-1655
39. Jost WH, Schimrigk K (1994) Therapy of anal fissure using botulinium toxin. Dis Colon Rectum 37:1321-1324
40. Lund JN, Scholefield JH (1997) Glyceryl trinitrate is an effective treatment for anal fissure. Dis Colon Rectum 40:468-470
41. Jansco G, Lynn B (1987) Possible role of capsaicin in pain therapy. Clin J Pain 3:123-126
42. Maggi CA (1991) Capsaicin and primary afferent neurons: from basic science to human therapy. J Auton Nerv Syst 33:1-14