Double-blind, placebo-controlled study on effects of diclofenac sodium and indomethacin on postprandial gastric motility in man

Digestive Diseases and Sciences

Volumn 43, Issue 6, 1998, Pages 1172-1176

  Bassotti, Gabrio ^a   Bucaneve, Giampaolo ^b   Furno, Paolo ^b   Morelli, Antonio ^b   Del Favero, Albano ^b  

^a POLICLINICO MONTELUCE   (Italy)

^b NONE

Author keywords

Diclofenac; Gastric motility; Indomethacin; Manometry

Indexed keywords

DICLOFENAC; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; EPIGASTRIC PAIN; FEMALE; HEADACHE; HEARTBURN; HUMAN; HUMAN EXPERIMENT; MALE; MANOMETRY; NAUSEA; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; POSTPRANDIAL STATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH ANTRUM; STOMACH DISEASE; STOMACH MOTILITY; STOMACH ULCER;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DOUBLE-BLIND METHOD; FEMALE; GASTROINTESTINAL MOTILITY; HUMANS; INDOMETHACIN; MALE; POSTPRANDIAL PERIOD;

EID: 0031777121     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018883102636     Document Type: Article

References (36)

1. Loeb DS, Ahlquist DA, Talley NJ: Management of gastroduodenopathy associated with use of nonsteroidal anti-inflammatory drugs. Mayo Clin Proc 67:354-364, 1992
2. Parise P, Agnelli G: Antipyretics analgesics. In: Side Effects of Drugs Annual 17. JK Aronson, CJ van Boxtel (eds). Amsterdam, Elsevier Science BV, 1993, pp 94-101
3. Sandor Z, Szabo S: Pharmacologie approaches and pathogenic basis for NSAID gastropathy: Prevention and treatment. Pract Gastroenterol 15:30-43, 1991
4. McCarthy DM: Pathogenic mechanisms of gastroduodenal injury: Nonsteroidal and anti-inflammatory drugs. Curr Opin Gastroenterol 7:976-980, 1991
5. Koop H: Neue Aspekte in der pathogenese des Gastroduodenalulcus. Dtsch Med Wochenschr 117:1243-1246, 1992
6. Scheiman JM: Pathogenesis of gastroduodenal injury due to nonsteroidal antiinflammatory drugs: Implications for prevention and therapy. Semin Arthritis Rheum 21:201-210, 1992
7. Wallace JL: Non-steroidal anti-inflammatory drug gastropathy and cytoprotection: Pathogenesis and mechanisms reexamined. Scand J Gastroenterol 27(suppl 192):3-8, 1992
8. Bjarnason I, Hayllar J, Macpherson AJ, Russel AS: Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 104:1832-1847, 1993
9. Del Favero A: Anti-inflammatory analgesics and drug used in rheumatoid arthritis and gout. In: Side Effects of Drugs Annual 17. JK Aronson, CJ van Boxtel (eds). Amsterdam, Elsevier Science BV, 1993, pp 102-119
10. Mersereau WA, Hinchey EJ: Synergism between acid and gastric contractile activity in the genesis of ulceration and hemorrhage in the phenylbutazone-treated rat. Surgery 90:516-522, 1981
11. Mersereau WA, Hinchey EJ: Prevention of phenylhutazone ulcer in the rat by glucose: Role of glycoprivic receptor system. Am J Physiol 242:G429-G432, 1982
12. Takeuchi K, Ueki S, Okabe S: Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats. Dig Dis Sci 31:1114-1122, 1988
13. Mersereau WA, Hinchey EJ: Relationship between the gastric myoelectric and mechanical activity in the genesis of ulcers in indomethacin-insulin treated rats. Dig Dis Sci 33:200-208, 1988
14. Ueki S, Takeuchi K, Okabe S: Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats. Dig Dis Sci 33:209-216, 1988
15. Frankhuizen AL, Bonta IL: Role of prostaglandins in tone and effector reactivity of the isolated rat stomach preparation. Eur J Pharmacol 31:44-52, 1975
16. Pantoja GL, Defilippi C, Valenzuela JE, Csendes A: Non-steroidal antiinflammatory drugs: Effect on pyloric sphincter and duodenogastric reflux. Dig Dis Sci 24:217-220, 1979
17. Fioramonti J, Bueno L: Gastrointestinal myoelectric activity disturbance in gastric ulcer disease in rats and dogs. Dig Dis Sci 25:575-580, 1980
18. Sanders KM, Szurszewsky JH: Does endogenous prosuiglandin affect gastric antral motility? Am J Physiol 241:G191-G195, 1981
19. Dooley COP, Mello D, Valenzuela JE: Effects of aspirin and prostaglandin E, on interdigestive motility complex and duodenogastric reflux in man. Dig Dis Sci 30:513-521, 1985
20. Schurizek BA, Kraglund K, Andreasen F, Vinter-Jensen L, Juhl B: Antroduodenal motility and gastric emptying. Gastroduodenal motility and pH following ingestion of paracetamol. Aliment Pharmacol Ther 3:93-101, 1989
21. Bassotti G, Bucaneve G, Betti C, Patoia L, Baratta E, Maresca V, Pelli MA, Morelli A, Del Favero A: Effects of parenteral diclofenac sodium on upper gastrointestinal motility after food in man. Eur J Clin Pharmacol 41:497-500, 1991
22. Malagelada JR, Azpiroz F, Mearin F: Gastroduodenal motor function in health and disease. In: Gastrointestinal Disease, 5th ed. MH Sleisenger, JS Fordtran (eds). Philadelphia, WB Saunders, 1993, pp 486-508
23. Mayer EA: The physiology of gastric storage and emptying. In: Physiology of the Gastrointestinal Tract. 3rd ed., LR Johnson (ed). New York, Raven Press, 1994, pp 929-976
24. Bassotti G, Castellucci G, Betti C, Fusaro C, Cavalletti ML, Bertotto A, Spinozzi F, Morelli A, Pelli MA: Abnormal gastrointestinal motility in patients with celiac sprue. Dig Dis Sci 39:1447-1954, 1994
25. Bassotti G, Stanghellini V, Chiarioni G, Germani U, De Giorgio R, Vantini I, Morlli A, Corinaldesi R: Upper gastrointestinal motor activity in patients with slow-transit constipation. Further evidence for an enteric neuropathy. Dig Dis Sci 41:1999-2005, 1996
26. Bassotti G, Bertotto A, Spinozzi F: Heretical thoughts about food hypersensitivity: Small bowel manometry as an objective way to document gut reactions. Eur J Clin Nutr 51:567-572, 1997
27. Malagelada JR, Stanghellini V: Manometric evaluation of functional upper gut symptoms. Gastroenterology 88:1223-1231, 1985
28. Malagelada JR, Camilleri M, Stanghellini V: Manometric Diagnosis of Gastrointestinal Motility Disorders. New York, Thieme, 1986
29. SAS Institute Inc: SAS/STAT (TM) Guide for personal computer. SAS Institute Inc, Carey, North Carolina, 1987
30. Roth SH: Non-steroidal antiinflammatory drugs, gastropathy, deaths and medical practice. Ann Intern Med 109:353-354, 1988
31. Wallace JL: Nonsteroidal antiinflammatory drugs and gastroenteropathy: The second hundred years. Gastroenterology 112:1000-1016, 1997
32. Gustafsson B, Delbro DS: Effects of indomethacin on non-adrenergic, non-cholinergic motility of stomach and small intestine. Eur J Pharmacol 147:67-72, 1988
33. Gutiérrez-Cabano CA: Protection against necrotizing agents-induced gastric lesions in rats. Unrelated to inhibition of gastric motility. Dig Dis Sci 39:1864-1871, 1994
34. Brune K, Dietzel K, Numberg B, Schneider H: Recent insight into the mechanism of gastrointestinal tract ulceration. Scand J Rheumatol 16(suppl 65):135-140, 1987
35. Somasundaram S, Hayllar J, Rafi S, Wrigglesworth J, Macpherson A, Bjarnason I: The biochemical basis of NSAID-induced damage to the gastrointestinal tract: A review and a hypothesis. Scand J Gastrocnterol 30:289-299, 1995
36. Bjarnason I, Hayllar J: Early pathogenic events in NSAID-induced gastrointestinal damage. Ital J Gastroenterol 28(suppl 4):19-22, 1996