Total synthesis and biological activities of (+)- and (-)-boscialin and their 1'-epimers

Journal of Natural Products

Volumn 61, Issue 5, 1998, Pages 591-597

  Busch, Joachim ^a   Grether, Yvonne ^b   Ochs, Dietmar ^c   Séquin, Urs ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c Ciba Grenzach GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BOSCIALIN; ISOPRENOID; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENANTIOMER; MEDICINAL PLANT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; STEREOCHEMISTRY; TRYPANOSOMA BRUCEI;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; ANTIPROTOZOAL AGENTS; CYCLOHEXANOLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; STEREOISOMERISM; TRYPANOSOMA BRUCEI RHODESIENSE; TUMOR CELLS, CULTURED;

EID: 0031777058     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np970517x     Document Type: Article

References (21)

1. Winterhalter, P.; Schreier, P. Flavour Fragrance J. 1994, 9, 281-287.
2. Pérez, C.; Trujillo, J.; Almonacid, L. N.; Trulillo, J.; Navarro, E.; Alonso, S. J. J. Nat. Prod. 1996, 59, 69-72.
3. Bilia, A. R.; Cecchini, C.; Marsili, A.; Morelli, I. J. Nat. Prod. 1993, 56, 2142-2148.
4. Shiraga, Y.; Okano, K.; Akira, T.; Fukaya, C.; Yokoyama, K.; Tanaka, S.; Fukui, H.; Tabata, M. Tetrahedron 1988, 44, 4703-4711.
5. Pauli, N.; Séquin, U.; Walter, A. Helv. Chim. Acta 1990, 73, 578-582.
6. Neuwinger, H. D. Afrikanische Heilpflanzen und Jagdgifte; Wissenschaftliche Verlagsgesellschaft mbh: Stuttgart, 1994.
7. Khan, M. R.; Ndaalio, G.; Nkunya, M. H. H.; Wevers, H.; Sawhney, A. N. Planta Med. (suppl.) 1980, 91-97.
8. Walter, A. Doctoral Dissertation, Universität Basel, Basel, Switzerland, 1989.
9. Otsuka, H.; Takeda, Y.; Yamasaki, K.; Takeda, Y. Planta Med. 1992, 58, 373-375.
10. Lutz, A.; Winterhalter, P.; Schreier, P. Nat. Prod. Lett. 1993, 3, 95-99.
11. Busch, J.; Keserü, G. M.; Kovári, Z.; Séquin, U. Struct. Chem. 1997, 8, 257-261.
12. Busch, J. Doctoral Dissertation, Universität Basel, Basel, Switzerland, 1997.
13. Leuenberger, H. G. W.; Boguth, W.; Widmer, E.; Zell, R. Helv. Chim. Acta 1976, 59, 1832-1849.
14. Lamb, N.; Abrams, S. R. Can. J. Chem. 1990, 68, 1151-1162.
15. Hoffmann, R. W.; Dresely, S. Synthesis 1988, 103-106.
16. Baltz, T.; Baltz, D.; Giround, C.; Crockett, J. EMBO J. 1985, 4, 1273-1277.
17. Räz, B.; Iten, M.; Grether-Bühler, Y.; Kaminsky, R.; Brun, R. Acta Trop. 1997, 68, 139-147.
18. Kaminsky, R.; Schmid, C.; Brun, R. In Vitro Toxicol. 1996, 9, 315-324.
19. Hills, M.; Hudson, C.; Smith, P. G. WHO Document WHO/No. 2.8.5.,WHO: Geneva, 1986.
20. Neal, R. A.; Croft, S. L. J. Antimicrob. Chemother. 1994, 14, 463-475.
21. Zähner, H.; Maas, W. K. Biology of Antibiotics; Springer: New York, 1972.