Conversion from fluvastatin to simvastatin therapy at a dose ratio of 8 to 1: Effect on serum lipid levels and cost

Clinical Therapeutics

Volumn 20, Issue 2, 1998, Pages 340-346

  Rindone, Joseph P ^a   Arriola, Greg ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Clinical trials; Fluvastatin; Hyperlipidemia; Simvastatin

Indexed keywords

CHOLESTEROL; FLUINDOSTATIN; HIGH DENSITY LIPOPROTEIN; LIPID; LOW DENSITY LIPOPROTEIN; SIMVASTATIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; COST CONTROL; COST EFFECTIVENESS ANALYSIS; DRUG COST; FEMALE; HUMAN; HYPERLIPIDEMIA; LIPID BLOOD LEVEL; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE;

EID: 0031776811     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(98)80097-0     Document Type: Article

References (20)

1. Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet. 1994; 344:1383-1389.
2. Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. NEJM. 1995;333:1301-1307.
3. Friedewald WT, Levy RI, Frederickson DS. Estimation of the concentration of low-density lipoprotein in plasma without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
4. Second report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel II). JAMA. 1993;269: 3105-3123.
5. du V Florey C. Sample size for beginners. Lancet. 1993;306:1181-1184.
6. Roberts WC. The rule of 5 and the rule of 7 in lipid lowering by statin drugs. Am J Cardiol. 1997;80:106-107.
7. Yoshino G, Tsutomu K, Matsushita M, et al. Comparison of the effects of pravastatin and simvastatin in hypercholesterolemic subjects. Curr Ther Res. 1990; 48:259-267.
8. Tuomilehto J, Guimaraes AC, Kettner H, et al. Dose-response of simvastatin in primary hypercholesterolemia. J Cardiovasc Pharmacol. 1994;24:941-949.
9. Steinhagen-Thiessen E. Comparative efficacy and tolerability of 5 and 10 mg simvastatin and 10 mg pravastatin in moderate primary hypercholesterolemia. Pravastatin European Study Group. Cardiology. 1994;85:244-254.
10. Peters TK, Mehra M, Muratti EN. Efficacy and safety of fluvastatin in hypertensive patients: An analysis of a clinical trial database. Am J Hypertens. 1993;6(Suppl 11):340S-345S.
11. Illingworth DR, Stein EA, Knopp RH, et al. A randomized multicenter trial comparing the efficacy of simvastatin and fluvastatin. J Cardiovasc Pharmacol Ther. 1996;1:23-30.
12. Ose L, Scott R, and the Simvastatin-Fluvastatin Study Group. Efficacy of simvastatin vs fluvastatin in patients with hypercholesterolemia. Clin Drug Invest. 1995;10:127-138.
13. Sprecher DL, Abrams J, Allen JW, et al. Low-dose combined therapy with fluvastatin and cholestyramine in hyperlipidemic patients. Ann Intern Med. 1994; 120:537-543.
14. Bates MC, Warren SG, Grubb S, Chilag S. Effectiveness of low-dose lovastatin in lowering serum cholesterol: Experience with 56 patients. Arch Intern Med. 1990; 150:1947-1950.
15. Jacobson TA. Cost-effectiveness of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor therapy in the managed care era. Am J Cordiol. 1996;78(6A):32-41.
16. Martens LL, Guibert R. Cost-effectiveness analysis of lipid modifying therapy in Canada: Comparison of HMG-CoA reductase inhibitors in the primary prevention of coronary heart disease. Clin Ther. 1994;16:1052-1062.
17. Spearman ME, Summers K, Moore V, et al. Cost-effectiveness of initial therapy with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors to treat hypercholesterolemia in a primary care setting of a managed-care organization. Clin Ther. 1997;19:582-602.
18. Sedrati M, Arnaud P, Edudes-Fontan J, Brion F. Splitting tablets in half. Am J Hosp Pharm. 1994;51:549-550.
19. Davidson MH, Stein EA, Dujovne CA, et al. The efficacy and six-week tolerability of simvastatin 80 and 160 mg/day. Am J Cardiol. 1997;79:38-42.
20. Rubinstein A, Lurie Y, Groskop I, Weintrob M. Cholesterol-lowering effects of 10 mg daily dose of lovastatin in patients with initial cholesterol levels 200 to 240 mg/dl (5.18 to 6.21 mmol/liter). Am J Cardiol 1991;68:1123-1126.