Placental hormones during induced hypoglycaemia in pregnant women with insulin-dependent diabetes mellitus: Evidence of an active role for placenta in hormonal counter-regulation

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 105, Issue 6, 1998, Pages 649-655

  Bjorklund A O ^a   Adamson, U K C ^a   Carlstrom K A M ^b   Hennen, G ^c   Igout, A ^c   Lins, P E S ^a   Westgren, L M R ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRIOL; GROWTH FACTOR; PLACENTAL PEPTIDE HORMONE; PROLACTIN;

ADULT; ARTICLE; CLINICAL ARTICLE; DATA ANALYSIS; ESTRIOL BLOOD LEVEL; FEMALE; HIGH RISK POPULATION; HORMONAL REGULATION; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; STATISTICAL ANALYSIS; THIRD TRIMESTER PREGNANCY;

ADULT; DIABETES MELLITUS, TYPE 1; ESTRIOL; FEMALE; GROWTH HORMONE; GROWTH SUBSTANCES; HUMANS; HYPOGLYCEMIA; INSULIN; PLACENTA; PLACENTAL HORMONES; PLACENTAL LACTOGEN; PREGNANCY; PREGNANCY IN DIABETICS; PREGNANCY TRIMESTER, THIRD; PROGESTERONE; PROSPECTIVE STUDIES;

EID: 0031776747     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.1998.tb10180.x     Document Type: Article

References (43)

1. Cryer P. Glucose counterregulation: the physiological mechanisms that prevent or correct hypoglycaemia. In: Frier B, Fisher B, editors. Hypoglycaemia and Diabetes. Clinical and Physiological aspects. London: Edward Arnold, 1993: 34–55.
2. Norton M, Buchanan T, Kitzmiller J. Endocrine Pancreas and Maternal Metabolism. In: Tulchinsky D, Little A, editors. Maternal-Fetal Endocrinology. Philadelphia: WB Saunders, 1994: 47–77.
3. Buchanan T. Metabolic changes during normal and diabetic pregnancies. In: Reece E, Coustan D, editors. Diabetes Mellitus in Pregnancy. New York: Churchill Livingstone, 1995: 59–77.
4. Hennen G, Frankenne F, Closset J, Gomez F, Pirens G, El Khayat N. A human placental growth hormone: Increasing levels during second half of pregnancy with pituitary growth hormone suppression as revealed by monoclonal antibody radioimmunoassays. Int J Fertil 1985; 30: 27–33.
5. Eriksson L, Frankenne F, Edtn S, Hennen G, von Schoultz B. Growth hormone 24–hour serum profiles during pregnancy-lack of pulsatility for the secretion of the placental variant. Br J Obstet Gynaecol 1989; 96: 949–953.
6. Frankenne F, Closset J, Gomez F, Scippo M, Smal J, Hennen G. The physiology of growth hormones (GH) in pregnant women and partial characterization of the placental growth hormone variant. J Clin Endocrinol Metab 1988; 66: 1171–1180.
7. Frankenne F, Rentier-Delrue F, Scippo M, Martial J, Hennen G. Expression of the growth hormone variant gene in the placenta. J Clin Endocrinol Metab 1987; 64: 635–663.
8. Frankenne F, Scippo M, van Beeumen J, Igout A, Hennen G. Identification of placental human growth hormone as the growth hormone-V gene expression product. J Clin Endocrinol Metab 1990; 71: 15–18.
9. Spellacy W, Buhi W. Pituitary growth hormone and placental lactogen levels measured in normal term pregnancy and at the early and late postpartum periods. Am J Obstet Gynecol 1969; 105: 888–896.
10. Yen S, Vela P, Tsai C. Impairment of growth hormone secretion in response to hypoglycemia during early and late pregnancy. J Clin Endocr 1970; 31: 29–32.
11. Diamond M, Reece E, Caprios et al. Impairment of counterregulatory hormone responses to hypoglycemia in pregnant women with insulin-dependent diabetes mellitus. Am J Obstet Gynecol 1992; 166: 70–77.
12. Siiteri P, MacDonald P. Placental estrogen biosynthesis during human pregnancy. J Clin Endocrinol Metab 1966; 26:751–761.
13. Bjorklund A, Adamson U, Almstrom N et al. Effects of hypoglycaemia on fetal heart activity and umbilical artery Doppler velocity waveforms in pregnant women with insulin-dependent diabetes mellitus. Br J Obstet Gynaecol 1996; 103 413–420.
14. Karlsson K, Kjellmer I. The outcome of diabetic pregnancies in relation to the mother's blood sugar level. Am J Obstet Gynecol 1972; 112: 213–220.
15. Reece E, Homko C. Glucose evaluation and control. In: Reece, E, Coustan, D, editors. Diabetes Mellitus in Pregnancy. New York: Churchill Livingstone, 1995: 155–171.
16. Raybum W, Piehl E, Jacober S, Schork A, Ploughman L. Severe hypoglycemia during pregnancy, its frequency and predisposing factors in diabetic women. Int J Gynecol Obstet 1986; 24: 263–268.
17. Tymms DJ, Callaway PL, Leatherdale BA, Wheeler T. Audit of outpatient management of 99 pregnancies in patients with diabetes [abstract]. Diab Med 1987; 4 (Suppl): 578 A.
18. Steel JM, Johnstone FD, Smith AFM. Pre-pregnancy preparation. In: Sutherland HW, Stowers JM, Pearson DWM, editors. Carbohydrate Metabolism in Pregnancy and the Newborn IV. Berlin:Springer-Verlag., 1989 129–139.
19. Kimmerle R, Heinemann L, Delecki A, Berger M. Severe hypoglycemia incidence and predisposing factors in 85 pregnancies of type 1 diabetic women. Diab Care 1992; 15: 1034–1037.
20. The DCCT Research Group. Diabetes Control and Complications Trial (DCCT): results of feasibility study. Diabetes Care 1987; 10: 1–19.
21. Reichard P, Britz A, Cars I, Nilsson B, Sobocinsky-Olsson B. The Stockholm Diabetes Intervention Study (SDIS): 18 months' results. Acta Med Scand 1988; 224: 115–122.
22. The DCCT Research Group. Epidemiology of Severe Hypoglycemia in the Diabetes Control and Complications Trial. AmJ Med 1991;90:450–459.
23. Geirsson G, Patel N, Christie A. In-vivo accuracy of ultrasound measurements of intrauterine volume in pregnancy. Br J Obstet Gynaecol 1984; 91: 37–39.
24. Geirsson G. Intrauterine volume in pregnancy. Acta Obstet Gynecol Scand 1986: (Suppl 136): 50–52.
25. 125in insulin-dependent diabetic mothers. J Clin Endocrinol Metab 1975; 40: 139–142.
26. Jones C. Endocrine function of the placenta. In: Jones C, editor. Perinatal Endocrinology. London: Baillidre Tindall, 1989 755–780.
27. Tulchinsky D, Little A. Maternal-Fetal Endocrinology. Philadelphia: WB Saunders, 1994.
28. Igout A, Hennen G. The human growth hormone variant: a review. Trophobl Res 1997; 10 345–352.
29. Evain-Brion D, Alsat E, Igout A, Frankenne F, Hennen G. Placental growth hormone variant: assay and clinical aspects. Acta Paediatr 1994; 399 (Suppl): 49–51.
30. Patel N, Alsat E, Igout A et al. Glucose inhibits human placental growth hormone secretion, in vitro. J Clin Endocrinol Metab 1995; 80: 1743–1746.
31. Zeitler P, Markoff E, Handwerger S. Characterization of the synthesis and release of human placental lactogen and human chorionic gonadotrophin by an enriched population of placental cells. J Clin Endocrinol Metab 1983; 57: 812–817.
32. Chen E, Liao Y, Smith D, Barrera-Saldana H, Gelinas R, Seeburg P. The human growth hormone locus: nucleotide sequence, biology and evolution. Genomics 1989; 4 479–491.
33. Seeburg P. The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. DNA 1982; 1: 239–249.
34. Liebhaber S, Urbanek M, Ray J, Tuan R, Cooke N. Characterization and histological localization of human growth hormone-variant gene expression in the placenta. J Clin Invest 1989; 83: 1985–1991.
35. Jara C, Salud A, Bryant-Geenwood G, Pirens G, Hennen G, Frankenne F. Immunocytochemical localization of the human growth hormone variant in the human placenta. J Clin Endocrinol Metab 1989; 69 1069–1072.
36. Mc Williams D, Boime I. Cytological localization of placental lactogen messenger ribonucleic acid in syncytiotrophoblast layers of human placenta. Endocrinology 1980; 107: 761–765.
37. Scippo M, Frankenne F, Hooghe-Peters E, Igout A, Velkeniers B, Hennen G. Syncytiotrophoblast localization of the human growth hormone variant mRNA in the placenta. Mol Cell Endocrinol 1992; 92: R7–R13.
38. Eriksson L, Frankenne F, Eden S, Hennen G, von Schoultz B. Growth hormone secretion during termination of pregnancy. Acta Obstet Gynecol Scand 1988; 67: 549–552.
39. Falcone T, Little A. Placental polypeptides In: Tulchinsky, D., Little A, editors. Maternal-Fetal Endocrinology. Philadelphia: WB Saunders, 1994: 15–32.
40. Falcone T, Little A. Placental synthesis of steroid hormones. In: Tulchinsky D, Little A, editors. Maternal-Fetal Endocrinology. Philadelphia: WB Saunders, 1994 1–14.
41. Fisher B, Frier B. Haemodynamic responses and functional changes in major organs. In: Frier B, Fisher B, editors. Hypoglycaemia and Diabetes. Clinical and Physiological aspects. London: Edward Arnold, 1993: 144–155.
42. Simmer H, Tulchinsky D, Gold E, Frankland M, Greipel M, Gold A. On the regulation of estrogen production by cortisol and ACTH in the human pregnancy at term. Am J Obstet Gynecol 1974; 119: 283–296.
43. Kirkpatrick C, Alexander C, Vanbellinghen A, Schwers J. Serum unconjugated estriol after intravenous cortisol administration in late pregnancy. Obstet Gynecol 1979; 53: 627–629.