Changes in contraction, cytosolic Ca2+ and pH during metabolic inhibition and upon restoration of mitochondrial respiration in rat ventricular myocytes

Experimental Physiology

Volumn 83, Issue 3, 1998, Pages 349-360

  Lancaster, Matthew K ^a   Harrison, Simon M ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; CYANIDE; DEOXYGLUCOSE; IODOACETIC ACID; OLIGOMYCIN;

ACIDOSIS; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL PH; CONTRACTURE; CONTROLLED STUDY; CYTOSOL; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE WALL; METABOLIC INHIBITION; MITOCHONDRIAL RESPIRATION; NONHUMAN; PHOSPHORYLATION; RAT;

EID: 0031776654     PISSN: 09580670     EISSN: None     Source Type: Journal    
DOI: 10.1113/expphysiol.1998.sp004118     Document Type: Article

References (26)

1. ALLEN, D. G., MORRIS, P. G., ORCHARD, C. H. & PIROLO, J. S. (1985). A nuclear magnetic resonance study of metabolism in the ferret heart during hypoxia and inhibition of glycolysis. Journal of Physiology 361, 185-204.
2. ALLEN, D. G. & ORCHARD, C. H. (1983). Intracellular calcium concentration during hypoxia and metabolic inhibition in mammalian ventricular muscle. Journal of Physiology 339, 107-122.
3. ALLEN, D. G. & ORCHARD, C. H. (1987). Myocardial contractile function during ischaemia and hypoxia. Circulation Research 60, 153-168.
4. ALLSHIRE, A., PIPER, H. M., CUTHBERTSON, K. R. & COBBOLD, P. H. (1987). Cytosolic free Ca in single rat heart cells during anoxia and reoxygenation. Biochemical Journal 244, 381-385.
5. BOWERS, K. C., ALLSHIRE, A. P. & COBBOLD, P. H. (1993). Continuous measurements of cytoplasmic ATP in single cardiomyocytes during simulation of the oxygen paradox. Cardiovascular Research 27, 1836-1839.
6. BOYETT, M. R., MOORE, M., JEWELL, B. R., MONTGOMERY, R. A. P., KIRBY, M. S. & ORCHARD, C. H. (1988). An improved apparatus for the optical recording of contraction of single heart cells. Pflügers Archiv 413, 197-205.
7. CANNINGS, I., HARRISON, S. M., WHITE, E. & BOYETT, M. R. (1993). The effect of a range of alcohols on the contraction of guinea-pig ventricular myocytes. European Journal of Pharmacology 248, 213-216.
8. DONOSO, P., MILL, J. G., O'NEILL, S. C. & EISNER, D. A. (1992). Fluorescence measurements of cytoplasmic and mitochondrial sodium concentration in rat ventricular myocytes. Journal of Physiology 448, 493-509.
9. EISNER, D. A., NICHOLS, C. G., O'NEILL, S. C., SMITH, G. L. & VALDEOLMILLOS, M. (1989). The effects of metabolic inhibition on intracellular calcium and pH in isolated rat ventricular cells. Journal of Physiology 411, 393-418.
10. ELLIOTT, A. C., SMITH, G. L., EISNER, D. A. & ALLEN, D. G. (1992). Metabolic changes during ischaemia and their role in contractile failure in isolated ferret hearts. Journal of Physiology 454, 467-490.
11. ELLIS, D. & NOIREAUD, J. (1987). Intracellular pH in sheep Purkinje fibres and ferret papillary muscles during hypoxia and recovery. Journal of Physiology 383, 125-141.
12. FABIATO, A. & FABIATO, F. (1975). Effects of magnesium on contractile activation of skinned cardiac cells. Journal of Physiology 249, 497-517.
13. FABIATO, A. & FABIATO, F. (1978). Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiac and skeletal muscles. Journal of Physiology 276, 233-255.
14. + during acidosis in rat ventricular myocytes. American Journal of Physiology 262, C348-357.
15. HARRISON, S. M., MCCALL, E. & BOYETT, M. R. (1992). The relationship between contraction and intracellular sodium in rat and guinea-pig ventricular myocytes. Journal of Physiology 449, 517-550.
16. HEARSE, D. J. (1995). Oxygen deprivation and early myocardial contractile failure: reassessment of the possible role of adenosine triphosphate. American Journal of Cardiology 44, 1115-1121.
17. KENTISH, J. C. (1986). The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rat ventricle. Journal of Physiology 370, 585-604.
18. KENTISH, J. C. (1991). Combined inhibitory actions of acidosis and phosphate on maximum force production in rat skinned cardiac muscle. Pflügers Archiv 419, 310-318.
19. KUSUOKA, H. & MARBAN, E. (1992). Cellular mechanisms of myocardial stunning. Annual Review of Physiology 54, 243-256.
20. LEDERER, W. J., NICHOLS, C. G. & SMITH, G. L. (1989). The mechanism of early contractile failure of isolated rat ventricular myocytes subjected to complete metabolic inhibition. Journal of Physiology 413, 329-349.
21. MCCLELLAN, G. B. & WINEGRAD, S. (1978). The regulation of the calcium sensitivity of the contractile system in mammalian cardiac muscle. Journal of General Physiology 72, 737-764.
22. ORCHARD, C. H. & KENTISH, J. C. (1990). Effects of changes of pH on the contractile function of cardiac muscle. American Journal of Physiology 258, C967-981.
23. PIROLO, J. S. & ALLEN, D. G. (1986). Assessment of techniques for preventing glycolysis in cardiac muscle. Cardiovascular Research 20, 837-844.
24. SILVERMAN, H. S. & STERN, M. D. (1994). Ionic basis of ischaemic cardiac injury: Insights from cellular studies. Cardiovascular Research 28, 581-597.
25. SMITH, G. L. & ALLEN, D. G. (1988). Effects of metabolic blockade on intracellular calcium concentration in isolated ferret ventricular muscle. Circulation Research 62, 1223-1236.
26. SMITH, G. L., DONOSO, P., BAUER, C. J. & EISNER, D. A. (1993). Relationship between intracellular pH and metabolite concentrations during metabolic inhibition in isolated ferret heart. Journal of Physiology 472, 11-22.