Synthesis of (S)-1-(2',3'-dihydroxypropyl)-2-alkylthiouracils as new antiviral agents

Pharmazie

Volumn 53, Issue 6, 1998, Pages 377-380

  Abdel Rahman, A A H ^a   Abdel Aal, M T ^a  

^a Menoufia University   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2',3' DIHYDROXYPROPYL) 2 ALKYLTHIOURACIL; 1,3 DIOXOLANE DERIVATIVE; ACETIC ACID; ACICLOVIR; ANTIVIRUS AGENT; N,N DIMETHYLFORMAMIDE; NEW DRUG; NUCLEOSIDE; PHOSPHINE DERIVATIVE; PYRIDINE DERIVATIVE; SODIUM AZIDE; THIOURACIL DERIVATIVE; TOLUENESULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; VIRUS INHIBITION;

ANTI-HIV AGENTS; HEPATITIS B VIRUS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; THIOURACIL; VIRUS REPLICATION;

EID: 0031775620     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Elion, G. B.; Furman, P. A.; Fyle, J. A.; de Maranda, P.; Beauchamp, L.; Schaeffer, H. J.: Proc. Acad. Sci. USA 74, 5716 (1977)
2. Schaeffer, H. J.; Beauchamp, L.; de Miranda, P.; Elion, G.; Bauer, D. J.; Cillins, P.: Nature (London) 272, 583 (1978)
3. The Proceedings of Symposium on Acyclovir: Am. J. Med. 73, (1 H) (1982)
4. Jaffe, J.: Ann. N.Y. Acad. Sci. 255, 306 (1975)
5. De Clerq, E.; Torrence, P. F.: J. Carb. Nucleos Nucleot 5, 187 (1978)
6. De Clerq, E.; Descamps, J.; De Somer, P.; Holy, A.: Science 200, 563 (1978)
7. La Montagne, M. P.; Smith, D. C.; Wu, G. S.: J. Heterocycl. Chem. 20, 295 (1983)
8. Houston, D. M.; Dolence, E. K.; Kellor, B. T.; Patel-Thombre, U.; Borchardt, R. T.: J. Med. Chem. 28, 467 (1985)
9. Abdel-Rahman, A. A.-H.; Abdel-Bary, H. M.; Pedersen, E. B.; Nielsen, C.: Arch. Pharm. 328, 67 (1995)
10. Abdel-Rahman, A. A.-H.; Zahran, M. A.; Abdel-Megied, A. E.-S.; Pedersen, E. B.; Nielsen, C.: Synthesis, 237 (1996)
11. Zahran, M. A.; Abdel-Megied, A. E.-S.; Abdel-Rahman, A. A.-H.; El- Emam, A.; Pedersen, F. B.; Nielsen, C.: Heterocycles 41, 2507 (1996)
12. Zahran, M. A.; Abdel-Megied, A. E.-S.; Abdel-Rahman, A. A.-H.; Sofan, M. A.; Pedersen, E. B.; Nielsen, C.: Monatsh. Chem. 127, 979 (1996)
13. Abdel-Rahman, A. A.-H.: AFINIDAD 54, 135 (1997)
14. Border, S.: Pharm. Technol. 12, 24 (1988)
15. Brown, T. H.; Blakemore, R. C.; Emmett, G. J.; Robin, G. C.; Parsons, M. E.; Anthony, D. A.; Walker, T. F.: J. Med. Chem. 23, 53 (1988)
16. Holy, A.: Collect Czech. Chem. Commun. 40, 187 (1975)