Swelling-activated chloride currents in a drug-sensitive cell line and a P glycoprotein-expressing derivative are underlied by channels with the same pharmacological properties

Cellular Physiology and Biochemistry

Volumn 8, Issue 5, 1998, Pages 246-260

  Horton, Julie K ^a,b   Vanoye, Carlos G ^a   Reuss, Luis ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Chloride channels; Multidrug resistance; P glycoprotein

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; CHLORIDE ION; COLCHICINE; CYTOCHALASIN D; DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; RHODAMINE 123; VERAPAMIL; VINBLASTINE; VINCRISTINE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL SWELLING; CHLORIDE CURRENT; CONTROLLED STUDY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

EID: 0031775070     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000016287     Document Type: Article

References (42)

1. Roninson IB: Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells. New York, Plenum Press, 1991.
2. Gottesman MM, Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 1993;62:385-427.
3. Ford JM: Modulators of multidrug resistance. Hematol Oncol Clin North Am 1995;9:337-361.
4. Hyde SC, Emsley P, Hartshorn MJ, Mimmack MM, Gileadi U, Pearce SR, Gallagher MP, Gill DR, Hubbard RE, Higgins CF: Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 1990;346:362-365.
5. Anderson MP, Gregory RJ, Thompson S, Souza DW, Paul P, Mulligan RC, Smith AE, Welsh MJ: Demonstration that CFTR is a chloride channel by alteration of its ion selectivity. Science 1991;253:202-205.
6. Stutts MJ, Canessa C, Olson JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC: CFTR as a cAMP-dependent regulator of sodium channels. Science 1995;269:847-850.
7. Schwiebert EM, Egan ME, Hwang T-H, Fulmer SB, Allen SA, Cutting GR, Guggino WB: CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell 1995;81: 1063-1073.
8. Valverde MA, Diaz M, Sepulveda FV, Gill DR, Hyde SC, Higgins CF: Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein. Nature 1992;355:830-833.
9. Gill DR, Hyde SC, Higgins CF, Valverde MA, Mintenig GM, Sepulveda FV: Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein. Cell 1992;71:23-32.
10. Roepe PD: The role of the MDR protein in altered drug translocation across cell membranes. Biochim Biophys Acta 1995;1241:385-406.
11. Rasola A, Galietta LJV, Gruener DC, Romeo G: Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression of the MDR-1 gene. J Biol Chem 1994;269:1432-1436.
12. Ehring GR, Osipchuk YV, Cahalan MD: Swelling-activated chloride channels in multidrug-sensitive and -resistant cells. J Gen Physiol 1994; 104:1129-1161.
13. Han ES, Vanoye CG, Altenberg GA, Reuss L: P-glycoprotein-associated chloride currents revealed by specific block by an anti-P-glycoprotein antibody. Am J Physiol 1996;270: C1370-C1378.
14. Morin XK, Bond TD, Loo TW, Clarke DM, Bear CE: Failure of P-glycoprotein (MDR1) expressed in Xenopus oocytes to produce swelling-activated chloride channel activity. J Physiol (Lond) 1995;486:707-714.
15. Aleu J, Ivorra I, Lejarreta M, Gonzalezros JM, Morales A, Ferragut JA: Functional incorporation of P-glycoprotein into Xenopus oocyte plasma membrane fails to elicit a swelling-evoked conductance. Biochem Biophys Res Commun 1997; 237:407-412.
16. Hardy SP, Goodfellow HR, Valverde MA, Gill DR, Sepulveda FV, Higgins CF: Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels. EMBO J 1995;14:68-75.
17. - channel regulator. J Physiol (Lond) 1997;502:249-258.
18. Mintenig GM, Valverde MA, Sepulveda FV, Gill DR, Hyde SC, Kirk J, Higgins CF: Specific inhibitors distinguish the chloride channel and drug transport functions associated with the human multidrug resistance P-glycoprotein. Receptors Channels 1993;1:305-313.
19. Fatherazi S, Izutsu KT, Wellner RB, Belton CM: Hypotonically activated chloride channels in HSG cells. J Membr Biol 1994;142:181-193.
20. Schwiebert EM, Mills JW, Stanton BA: Actin-based cytoskeleton regulates a chloride channel and cell volume in a renal cortical collecting duct cell line. J Biol Chem 1994; 269:7081-7089.
21. Fairchild CR, Moscow JA, O'Brien EE, Cowan KH: Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase-π. Mol Pharmacol 1990;37: 801-809.
22. Hamill OP, Marly A, Neher E, Sakmann B, Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 1981;391: 85-100.
23. Viana F, Van Acker K, De Greef C, Eggermont J, Raeymaekers L, Droogmans G, Nilius B: Drug-transport and volume-activated chloride channel functions in human erythroleukemia cells: Relation to expression level of P-glycoprotein. J Membr Biol 1995;145:87-98.
24. Dustin P: Microtubules, ed 2. Berlin, Springer, 1984, pp 171-179.
25. Osipchuk YV, Ehring GR, Cahalan MD: A novel mechanism of action for chemosensitizing agents (abstract). Biophys J 1995;68:A121.
26. Wang X, Wall DM, Parkin JD, Zalcberg JR, Kemm RE: P-glycoprotein expression in classical multi-drug resistant leukemia cells does not correlate with enhanced chloride channel activity. Clin Exp Pharmacol Physiol 1994;21:101-108.
27. Dong Y, Chen G, Duran GE, Kouyama K, Chao AC, Sikic BI, Gollapudi SV, Gupta S, Gardener P: Volume-activated chloride current is not related to P-glycoprotein over-expression. Cancer Res 1994;54: 5029-5032.
28. Kirk J, Houlbrook S, Stuart NSA, Stratford I, Harris AL, Carmichael J: Selective reversal of vinblastine resistance in multidrug-resistant cell lines by tamoxifen, toremifene and their metabolites. Eur J Cancer 1993;29A:1152-1157.
29. Valverde MA, Bond TD, Hardy SP, Taylor JC, Higgins CF, Altamirano J, Alvarez-Leefmans FJ: The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease. EMBO J 1996;15:4460-4468.
30. - channel in renal proximal tubule cells. J Mcmbr Biol 1993;134:31-39.
31. + channel activity. Am J Physiol 1991;261:C882-C888.
32. Canticllo HF: Role of the actin cytoskeleton in the regulation of the cystic fibrosis transmembrane conductance regulator. Exp Physiol 1996;81:505-514.
33. Cornet M, Ubl J, Kolb H-A: Cytoskeleton and ion movements during volume regulation in cultured PC 12 cells. J Membr Biol 1993;133:161-170.
34. Mills JW, Schwcibert EM, Stanton BA: The cytoskeleton and cell volume regulation: in Strange K (ed): Cellular and Molecular Physiology of Cell Volume Regulation. Boca Raton, CRC Press, 1994, pp 241-258.
35. Jirsch JD, Loe DW, Cole SPC, Deelcy R, Fedida D: ATP is not required for anion current activated by cell swelling in multidrug-resistant lung cancer cells. Am J Physiol 1994;267:C688-C699.
36. Sardini A, Mintenig GM, Valverde MA, Scpulveda FV, Gill DR, Hyde SC, Higgins CF, McNaughton PA: Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling. J Cell Sci 1994;107:3281-3290.
37. Altenberg GA, Vanoye CG, Han ES, Deitmer JW, Reuss L: Relationships between rhodamine 123 transport, cell volume, and ion-channel function of P-glycoprotein. J Biol Chem 1994;269:7145-7149.
38. Ambasch K, Cabantchik ZI, Slotki IN: Effects of hypotonie and hypoionic media on drug pumping by P-glycoprotcin expressed in epithelial and nonepithelial cell lines. J Cell Physiol 1995;164:117-122.
39. Weaver JL, McKinney L, Schoenlein PV, Goldenberg S, Gottesman MM, Aszalos A: MDR1/P-glycoprotein function. I. Effect of hypotonicity and inhibitors on rhodamine 123 exclusion. Am J Physiol 1996;270: C1447-C1452.
40. Horio M, Gottesman MM, Pastan I: ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc Natl Acad Sci USA 1988;85:3580-3584.
41. Yusa K, Tsuruo T: Reversal mechanism of multidrug resistance by verapamil: Direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells. Cancer Res 1989;49:5002-5006.
42. - currents by P-glycoprotein (Pgp) (abstract). FASEB J 1997;11:A304.