Reversal of severe pulmonary hypertension with β blockade in a patient with end stage left ventricular failure

Heart

Volumn 80, Issue 6, 1998, Pages 620-622

  Crilley, J G ^a   Dark, J H ^b   Hall, J A ^a  

^a JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

^b FREEMAN HOSPITAL   (United Kingdom)

Author keywords

Heart failure; Pulmonary hypertension; Transplantation; Blockers

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DOBUTAMINE; LISINOPRIL; METOPROLOL; SALBUTAMOL;

ADULT; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CASE REPORT; CLINICAL FEATURE; DRUG EFFICACY; HEART LEFT VENTRICLE FAILURE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; TREATMENT OUTCOME;

EID: 0031774807     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/hrt.80.6.620     Document Type: Article

References (21)

1. Leier CV, Webel J, Bush CA. The cardiovascular effects of the continuous infusion of dobutamine in patients with severe cardiac failure. Circulation 1977;56:468-72.
2. Rotstein Z, Battler A, Rath S, et al. Acute haemodynamic and arrythmogenic effects of high-dose intravenous salbutamol in patients with chronic left ventricular dysfunction. Clinical Cardiology 1990;13:468-72.
3. Packer M. Pathophysiology of chronic heart failure. Lancet 1992;340:88-95.
4. Cohn JN, Levine TB, Olivari MT, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 1984;311:819-23.
5. The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive cardiac failure: results of the cooperative north Scandinavian enalapril survival study (CONSENSUS). N Engl J Med 1982;316:1429-35.
6. The SOLVD Investigators. Effect of enalapril on survival in patients reduced left ventricular function and congestive heart failure. N Engl J Med 1991;325:293-302.
7. Cohn JN, Johnson G, Ziesche RV, et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 1991;325:303-10.
8. Waagstein F, Bristow MR, Swedburg K, et al. Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Lancet 1993;342:1441-6.
9. CIBIS Investigators and Committees. A randomized trial of β blockade in heart failure - the cardiac insufficiency bisoprolol study (CIBIS). Circulation 1994;90:1765-73.
10. Packer M, Bristow MR, Cohn JN, et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med 1996;334:1349-55.
11. Bristow MR, Grinsburg R, Mihobe W, et al. Decreased catecholamine sensitivity and beta-adrenergic density in failing human hearts. N Engl J Med 1982;305:205-11.
12. Colucci WS, Denniss AR, Leatherman GF, et al. Intracoronary infusion of dobutamine to patients with and without severe congestive cardiac failure. J Clin Invest 1988;81: 1103-10.
13. Sandoval A, Gilbert EM, Rassmusen R, et al. Is β1 receptor down-regulation in the failing human heart the result of cardiac-derived noradrenaline [abstract]. J Am Coll Cardiol 1988;11:117A.
14. Rassmussen R, Shah P, Larrabee P, et al. β1 and β2 receptor down-regulation associated with β agonist administration in the failing human heart [abstract]. Circulation 1987;76: IV-307.
15. Bristow MR, Hershberger RE, Port DJ, et al. β1-and β2-adrenergic receptor-mediated adenylate cyclase stimulation in non-failing and failing human ventricular myocardium. Mol Pharmacol 1989;35:295-303.
16. Steinfath M, Danielsen W, von der Leyen H, et al. Reduced β1-and β2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure. Br J Pharmacol 1992;105:463-9.
17. Hall JA, Kaumann AJ, Brown MJ. Selective β1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through β2-adrenoceptors in human atrial myocardium. Circ Res 1990;66:1610-23.
18. Hall JA, Petch MC, Brown MJ. In vivo demonstration of cardiac β2-adrenoreceptor sensitisation by β1-antagonist treatment. Circ Res 1991;69:959-64.
19. Hall JA, Petch MC, Brown MJ. Intracoronary injections of salbutamol demonstrate the presence of functional β2-adrenoreceptors in the human heart. Circ Res 1989;65:546-53.
20. Zerkowski HR, Ikezono K, Rohm N, et al. Human myocardial β adrenoceptors: demonstration of both β1 and β2 adrenoceptors mediating contractile responses to β agonists on the isolated right atrium. Naunyn Schmiedebergs Arch Pharmacol 1986;332:142-7.
21. Heilbrunn SM, Shah P, Bristow MR, et al. Increased β receptor density and improved haemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy. Circulation 1989;79:483-90.