Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption

Xenobiotica

Volumn 28, Issue 11, 1998, Pages 1083-1092

  Johansen, P B ^a   Hansen, K T ^a   Andersen, J V ^a   Johansen, N L ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 (AMINOMETHYL)BENZOYL DEXTRO (2 NAPHTHYL)ALANYL N METHYL DEXTRO PHENYLALANYLLYSYLAMIDE; GROWTH HORMONE DERIVATIVE; IPAMORELIN; NNC 26 0194; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXCRETION; DRUG METABOLISM; INTRANASAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; NOSE MUCOSA; ORAL DRUG ADMINISTRATION; PLASMA CLEARANCE; RAT; URINARY EXCRETION;

ANIMALIA;

EID: 0031774430     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982598238976     Document Type: Article

References (32)

1. AGERHOLM, P. C., BASTHOLM, L., JOHANSEN, P. B., NIELSEN, M. H. and ELLING, F., 1994, Epithelial transport and bioavailability of intranasally administered human growth hormone formulated with the absorption enhancers didecanoyl-L-α-phosphatidylcholine and α-cyclodextrin in rabbits. Journal of Pharmaceutical Sciences, 83, 1706-1711.
2. BELLONE, J., GHIZZONI, L., AIMARETTI, G., VOLTA, C., BOGHEN, M. F., BERNASCONI, S. and GHIGO, E., 1995, Growth hormone-releasing effect of oral growth hormone-releasing peptide 6 (GHRP-6) administration in children with short stature. European Journal of Endocrinology, 133, 425-429.
3. BOWERS, C. Y., CHANG, J., MOMANY, F. and FOLKERS, K., 1977, Effects of the enkephalins and enkephalin analogs on release of pituitary hormones in vitro. In I. MacIntyre (ed.), Molecular Endocrinology (Amsterdam: Elsevier), p 287.
4. BOWERS, C. Y., MOMANY, F. A., REYNOLDS, G. A. and HONG, A., 1984, On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology, 114, 1537-1545.
5. CAMANNI, F., GHIGO, E. and ARVAT, E., 1998, Growth hormone-releasing peptides and their analogs. Frontiers in Neuroendocrinology, 19, 47-72.
6. 2.5] Enkephalin in rats. Pharmaceutical Research, 14, 345-350.
7. DAVIS, C. B., CRYSLER, C. S., BOPPANA, V. K., FONG, K.-L. L., JOSEPH, G. L., URBANSKI, J. J., MACIA, R. A. and RHODES, G. R., 1994, Disposition of growth hormone-releasing peptide (SK&F 110679) in rat and dog following intravenous or subcutaneous administration. Drug Metabolism and Disposition, 22, 90-98.
8. 3H methionine-enkephalin by various rat tissues in vivo and in vitro. Life Sciences, 21, 907-914.
9. GHIGO, E., ARVAT, E., GIANOTTI, L., IMBIMBO, B. P., LENAERTS, V., DEGHENGHI, R. and CAMANNI, F., 1994, Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, intranasal, and oral administration in man. Journal of Clinical Endocrinology and Metabolism, 78, 693-698.
10. GILLESPIE, W. R., 1991, PCDCON v.1.0 (Houston: University of Texas).
11. GILLESPIE, W. R. and VENG-PEDERSEN, P., 1985, A polyexponential deconvolution method: Evaluation of the 'gastro-intestinal bioavailability' and mean in vivo dissolution time of some ibuprofen dosage forms. Pharmacokinetics and Biopharmaceutics, 13, 289-307.
12. GORES, G. J., LARUSSO, N. F. and MILLER, L. J., 1986, Hepatic processing of cholecystokinin peptides. I. Structural specificity and mechanism of hepatic extraction. American Journal of Physiology, 250, G344-349.
13. HARTMAN, M. L., FARELLO, G., PEZZOLI, S. and THORNER, M. O., 1992, Oral administration of growth hormone (GH)-releasing peptide stimulates GH secretion in normal men. Journal of Clinical Endocrinology and Metabolism, 74, 1378-1384.
14. 2 (growth hormone releasing peptide) increased plasma growth hormone and insulin-like growth factor-1 levels in normal men. Endocrinology Japon, 38, 15-21.
15. HEINZEL, G., WOLOSZCZAK, R. and THOMANN, P., 1993, Pharmacokinetic and Pharmacodynamic Data Analysis System for the PC. TOPFIT, 2nd edn (Stuttgart: Gustav Fisher).
16. HUSSAIN, A. A., HIRAI, S. and BAWARSHI, R., 1980, Nasal absorption of propranolol from different dosage forms by rats and dogs. Journal of Pharmaceutical Sciences, 69, 1411-1413.
17. LARON, Z., FRENKEL, J., GIL-AD, I., KLINGER, B., LUBIN, E., WUTHRICH, P., BOUTIGNIN, F., LENGERTS, V. and DEGHENGHI, R., 1994, Growth hormone releasing activity by intranasal administration of a synthetic hexapeptide (hexarelin). Clinical Endocrinology, 41, 539-541.
18. LARON, Z., FRENKEL, J., DEGHENGHI, R., ANIN, S., KLINGER, B. and SILBERGELD, A., 1995, Intranasal administration of the GHRP hexarelin accelerates growth in short children. Clinical Endocrinology, 43, 631-635.
19. MCCORMICK, G. F., MILLARD, W. J., BADGER, T. M., BOWERS, C. Y. and MARTIN, J. B., 1985, Dose-response characteristics of various peptides with growth hormone releasing activity in the unanesthetized male rat. Endocrinology, 117, 97-105.
20. MCMARTIN, C, HUTCHINSON, L. K. F., HYDE, R. and PETERS, G. E., 1987, Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity. Journal of Pharmaceutical Sciences, 76, 535-540.
21. MOMANY, F. A., BOWERS, C. Y., REYNOLDS, G. A., CHANG, D., HONG, A. and NEWLANDER, K., 1984, Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides. Endocrinology, 114, 1531-1536.
22. 2 in conscious dogs. Life Sciences, 48, 2283-2288.
23. PIHOKER, C., MIDDLETON, R., REYNOLDS, G. A., BOWERS, C. Y. and BADGER, T. M., 1995, Diagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature. Journal of Clinical Endocrinology and Metabolism, 80, 2987-2992.
24. PONG, S.-S., CHACNG, L.-Y. P., DEAN, D. C., NARGUND, R. P., PATCHETT, A. A. and SMITH, R. G., 1996, Identification of a new G-protein-linked receptor for growth hormone secretagogues. Molecular Endocrinology, 10, 57-61.
25. RAUN, K, HANSEN, B. S., JOHANSEN, N. L., THØGERSEN, H., MADSEN, K., ANDERSEN, P. H. and ANKERSEN, M., 1998, Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology (in press).
26. READON, P. M., GOCHOCO, C. H., AUDUS, K. L., WILSON, G. and SMITH, P. L., 1993, In vitro nasal transport across ovine mucosa: effects of ammonium glycyrrhizinate on electrical properties and permeability of growth hormone releasing peptide, mannitol, and lucifer yellow. Pharmaceutical Research, 10, 553-561.
27. ROUMI, M., MARLEAU, S., BOGHEN, M., NILSSON, M., DU SOUICH, P. and ONG, H., 1997, Hepatic extraction of hexarelin, a new peptidic GH secretagogue, in the isolated perfused rat liver. Pharmaceutical Research, 14, 1008-1013.
28. 2(GHRP-6) in the rat. Endocrinology, 117, 1441-1447.
29. SMITH, R. G., VAN DER PLOEG, H. A. D., FEIGHNER, S. D., CHENG, K., HICKEY, G. J., WYVRATT, M. J., FISHER, M. H., NAHGUND, R. P. and PATCHETT, A. A., 1997, Peptidomimetic regulation of growth hormone secretion. Endocrine Reviews, 18, 621-645.
30. SU, K. S., CAMPANALE, K. M. and GRIES, C. L., 1984, Nasal drug delivery system of a quaternary ammonium compound. Journal of Pharmaceutical Sciences, 73, 1251-1254.
31. VORA, J. K., CHRISTENSEN, G. A., REGINATO, M. J., MACIA, R. A., GOCHOCO, C. H. and OH C. K., 1993, Influence of formulation variables on plasma growth hormone levels following intranasal administration of growth hormone-releasing peptide in anesthetized rats. Journal of Controlled Release, 24, 193-200.
32. ZIEGLER, K., KOLAC, C., SCHULZE, S., WENZEL, U. and KEMMER, H., 1996, Hepatobiliary elimination of certain peptide-mimicking drugs: linear hydrophobic and hydrophilic renin-mhibitors and hydrophobic cyclopeptides. Journal of Hepatology, 24, 47-52.