The equine herpesvirus 1 IR6 protein that colocalizes with nuclear lamins is involved in nucleocapsid egress and migrates from cell to cell independently of virus infection

Journal of Virology

Volumn 72, Issue 12, 1998, Pages 9806-9817

  Osterrieder, Nikolaus ^a,b   Neubauer, Antonie ^a,c   Brandmüller, Christine ^a   Kaaden, Oskar Rüger ^a   O'Callaghan, Dennis J ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^c LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIN; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; EQUINE HERPES VIRUS; HERPES VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; VIRUS LOAD; VIRUS NUCLEOCAPSID;

EID: 0031774381     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.12.9806-9817.1998     Document Type: Article

References (31)

1. Allen, G. P., and J. T. Bryans. 1986. Molecular epizootiology, pathogenesis, and prophylaxis of equine herpesvirus-1 infections. Prog. Vet. Microbiol. Immunol. 2:78-144.
2. Breeden, C. A., R. R. Yalamanchili, C. F. Colle, and D. J. O'Callaghan. 1992. Identification and transcriptional mapping of genes encoded at the IR/Us junction of equine herpesvirus type 1. Virology 191:649-660.
3. Colle, C. F., and D. J. O'Callaghan. 1996. Localization of the Us protein kinase of equine herpesvirus type 1 is affected by the cytoplasmic structures formed by the novel IR6 protein. Virology 220:424-435.
4. Elliott, G., and P. O'Hare. 1997. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88:223-233.
5. Flowers, C. C., and D. J. O'Callaghan. 1992. Equine herpesvirus glycoprotein D: mapping of the transcript and a neutralization epitope. J. Virol. 66:6451-6460.
6. Fuchs, E., and K. Weber. 1994. Intermediate filaments: structure, dynamics, function and disease. Annu. Rev. Biochem. 63:345-382.
7. Höger, T. G. Krohne, and J. A. Kleinschmidt. 1991. Interaction of Xenopus lamins LA and LII with chromatin in vitro mediated by a sequence element in the carboxyterminal domain. Exp. Cell Res. 197:280-289.
8. Hübert, P. H., S. Birkenmaier, H. J. Rziha, and N. Osterrieder. 1996. Alterations in the equine herpesvirus type-1 (EHV-1) strain RacH during attenuation. J. Vet. Med. B 43:1-14.
9. Kyhse-Andersen, J. 1984. Electroblotting of multiple gels: a simple apparatus without tank for rapid transfer of proteins from polyacrylamide gels to nitrocellulose. J. Biochem. Biophys. Methods 10:203-210.
10. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
11. Leung Tack, P., J. C. Audonnet, and M. Riviere. 1994. The complete DNA sequence and the genetic organization of the short unique region (US) of the bovine herpesvirus type 1 (ST strain). Virology 199:409-421.
12. Mayr, A., J. Pette, K. Petzoldt, and K. Wagener. 1968. Untersuchungen zur Entwicklung eines Lebendimpfstoffes gegen die Rhinopneumonitis (Stutenabort) der Pferde. J. Vet. Med. B 15:406-418.
13. Mumford, J. A., D. A. Hannant, D. M. Jessett, T. O'Neill, K. C. Smith, and E. N. Ostlund. 1995. Abortigenic and neurological disease caused by experimental infection with equid herpesvirus-1, p. 261-275. In H. Nakajima and W. Plowright (ed.), Proceedings, 7th International Conference of Equine Infectious Diseases. R&W Publications, Newmarket, United Kingdom.
14. Nagesha, H. S., B. S. Crabb, and M. J. Studdert. 1993. Analysis of the nucleotide sequence of five genes at the left end of the unique short region of the equine herpesvirus 4 genome. Arch. Virol. 128:143-154.
15. Neubauer, A., B. Braun, C. Brandmüller, O.-R. Kaaden, and N. Osterrieder. 1997. Analysis of the contributions of the equine herpesvirus 1 glycoprotein gB homolog to virus entry and direct cell-to-cell spread. Virology 227:281-294.
16. Nigg, E. A. 1992. Assembly-disassembly of the nuclear lamina. Curr. Opin. Cell Biol. 4:105-109.
17. O'Callaghan, D. J., C. F. Colle, C. C. Flowers, R. H. Smith, J. N. Benoit, and C. A. Bigger. 1994. Identification and initial characterization of the IR6 protein of equine herpesvirus 1. J. Virol. 68:5351-5364.
18. O'Callaghan, D. J., G. A. Gentry, and C. C. Randall. 1983. The equine herpesvirus, p. 215-318. In B. Roizman (ed.), The herpesvirus. Plenum Publishing Corporation, New York, N.Y.
19. Osterrieder, N., V. R. Holden, C. Brandmüller, A. Neubauer, O.-R. Kaaden, and D. J. O'Callaghan. 1996. The equine herpesvirus 1 IR6 protein is nonessential for virus growth in vitro and modified by serial virus passage in cell culture. Virology 217:442-451.
20. Osterrieder, N., A. Neubauer, C. Brandmüller, O.-R. Kaaden, and D. J. O'Callaghan. 1996. The equine herpesvirus 1 IR6 protein influences virus growth at elevated temperature and is a major determinant of virulence. Virology 226:243-241.
21. Osterrieder, N., R. Wagner, C. Brandmüller, P. Schmidt, H. Wolf, and O.-R. Kaaden. 1995. Protection against EHV-1 challenge infection in the murine model after vaccination with various formulations of recombinant glycoprotein gp14 (gB). Virology 208:500-510.
22. Osterrieder, N., and A. Neubauer. 1998. Unpublished observations.
23. Perdue, M. L., J. C. Cohen, M. C. Kemp, C. C. Randall, and D. J. O'Callaghan. 1975. Characterization of three species of nucleocapsids of equine herpes virus type 1 (EHV-1). Virology 64:187-204.
24. Perdue, M. L., J. C. Cohen, C. C. Randall, and D. J. O'Callaghan. 1976. Biochemical studies of the maturation of herpesvirus nucleocapsid species. Virology 74:194-208.
25. Peter, M., J. Nakagawa, M. Doree, J. C. Labbe, and E. A. Nigg. 1990. In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase. Cell 61:591-602.
26. Remond, M., P. Sheldrick, F. Lebreton, P. Nardeux, and T. Foulon. 1996. Gene organization in the UL region and inverted repeats of the canine herpesvirus genome. J. Gen. Virol. 77:37-48.
27. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
28. Schmidt, M., M. Tschödrich-Rotter, R. Peters, and G. Krohne. 1994. Properties of fluorescently labeled Xenopus lamin A in vivo. Eur. J. Cell Biol. 65: 70-81.
29. Sun, Y., A. R. MacLean, and S. M. Brown. 1995. Identification and characterization of the protein product of gene 67 in equine herpesvirus type 1 strain Ab4. J. Gen. Virol. 76:541-550.
30. Telford, E. A. R., M. S. Watson, K. McBride, and A. J. Davison. 1992. The DNA sequence of equine herpesvirus-1. Virology 189:304-316.
31. Telford, E. A. R., M. S. Watson, J. Perry, A. A. Cullinane, and A. J. Davison. 1998. The DNA sequence of equine herpesvirus-4. J. Gen. Virol. 79:1197-1203.