Directional gene silencing induced by a complex subtelomeric satellite from Drosophila

Chromosoma

Volumn 107, Issue 5, 1998, Pages 311-320

  Kurenova, Elena ^a   Champion, Larry ^a   Biessmann, Harald ^b   Mason, James M ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SATELLITE DNA;

ANIMAL TISSUE; ARTICLE; CENTROMERE; CHROMOSOME 2; DROSOPHILA; NONHUMAN; REPORTER GENE; SILENCER GENE; TELOMERE; TRANSCRIPTION REGULATION; TRANSPOSON; Y CHROMOSOME;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ATP-BINDING CASSETTE TRANSPORTERS; CENTROMERE; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA TRANSPOSABLE ELEMENTS; DNA, SATELLITE; DROSOPHILA; DROSOPHILA PROTEINS; EYE COLOR; EYE PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GENES, SUPPRESSOR; HOMOZYGOTE; IN SITU HYBRIDIZATION, FLUORESCENCE; INSECT PROTEINS; INTERSPERSED REPETITIVE SEQUENCES; MALE; REGULATORY SEQUENCES, NUCLEIC ACID; TELOMERE; TRANSGENES;

ANIMALIA; ARACHNIDA; HEXAPODA;

EID: 0031774102     PISSN: 00095915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004120050313     Document Type: Article

References (62)

1. Baksa K, Morawietz H, Dombrádi V, Axton M, Taubert H, Szabó G, Török I, Udvardy A, Gyurkovics H, Szöör B, Glover D, Reuter G, Gausz J (1993) Mutations in the protein phosphatase 1 gene at 87B can differentially affect suppression of position-effect variegation and mitosis in Drosophila melanogaster. Genetics 135:117-125
2. Belyaeva ES, Demakova OV, Umbetova GH, Zhimulev IF (1993) Cytogenetic and molecular aspects of position-effect variegation in Drosophila melanogaster. V. Heterochromatin-associated protein HP1 appears in euchromatic chromosomal regions that are inactivated as a result of position-effect variegation. Chromosoma 102:583-590
3. Biessmann H, Mason JM, Ferry K, d'Hulst M, Valgeirsdottir K, Traverse KL, Pardue ML (1990) Addition of telomere-associated HeT DNA sequences "heals" broken chromosome ends in Drosophila. Cell 61:663-673
4. Biessmann H, Valgeirsdottir K, Lofsky A, Chin C, Ginther B, Levis RW, Pardue ML (1992) HeT-A, a transposable element specifically involved in healing broken chromosome ends in Drosophila melanogaster. Mol Cell Biol 12:3910-3918
5. Biessmann H, Donath J, Walter MF (1996) Molecular characterization of the Anopheles gambiae 2L telomeric region via an integrated transgene. Insect Mol Biol 5:11-20
6. Cenci G, Rawson RB, Belloni G, Castrillon DH, Tudor M, Petrucci R, Goldberg ML, Wasserman SA, Gatti M (1997) UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior. Gene Develop 11:863-875
7. Csink AK, Henikoff S (1996) Genetic modification of heterochromatic association and nuclear organization in Drosophila. Nature 381:529-531
8. Danilevskaya ON, Arkhipova IR, Traverse KL, Pardue ML (1997) Promoting in tandem: the promoter for telomere transposon HeT-A and implications for the evolution of retroviral LTRs. Cell 88:647-655
9. Dernburg AF, Sedat JW, Cande WZ, Bass HW (1995) Cytology of telomeres. In: Blackburn EH, Greider CW (eds) Telomeres. Cold Spring Harbor Press, Cold Spring Harbor pp 295-338
10. Dernburg AF, Broman KW, Fung JC, Marshall WF, Philips J, Agard DA, Sedat JW (1996) Perturbation of nuclear architecture by long-distance chromosome interactions. Cell 85:745-759
11. Dorer DR, Henikoff S (1994) Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell 77:993-1002
12. Dorer DR, Henikoff S (1997) Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and trans. Genetics 147:1181-1190
13. Dorn R, Heymann S, Lindigkeit R, Reuter G (1986) Suppressor mutation of position-effect variegation in Drosophila melanogaster affecting chromatin properties. Chromosoma 93:398-403
14. Eberl DF, Duyf BJ, Hilliker AJ (1993) The role of heterochromatin in the expression of a heterochromatic gene, the rolled locus of Drosophila melanogaster. Genetics 134:277-292
15. Eissenberg JC, Morris GD, Reuter G, Hartnett T (1992) The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation. Genetics 131:345-352
16. + gene of Drosophila by P-factor-mediated transformation. EMBO J 3:2077-2085
17. Georgiev PG, Gerasimova TI (1989) Novel genes influencing the expression of the yellow locus and mdg4 (Gypsy) in Drosophila melanogaster. Mol Gen Genet 220:121-126
18. Georgiev P, Kozycina M (1996) Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations. Genetics 142:425-436
19. Gerasimova TI, Gdula DA, Gerasimov DV, Simonova O, Corces VG (1995) A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation. Cell 82:587-597
20. Gilson E, Laroche T, Gasser SM (1993) Telomeres and the functional architecture of the nucleus. Trends Cell Biol 3:128-134
21. Hayashi S, Ruddell A, Sinclair D, Grigliatti T (1990) Chromosomal structure is altered by mutations that suppress or enhance position effect variegation. Chromosoma 99:391-400
22. Hazelrigg T, Levis RW, Rubin GM (1984) Transformation of white locus DNA in Drosophila: dosage compensation, zeste interaction, and position effects. Cell 36:469-481
23. Henikoff S (1981) Position-effect variegation and chromosome structure of a heat shock puff in Drosophila. Chromosoma 83:381-393
24. Henikoff S (1992) Position effect and related phenomena. Curr Opin Genet Dev 2:907-912
25. Howe M, Dimitri P, Berloco M, Wakimoto BT (1995) Cis-effects of heterochromatin on heterochromatic and euchromatic gene activity in Drosophila melanogaster. Genetics 140:1033-1045
26. Karpen GH, Spradling AC (1992) Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by Single-P element insertional mutagenesis. Genetics 132:737-753
27. Levis RW, Ganesan R, Houtchens K, Tolar LA, Sheen FM (1993) Transposons in place of telomeric repeats at a Drosophila telomere. Cell 75:1083-1093
28. Lim JK (1993) In situ hybridization with biotinylated DNA. Drosophila Inform Serv 72:73-77
29. Lis JT, Simon JA, Satton CA (1983) New heat shock puffs and betagalactosidase activity resulting from transformation of Drosophila with an hsp70-lacZ hybrid gene. Cell 35:403-410
30. Locke J, Kotarski MA, Tartof KD (1988) Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effects. Genetics 120:181-198
31. Marlor RL, Parkhurst SM, Corces VG (1986) The Drosophila melanogaster gypsy transposable element encodes putative gene products homologous to retroviral proteins. Mol Cell Biol 6:1129-1134
32. Moehrle A, Paro R (1994) Spreading the silence: epigenetic transcriptional regulation during Drosophila development. Dev Genet 15:478-484
33. Muller HJ (1941) Induced mutations in Drosophila. Cold Spring Harbor Symp Quant Biol 9:151-165
34. O'Hare K, Murphy C, Levis R, Rubin GM (1984) DNA sequence of the white locus of Drosophila melanogaster. J Mol Biol 180:437-455
35. Parkhurst SM, Harrison DA, Remington MP, Spana C, Kelley RL, Coyne RS, Corces VG (1988) The Drosophila su(Hw) gene, which controls the phenotypic effect of the gypsy transposable element, encodes a putative DNA-binding protein. Genes Dev 2:1205-1215
36. Paro R (1990) Imprinting a determined state into the chromatin of Drosophila. Trends Genet 6:416-421
37. Pirrotta V (1995) Chromatin complexes regulating gene expression in Drosophila. Curr Opin Genet Develop 5:466-472
38. Pirrotta V, Bickel S, Mariani C (1988) Developmental expression of the Drosophila zeste gene and localization of zeste protein on polytene chromosomes. Genes Dev 2:1839-1850
39. Pirrotta V, Rastelli L (1994) white gene expression, repressive chromatin domains and homeotic gene regulation in Drosophila. Bioessays 16:549-556
40. Platero JS, Hartnett T, Eissenberg JC (1995) Functional analysis of the chromo domain of HP1. EMBO J 14:3977-3986
41. Qian S, Varjavand B, Pirrotta V (1992) Molecular analysis of the zeste-white interaction reveals a promoter-proximal element essential for distant enhancer-promoter communication. Genetics 131:79-90
42. Rastelli L, Chan CS, Pirrotta V (1993) Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J 12:1513-1522
43. Renauld H, Aparicio OM, Zierath PD, Billington BL, Chhablani SK, Gottschling DE (1993) Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Gene Develop 7:1133-1145
44. Roseman RR, Pirotta V, Geyer PK (1993) The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects. EMBO J 12:435-442
45. Rubin G, Spradling AC (1982) Genetic transformation of Drosophila with transposable element vectors. Science 218:348-353
46. Sabl JF, Henikoff S (1996) Copy number and orientation determine the susceptibility of a gene to silencing by nearby heterochromatin in Drosophila. Genetics 142:447-458
47. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning. A laboratory manual. Cold Spring Harbor. Laboratory Press, Cold Spring Harbor
48. Sandell LL, Gottschling DE, Zakian VA (1994) Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability. Proc Natl Acad Sci USA 91:12061-12065
49. Shaffer CD, Wallrath LL, Elgin SC (1993) Regulating genes by packaging domains: bits of heterochromatin in euchromatin? Trends Genet 9:35-37
50. Sheen FM, Levis RW (1994) Transposition of the LINE-like retrotransposon TART to Drosophila chromosome termini. Proc Natl Acad Sci USA 91:12510-12514
51. Shei GJ, Broach JR (1995) Yeast silencers can act as orientation-dependent gene inactivation centers that respond to environmental signals. Mol Cell Biol 15:3496-3506
52. Spofford JB (1976) Position-effect variegation in Drosophila. In: Ashburner M, Novitski E (eds) The Genetics and Biology of Drosophila 1c Academic Press, London, pp 955-1018
53. Stavenhagen JB, Zakian VA (1994) Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae. Gene Develop 8:1411-1422
54. Dominant by linkage alterations. Genetics 136:559-571
55. Tartof KD, Bremer M (1990) Mechanisms for the construction and developmental control of heterochromatin formation and imprinted chromosome domains. Development (Suppl):35-45
56. Tartof KD, Hobbs C, Jones M (1984) A structural basis for variegating position effects. Cell 37:869-878
57. Tower J, Karpen GH, Craig N, Spradling AC (1993) Preferential transposition of Drosophila P elements to nearby chromosomal sites. Genetics 133:347-359
58. Wakimoto BT, Hearn MG (1990) The effects of chromosome rearrangements on the expression of heterochromatic genes in chromosome 2L of Drosophila melanogaster. Genetics 125:141-154
59. Wallrath LL, Elgin SCR (1995) Position effect variegation in Drosophila is associated with an altered chromatin structure. Gene Develop 9:1263-1277
60. Walter MF, Jang C, Kasravi B, Donath J, Mechler BM, Mason JM, Biessmann H (1995) DNA organization and polymorphism of a wild-type Drosophila telomere region. Chromosoma 104:229-241
61. Wu CT, Howe M (1995) A genetic analysis of the Suppressor 2 of zeste complex of Drosophila melanogaster. Genetics 140:139-181
62. Zink D, Paro R (1995) Drosophila Polycomb-group regulated chromatin inhibits the accessibility of a trans-activator to its target DNA. EMBO J 14:5660-5671