Response of the free alpha-subunit to GnRH distinguishes individuals with 'functional' from those with permanent hypogonadotropic hypogonadism

Hormone Research

Volumn 50, Issue 4, 1998, Pages 212-216

  Mainieri, Alberto Scofano ^a   Viera, José Gilberto H ^a   Elnecave, Regina Helena ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Delayed puberty; Free subunit; Hypogonadotropic hypogonadism

Indexed keywords

FOLLITROPIN; GONADORELIN; GONADOTROPIN; LUTEINIZING HORMONE;

ADOLESCENT; ADULT; ALPHA CHAIN; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FOLLITROPIN BLOOD LEVEL; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; IMMUNOFLUORESCENCE; INTRAVENOUS DRUG ADMINISTRATION; LUTEINIZING HORMONE BLOOD LEVEL; MALE; PRIORITY JOURNAL;

EID: 0031774075     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000023276     Document Type: Article

References (30)

1. Whitcomb RW, Crowley WF Jr: Male hypogonadotropic hypogonadism. Endocrinol Metab Clin North Am 1993;22:125-144.
2. Wood DF, Franks S: Delayed puberty. Br J Hosp Med 1989;41:223-230.
3. Ehrmann DA, Rosenfield RL, Cuttler L, Burstein S, Cara JF, Levitsky LL: A new test of combined pituitary-testicular function using the gonadotropin-releasing hormone agonist nafarelin in the differentiation of gonadotropin deficiency from delayed puberty: Pilot studies. J Clin Endocrinol Metab 1989;69:963-967.
4. Lanes R, Palacios A, Avendano E, Moncada G, Chique G: The metoclopramide test: A useful tool with the luteinizing hormone-releasing hormone test in distinguishing between constitutional delay of puberty and hypogonadotropic hypogonadism. Fertil Steril 1989;52:55-59.
5. Smals AGH, Hermus ARM, Boers GHJ, Pieters GFF, Benraad THJ, Kloppenborg PWC: Predictive value of luteinizing hormone releasing hormone (LHRH) bolus testing before and after 36-hour pulsatile LHRH administration in the differential diagnosis of constitutional delay of puberty and male hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1994;78:602-608.
6. Goji K, Tanikaze S: Comparison between spontaneous gonadotropin concentration profiles and gonadotropin response to low-dose gonadotropin-releasing hormone in prepubertal and early pubertal boys and patients with hypogonadotropic hypogonadism: Assessment by using ultrasensitive, time-resolved immunofluorometric assay. Pediatr Res 1992;31:535-539.
7. Ghai K, Cara JF, Rosenfield RL: Gonadotropin releasing hormone agonist (nafarelin) test to differentiate gonadotropin deficiency from constitutionally delayed puberty in teenage boys - A clinical research center study. J Clin Endocrinol Metab 1995;80:2980-2986.
8. Pierce JG, Parsons TF: Glycoprotein hormones: Structure and function. Annu Rev Biochem 1981;50:465-472.
9. Reichlin S: Neuroendocrinology; in Wilson JD, Foster DW (eds): Williams Textbook of Endocrinology, 8 ed. Philadelphia, Saunders, 1992, pp 135-220.
10. Parker DC, Judd HL, Rossman LG, Yen SC: Pubertal sleep-wake patterns of episodic LH, FSH and testosterone release in twin boys. J Clin Endocrinol Metab 1975;40:1099-1109.
11. Wu FCW, Borrow SM, Nicol K, Elton R, Hunter WM: Ontogeny of pulsatile gonadotrophin secretion and pituitary responsivenss in male puberty in man: A mixed longitudinal and cross-sectional study. J Endocrinol 1989;123:347-359.
12. Winters SJ, Troen P: α-Subunit secretion in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1988;66:338-342.
13. Winters SJ, Troen P: Pituitary glycoprotein hormone α-subunit secretion after thyrotropin-releasing hormone stimulation in normal men and men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1990;70:544-547.
14. Garnier PE, Chaussain JL, Binet E, Schlumberger A, Job JC: Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) on the release of gonadotrophins in children and adolescents. VI. Relations to age, sex and puberty. Acta Endocrinol (Copenh) 1974;77:422-434.
15. Styne DM, Kaplan SL, Grumbach MM: Plasma glycoprotein hormone α-subunit in the neonate and in prepubertal and pubertal children: Effects of luteinizing hormone-releasing hormone. J Clin Endocrinol Metab 1980;50:450-455.
16. Spratt DI, Chin WW, Ridgway EC, Crowley WF Jr: Administration of low dose pulsatile gonadotropin-releasing hormone (GnRH) to GnRH-deficient men regulates free a-subunit secretion. J Clin Endocrinol Metab 1986;62:102-108.
17. Winters SJ, Troen P: Pulsatile secretion of immunoreactive α-subunit in man. J Clin Endocrinol Metab 1985;60:344-348.
18. Lindner J, Rivier JE, Vale WW, Pavlou S: Regulation of pituitary glycoprotein α-subunit secretion after administration of a luteinizing hormone-releasing hormone antagonist in normal men. J Clin Endocrinol Metab 1990;70:1219-1224.
19. 6-luteinizing hormone-releasing hormone microcapsules as treatment of precocious puberty. J Clin Endocrinol Metab 1987;65:946-953.
20. Lemay A, Lourdusamy M: Gonadotrophin releasing hormone agonist suppressive treatment of ovarian function decreases serum LH-α and bioactive LH but maintains elevated levels of LH-α. Clin Endocrinol 1991;34:191-196.
21. Russo EMK, Noguti KO, Portes ES, Vieira JGH: Correlations of serum LH levels measured by an immunofluorometric assay and different maturation parameters in normal boys. Clin Chem 1992;38:946.
22. Vieira JGH, Nishida SK, Lombardi MT, Abucham JF, Kasamatsu TS: Monoclonal antibodies specific for the free alpha subunit of glycoprotein hormones and their use in the development of a sensitive immunofluorometric assay. Braz J Med Biol Res 1995;28:633-636.
23. Wu FCW, Butler GE, Kelnar CJH, Stirling HF, Huhtaniemi I: Patterns of pulsatile luteinizing hormone and follicle-stimulating hormone secretion in prepubertal (midchildhood) boys and girls and patients with idiopathic hypogonadotropic hypogonadism (Kallmann's syndrome): A study using an ultrasensitive time-resolved immunofluorometric assay. J Clin Endocrinol Metab 1991;72:1229-1237.
24. Haavisto AM, Dunkel L, Pettersson K, Huhtaniemi I: LH measurements by in vitro bioassay and a highly sensitive immunofluorometric assay improve the distinction between boys with constitutional delay of puberty and hypogonadotropic hypogonadism. Pediatr Res 1990;27:211-214.
25. Prentice LG, Ryan RJ: LH and its subunit in human pituitary, serum and urine. J Clin Endocrinol Metab 1975;40:303-312.
26. Kourides IA, Landon MB, Huffman BJ, Weintraub BC: Excess free alpha relative to beta subunits of the glycoprotein hormones in normal and abnormal human pituitary glands. Clin Endocrinol 1980;12:407-416.
27. Kaplan SL, Grumbach MM, Aubert ML: α and β glycoprotein hormone subunits (hLH, hFSH, hCG) in the serum and pituitary of human fetus. J Clin Endocrinol Metab 1976;22:455-477.
28. Valk TW, Corley KP, Kelch RP, Marshall JC: Hypogonadotropic hypogonadism: Hormonal responses to low dose pulsatile administration of gonadotropin-releasing hormone. J Clin Endocrinol Metab 1980;51:730-738.
29. Whitcomb RW, O'Dea LS, Finkelstein JS, Heavern DM, Crowley WF Jr: Utility of free alpha-subunit as an alternative neuroendocrine marker of gonadotropin-releasing hormone (GnRH) stimulation of the gonadotropin in the human: Evidence from normal and GnRH-deficient men. J Clin Endocrinol Metab 1990;70:1654-1661.
30. Pralong FP, Paylou SN, Waldstreicher J, Crowley WF Jr, Boepple PA: Defective regulation of glycoprotein free alpha-subunit in males with isolated gonadotropin-releasing hormone deficiency - A clinical research center study. J Clin Endocrinol Metab 1995;80:3682-3688.