Are relatives of patients with multiple HNPCC spectrum tumors at increased risk of cancer?

Gut

Volumn 43, Issue 5, 1998, Pages 664-668

  Brown, S R ^a,b   Finan, P J ^a   Bishop, D T ^b  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Family history; Hereditary non polyposis colorectal cancer; Relative risk

Indexed keywords

ARTICLE; CANCER RISK; COLON CARCINOMA; FAMILY HISTORY; FEMALE; GENETIC SUSCEPTIBILITY; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PEDIGREE ANALYSIS; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR;

EID: 0031774069     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.43.5.664     Document Type: Article

References (19)

1. Lovett E. Family studies in cancer of the colon and rectum. Br J Surg 1976;63:13-18.
2. Ponz de Leon M, Sassatelli R, Sacchetti C, et al. Familial aggregation of tumours in the three-year experience of a population-based colorectal cancer registry. Cancer Res 1989;49:4344-8.
3. Stephenson BM, Finan PJ, Gascoyne J, et al. Frequency of familial colorectal cancer. Br J Surg 1991;78:1162-6.
4. Leach FS, Nicolaides NC, Papadopoulos N, et al. Mutations of a mutS homologue in hereditary colon cancer. Cell 1993;75:1215-25.
5. Liu B, Parsons RF, Hamilton SR, et al. HMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res 1994;54:4590-4.
6. Mary J-L, Bishop T, Kolodner R, et al. Mutation analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development. Hum Mol Genet 1995;3:2067-9.
7. Watson P, Lynch HT. Extracolonic cancer in hereditary nonpolyposis colorectal cancer. Cancer 1993;71:677-85.
8. Hall NR, Finan PJ, Ward B, et al. Genetic, susceptibility to colorectal cancer in patients under 45 years of age. Br J Surg 1994;81:1485-9.
9. Joslin C, Rider L, Round C, eds. Yorkshire Cancer Registry: Report for the year 1991, including cancer statistics for 1984-1988. Leeds: Yorkshire Regional Cancer Organisation, 1992.
10. St John DJB, McDermott FT, Hopper JL, et al. Cancer risk in relatives of patients with common colorectal cancer. Ann Intern Med 1993;118:785-90.
11. Fuchs CS, Giovannucci EL, Colditz GA, et al. A prospective study of family history and the risk of colorectal cancer. N Engl J Med 1994;331:1669-74.
12. Bishop DT, Thomas HJ. The genetics of colorectal cancer. Cancer Surv 1990;9:585-604.
13. Lynch HT, Smyrk T. Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated review. Cancer 1996;78:1149-67.
14. Svendsen LB, Bülow S, Mellemgaard A. Metachronous colorectal cancer in young patients: expression of the hereditary nonpolyposis colorectal cancer syndrome? Dis Colon Rectum 1991;34:790-3.
15. Bailey-Wilson JH, Elston RC, Schuelke GS, et al. Segregation analysis of hereditary nonpolyposis colorectal cancer. Genet Epidemiol 1986;3:27-18.
16. Scapoli C, Ponz de Leon M, Sassatelli R, et al. Genetic epidemiology of hereditary nonpolyposis colorectal cancer syndromes in Modena, Italy: results of a complex segregation analysis. Ann Hum Genet 1994;58:275-95.
17. Vasen HFA, Mecklin J-P, Khan PM. Interval cancers in hereditary nonpolyposis colorectal cancer. Lancet 1995; 345:1183-4.
18. Vasen HFA, Wijnen JT, Menko FH, et al. Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology 1996;110: 1020-7.
19. Houlston RS, Murday V, Haracopos C, et al. Screening and genetic counselling for relatives of patients with colorectal cancer in a family cancer clinic. BMJ 1990;301:366-8.