메뉴 건너뛰기




Volumn 42, Issue 4, 1998, Pages 799-802

TX-1877: Design, synthesis, and biological activities as a BRM- functional hypoxic cell radiosensitizer

Author keywords

Antimetastasis; Biological response modifier; Hypoxic cell radiosensitizer; TX 1877

Indexed keywords

2 NITROIMIDAZOLE ACETAMIDE; 2 NITROIMIDAZOLE DERIVATIVE; BIOLOGICAL RESPONSE MODIFIER; KIN 806; KIN 806 PLUS R; MISONIDAZOLE; RADIOSENSITIZING AGENT; TX 1877; TX 1877 PLUS R; UNCLASSIFIED DRUG;

EID: 0031773926     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(98)00328-9     Document Type: Conference Paper
Times cited : (10)

References (15)
  • 2
    • 0024504773 scopus 로고
    • A phase I/II study of the hypoxic cell sensitizer misonidazole as an adjunct to high fractional dose radiotherapy in patients with unresectable squamous cell carcinoma of the head and neck: A RTOG randomized study (#79-04)
    • Lee D.J., Pajak T.F., Stetz J., Order S.E., Weissberg J.B., Fischer J.J. A phase I/II study of the hypoxic cell sensitizer misonidazole as an adjunct to high fractional dose radiotherapy in patients with unresectable squamous cell carcinoma of the head and neck a RTOG randomized study (#79-04) . Int J Radiat Oncol Biol Phys. 16:1989;465-470.
    • (1989) Int J Radiat Oncol Biol Phys , vol.16 , pp. 465-470
    • Lee, D.J.1    Pajak, T.F.2    Stetz, J.3    Order, S.E.4    Weissberg, J.B.5    Fischer, J.J.6
  • 3
    • 0031105485 scopus 로고    scopus 로고
    • Design, synthesis, and biological activity of anti-angiogenic hypoxic cell radiosensitizer haloacetylcarbamoyl-2-nitroimidazoles
    • Hori H., Jin C.-Z., Kiyono M., Kasai S., Shimamura M., Inayama S. Design, synthesis, and biological activity of anti-angiogenic hypoxic cell radiosensitizer haloacetylcarbamoyl-2-nitroimidazoles. Bioorg Med Chem. 5:1997;591-599.
    • (1997) Bioorg Med Chem , vol.5 , pp. 591-599
    • Hori, H.1    Jin, C.-Z.2    Kiyono, M.3    Kasai, S.4    Shimamura, M.5    Inayama, S.6
  • 5
    • 0026596541 scopus 로고
    • Radiosensitizing, toxicological, and pharmacokinetic properties of hydroxamate analogues of nitroimidazoles as bifunctional radiosensitizers/chemical modifiers
    • Nagasawa H., Bando M., Hori H., Satoh T., Tada T., Onoyama Y., Inayama S. Radiosensitizing, toxicological, and pharmacokinetic properties of hydroxamate analogues of nitroimidazoles as bifunctional radiosensitizers/chemical modifiers. Int J Radiat Oncol Biol Phys. 22:1992;561-564.
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 561-564
    • Nagasawa, H.1    Bando, M.2    Hori, H.3    Satoh, T.4    Tada, T.5    Onoyama, Y.6    Inayama, S.7
  • 7
    • 0005626454 scopus 로고
    • Studies on tumor specific treatment targetting hypoxic cell via radiosensitization and chemical modification
    • In: Shibata S., eds. Tokyo, Japan: Res. Fund. Pharm. Sci.
    • Nagasawa H. Studies on tumor specific treatment targetting hypoxic cell via radiosensitization and chemical modification. In: Shibata S., eds. Advance in pharmaceutical sciences. Vol. 10. Tokyo, Japan: Res. Fund. Pharm. Sci.; 1994. p. 147-159.
    • (1994) Advance in Pharmaceutical Sciences , vol.10 , pp. 147-159
    • Nagasawa, H.1
  • 9
    • 33749000228 scopus 로고
    • A new substituent constant, π, derived form partition coefficients
    • Fujita T., Iwasa J., Hansch C. A new substituent constant, π, derived form partition coefficients. J Am Chem Soc. 86:1964;5175-5180.
    • (1964) J Am Chem Soc , vol.86 , pp. 5175-5180
    • Fujita, T.1    Iwasa, J.2    Hansch, C.3
  • 11
    • 0019434319 scopus 로고
    • An approach to the design and synthesis of mercaptoimidazole derivatives containing oxidized sulfur based on electron affinity sensitization
    • Inayama S., Hori H., Ohsaka T., Mori T., Shibata C. An approach to the design and synthesis of mercaptoimidazole derivatives containing oxidized sulfur based on electron affinity sensitization. Gann (Jpn J Cancer Res). 72:1981;156-159.
    • (1981) Gann (Jpn J Cancer Res) , vol.72 , pp. 156-159
    • Inayama, S.1    Hori, H.2    Ohsaka, T.3    Mori, T.4    Shibata, C.5
  • 12
    • 0016977447 scopus 로고
    • Electron affinic sensitization: VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers
    • Adams G.E., Flockhart I.R., Smithen C.E., Stratford I.J., Wardman P., Watts M.E. Electron affinic sensitization VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers . Radiat Res. 67:1976;9-20.
    • (1976) Radiat Res , vol.67 , pp. 9-20
    • Adams, G.E.1    Flockhart, I.R.2    Smithen, C.E.3    Stratford, I.J.4    Wardman, P.5    Watts, M.E.6
  • 13
    • 0023956968 scopus 로고
    • Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice
    • Kanclerz A., Chapman J.D. Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice. Int J Radiat Oncol Biol Phys. 14:1988;309-316.
    • (1988) Int J Radiat Oncol Biol Phys , vol.14 , pp. 309-316
    • Kanclerz, A.1    Chapman, J.D.2
  • 14
    • 0344534179 scopus 로고    scopus 로고
    • Kochi group. Unpublished work
    • Inomata T. Kochi group. Unpublished work.
    • Inomata, T.1
  • 15
    • 0031418950 scopus 로고    scopus 로고
    • Interaction of swainsonine with lymphoid and highly perfused tissues: A pharmacokinetics explanation for sustained immunomodulation
    • Bowen D., Southerland W.M., Bowen C.D., Hughes D.E. Interaction of swainsonine with lymphoid and highly perfused tissues a pharmacokinetics explanation for sustained immunomodulation . Anticancer Res. 17:1997;4345-4346.
    • (1997) Anticancer Res , vol.17 , pp. 4345-4346
    • Bowen, D.1    Southerland, W.M.2    Bowen, C.D.3    Hughes, D.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.