Synthesis and structure elucidation of some new hydrazones and oxadiazolines: Anticonvulsant activities of 2-(3-acetyloxy-2-naphthyl)-4-acetyl-5-substituted-l,3,4-oxadiazolines

Medical Science Research

Volumn 26, Issue 11, 1998, Pages 755-758

  Dogan, H N ^a  

^a MARMARA UNIVERSITY   (Turkey)

Author keywords

1,3,4 oxadiazolines; Anticonvulsant; Hydrazones

Indexed keywords

HYDRAZONE DERIVATIVE; OXADIAZOLE DERIVATIVE; PENTETRAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROSCOPY;

EID: 0031773681     PISSN: 02698951     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Sah PPT, Peoples SA. Isonicotinyl hydrazones as antitubercular agents and derivatives for identification of aldehydes and ketones. J Am PharmAss Sci 1954; 43:513-524.
2. Hassan E, Al-Ashrmiwi MI, Ahdel-Fattah B. Synthesis and antimicrobial testing of certain oxadiazoline and triaJ.ole derivatives. l'harimt;ie 1983:38:833-835.
3. IsmaielAM.Yousif MY, Metwally MA. El-Kerdawy MM. Syntheses of substituted 3-mercapto-l,2,4-triaJ.oles as potential antimicrobial agents, hid J Client 1984: 238:489-491.
4. Dutta MM, Goswami BN, Kataky JCS. Studies on biologically active heterocycles. Part I. Synthesis and anlifungal activity of some new aroyl hydraJones and 2,5-disubstituted-l,3.4-oxadiazoles. Hetenosyche Chum 1986: 23:793-795.
5. Eisa HM, Tantawy AS, El-Kerdawy MM. Synthesis of certain 2aminoadamantane derivatives as potential antimicrobial agents. Pharmazie 1991: 46:182-184.
6. Mir I, Siddiqui MT. Comrie AM. Antitubereulosis agents. V: a-|5-(5Nitro-2-furyl)-l,3,4-oxadiaJ:ol-2-ylthio]acethydrazide and related compounds. J Pharm Sci 1991 ; 80:548-550.
7. Khalil MA, El-Sayed OA. El-Shamy HA. Synthesis and antimicrobial evaluation of novel oxa(thia)diazolylquinolines and oxa(thia)diazepino [7,6-tj quinoles. Arch Pharm (Weinheim) 1993; 326:489-192.
8. Cesur N, Cesur Z, Ergenç N, Uzun M, Kiraz M, Kasimoglu Ö, Kaya D. Synthesis and antifungal activity of some 2-aryl-3-substituted-4-thiazolidinones. Arch Pharm (Weinheim) 1994; 327:271-272.
9. Raman K, Parmar SS, Salzman SK. Anti-inflammatory activity of substituted 1,3,4-oxadiazoles. J Pharm Sci 1989; 78:999-1002.
10. Kalsi R, Pande K, Bhalla TN, Barthwal JP, Gupta GP, Parmar SS. Antiinflammatory activity of quinazolinofarmazans. J Pharm Sci 1990; 79:317-320.
11. Aboul Wafa OM, El-Metwalli AE. Novel benzo[b]thienylhydrazine and 1,3.4-oxadiazole derivatives as potential antidepressant agents. Arch Pharm (Weinheim) 1992; 325:603-608.
12. Agrawal VK, Gupta TK, Parmar SS. Substituted indole benzylhydrazines as anticonvulsants. J Meet Chem 1972; 15:1000 1001.
13. Parmar SS. Joshi PC. Ali B, Cornatzer WE. Anticonvulsant activity and inhibition of respiration in rat brain homogenutes by substituted oxadiazoles.,J Pluirm Sci 1974; 63:872-875.
14. Parmar SS. Gupta AK. GuptaTK. Slcnbcrg VI. Synthesis of substituted benJ.yldinohydraJines and their monoamine oxida.se inhibitory and anticonvulsam properties..J Pliann Sci 1975: 64:154-157.
15. Chaudhary SK, Kumar S, Parmar SS. Chaudharv M. Anticonvulsant and antiproteolytic properties of'2,5-disubstituted oxadiazoles and their inhibition of respiration in rat brain homogenates. J Pluirm Sci 1978: 67:987-990.
16. Rollas S. Synthesis and speetrometric analysis of some hydraJ.ide hydraJones.,J l-'ac Pluirm Istanbul 1981: 17: 41-50.
17. Ergenc N. Rollas S. Topaloglu Y. Ötük G. Synthesis and characterization of new 1.3.4-oxadiazolines. Arch Pliann tWeinheim) 1989; 322: 837-838.
18. Osonoe K. Mon N, Suzuki K. Osonoe M. Antiepileptic effects of inhibitors of nitric oxide synthase examined in pentylenetetrazoleinduced seizures in rats. Bruin Res 1994; 663:338-340.
19. Kömürcü SG, Rollas S, tilgen M. Gorrod JW, Cevikbas A. Evaluation of some arylhydrazones of p-aminobenzoic acid hydrazide as antimicrobial agents and their in vitro hepatic microsomal metabolism. Roll Chim Farmaceutico 1995; 134:375-379.
20. Ergenç N. Rollas S, Capan G. Dogan N. Özger Y. Studies on azopyrazole derivatives. Part 8: Synthesis and characterization of new l-(l-substituted-3,4-dimethylpyrazolylazo)-N2-(substituted benzylidene)benzohydrazides. Pharmazie 1989; 44:573-574.
21. Durgun B, Çapan G. Ergenç N. Rollas S. Synthesis, characterization and biological evaluation of new benzylidene benJ.ohydrazides and 2.5disubstituted-2.3-dihydro-l,3.4-oxadiazoles. Pharmazie 1993; 48: 942-943.