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Recently, the preparation of several calixarene - carbohydrate structures, called calixsugars, endowed with similar features has been reported. See: a) A. Dondoni, A. Marra, M C. Scherrmann, A. Casnati, F. Sansone, R. Ungaro, Chem. Eur. J. 1997, 3, 1774-1782; b) A. Dondoni, M. Kleban, A. Marra, Tetrahedron Lett. 1997, 38, 7801-7804; c) A. Marra, A. Dondoni, F. Sansone, J. Org. Chem. 1996, 61, 5155-5158; d) S. J. Meunier, R. Roy, Tetrahedron Lett. 1996, 37, 7801-7804; e) A. Marra, M C. Scherrmann, A. Dondoni, A. Casnati, P. Minari, R. Ungaro, Angew. Chem. 1994, 106, 2533; Angew. Chem. Int. Ed. Engl. 1994, 33, 2479-2481.
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The saponification step is cruxial in the synthetic scheme. After treatment of a methanolic solution of the conjugates with sodium methoxyde, a precipitate containing a mixture of partially protected derivatives was formed. Addition of water allowed isolation of the fully unprotected compounds as the sole reaction products.
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59
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The use of fully unprotected sugar isothiocyanate conjugates in the preparation of carbohydrate-coated PAMAM-based dendrimers has recently been reported by Kieburg and Linhorst (c.f. ref. [10b]). A different strategy, using amino sugar conjugates and the amide bond forming methodology, has also been reported (c.f. N. Jayaraman, J. F. Stoddart, Tetrahedron Lett. 1997, 38, 6767-6770).
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2O, 343 K). Since FABMS and microanalytical data agreed with the expected values, an isomerisation reaction, likely at the anomeric center, probably occurred. Since unprotected α-D-mannopyranosylthiourea-coated glycodendrimers have been already reported (c.f., Linhorst et al., refs [10a, c]), this aspect is currently the object of a detailed investigation in collaboration with Dr. Linhorst (Hamburg University, Germany).
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-1 was estimated for the complex Taxotère-19 from extraction experiments at 25 °C.
-
(1995)
Chem. Abstr.
, vol.123
-
-
-
70
-
-
3743057050
-
-
Hemolysis tests were performed by Dr M. Bost at the Hematology Department of the Centre Hospitalier Universitaire de Grenoble. For experimental details, see ref. 12
-
Hemolysis tests were performed by Dr M. Bost at the Hematology Department of the Centre Hospitalier Universitaire de Grenoble. For experimental details, see ref. 12.
-
-
-
-
71
-
-
0002415386
-
-
Y. Li, R. Hunter, R. T. McIver Jr., J. Mass Spectrom. Ion Process. 1996, 157/158, 175-188.
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(1996)
J. Mass Spectrom. Ion Process.
, vol.157-158
, pp. 175-188
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-
Li, Y.1
Hunter, R.2
McIver Jr., R.T.3
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