Metabolic depletion inhibits the uptake of nontransferrin-bound iron by K562 cells

Journal of Cellular Physiology

Volumn 177, Issue 4, 1998, Pages 585-592

  Gutierrez, Jesus A ^a   Inman, Robin S ^a   Akompong, Thomas ^a   Yu, Jianming ^a   Wessling Resnick, Marianne ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFERRIN;

ARTICLE; BILAYER MEMBRANE; CELL STIMULATION; COMPETITIVE INHIBITION; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IRON TRANSPORT; METABOLIC DISORDER; METABOLIC INHIBITION; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; RETICULOCYTE;

EID: 0031772852     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199812)177:4<585::AID-JCP9>3.0.CO;2-Y     Document Type: Article

References (31)

1. Akompong, T., Inman, R.S., and Wessling-Resnick, M. (1995) Phorbol esters stimulate nontransferrin iron uptake by K562 cells. J. Biol. Chem., 270:20937-20941.
2. Avron, M., and Shavit, N. (1963) A sensitive and simple method for determination of ferrocyanide. Anal. Biochem., 6:549-554.
3. De Silva, D.M., Askwith, C.C., and Kaplan, J. (1996) Molecular mechanisms of iron uptake in eukaryotes. Physiol. Rev., 76:31-47.
4. Fleming, M.D., Romano, M.A., Su, M.A., Garrick, L.M., Garrick, M.D., and Andrews, N.C. (1998) Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. USA, 95:1148-1153.
5. Fleming, M.D., Trenor, C.C. III, Su, M.A., Foernzler, D., Beier, D.R., Dietrich, W.F., and Andrews, N.C. (1997) Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nature Genet., 16:383-386.
6. Goldenberg, H., Dodel, B., and Seidl, D. (1990) Plasma membrane Fe2-transferrin reductase and iron uptake in K562 cells are not directly related. Eur. J. Biochem., 192:475-480.
7. Gruenheid, S., Cellier, M., Vidal, S., and Gros, P. (1995) Identification and characterization of a second mouse Nramp gene. Genomics, 25:514-525.
8. Gunshin, H., Mackenzie, B., Berger, U.V., Gunshin, Y., Romero, M.F., Boron, W.F., Nussberger, S., Gollan, J.L., and Hediger, M.A. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature, 388:482-488.
9. Gutierrez, J.A., and Wessling-Resnick, M. (1996) Molecular mechanisms of iron transport. Crit. Rev. Euk. Gene Exp., 6:1-14.
10. Gutierrez, J.A., Yu., J., Rivera, S. and Wessling-Resnick, M. (1997) Functional expression cloning and characterization of SFT, a stimulator of Fe transport. J. Cell Biol., 139:895-905.
11. Higgins, C.F. (1992) ABC transporters: From microorganisms to man. Annu. Rev. Cell Biol., 8:67-113.
12. Higgins, C.F. (1995) The ABC of channel regulation. Cell, 82:693-696.
13. Inman, R.S., and Wessling-Resnick, M. (1993) Characterization of transferrin-independent iron transport in K562 cells: Unique properties provide evidence for multiple pathways of iron uptake. J. Biol. Chem., 268:8521-8528.
14. Inman, R.S., Coughlan, M.M., and Wessling-Resnick, M. (1994) Extracellular ferrireductase activity in K562 cells is coupled to transferrin-independent iron transport. Biochemistry, 33:11850-11857.
15. Jordan, I., and Kaplan, J. (1994) The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity. Biochem. J., 302:875-879.
16. Kammler, M., Schon, C., and Hantke, K. (1993) Characterization of the ferrous iron uptake system of Escherichia coli. J. Bacteriol., 175:6212-6219.
17. Pederson, P.L., and Carafoli, E. (1987) Ion motive ATPases. I. Ubiquity, properties, and significance to cell function. Trends Biol. Sci., 12:146-150.
18. Qian, Z.M., and Morgan, E.H. (1991) Effect of metabolic inhibitors on uptake of non-transferrin-bound iron by reticulocytes. Biochim. Biophys. Acta, 1073:456-462.
19. Quail, E.A., and Morgan, E.H. (1994) Role of membrane surface potential and other factors in the uptake of non-transferrin-bound iron by reticulocytes. J. Cell. Physiol., 159:238-244.
20. Randell, E.W., Parkes, J.G., Olivieri, N.F., and Templeton, D.M. (1994) Uptake of nontransferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron. J. Biol. Chem., 269:16046-16053.
21. Riedel, H.-D., Remus, A.J., Fitscher, B.A., and Stremmel, W. (1995) Characterization and partial purification of a ferrireductase from human duodenal microvillous membranes. Biochem. J., 309:745-748.
22. Schweinzer, E., and Goldenberg, H. (1992) Ascorbate-mediated transmembrane electron transport and ascorbate uptake in leukemic cell lines are two different processes. Eur. J. Biochem., 206:807-812.
23. Schweinzer, E., and Goldenberg, H. (1993) Monohydroascorbate reductase activity in the surface membrane of leukemic cells: Characterization by a ferricyanide-driven redox cycle. Eur. J. Biochem., 218:1057-1062.
24. Stearman, R., Yuan, D.S., Yamaguchi-Iwai, Y., Klausner, R.D., and Dancis, A. (1996) A permease-oxidase complex involved in high-affinity iron uptake in yeast. Science, 271:1552-1557.
25. +2 antiport. Biochim. Biophys. Acta, 1282:163-170.
26. Teichmann, R., and Stremmel, W. (1990) Iron uptake by human upper small intestine microvillous membrane vesicles: Indication for a facilitated transport mechanism mediated by a membrane iron-binding protein. J. Clin. Invest., 86:2145-2153.
27. Trikha, J., Theil, B.C., and Allewell, N.M. (1995) High resolution crystal structures of amphibian red-cell L ferritin: Potential roles for structural plasticity and solvation in function. J. Mol. Biol., 248:949-967.
28. Vulpe, C., Levinson, B., Whitney, S., Packman, S., and Gitschier, J. (1993) Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase. Nature Genet., 3:7-13.
29. Wright, T.L., Fitz, J.G., and Weisiger, R.A. (1988) Non-transferrin-bound iron uptake by rat liver: Role of membrane potential difference. J. Biol. Chem., 263:1842-1847.
30. Yu, J., and Wessling-Resnick, M. (1998a) Influence of copper depletion on iron uptake mediated by SFT, a stimulator of Fe transport. J. Biol. Chem., 273:6909-6915.
31. Yu, J., and Wessling-Resnick, M. (1998b) Structural and functional analysis of SFT, a stimulator of Fe transport. J. Biol. Chem. (in press).