Induction of iNOS gene expression by monophosphoryl lipid A: A pharmacological approach for myocardial adaptation to ischemia

Drugs under Experimental and Clinical Research

Volumn 24, Issue 3, 1998, Pages 117-124

  Maulik, N ^a   Tosaki, A ^a   Elliott, G T ^b   Maulik, G ^a   Das, D K ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ENZYME; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHORYL LIPID A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA FLOW; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENZYME INDUCTION; GENE INDUCTION; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; INTRAPERITONEAL DRUG ADMINISTRATION; MACROPHAGE; MALE; NONHUMAN; NORTHERN BLOTTING; RAT; REPERFUSION INJURY; RNA ANALYSIS; STRESS;

ANIMALS; BLOTTING, NORTHERN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIPID A; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, MESSENGER;

EID: 0031772684     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Reimer K.A., van der Heide R.S., Jennings R.B. Ischemic preconditioning slows ischemic metabolism and limits myocardial infarct size. Ann. N.Y Acad. Sci., 723, 99, 1994.
2. Li G.C., Vasquez B.S., Gallagher K.P., Lucchesi B.R. Myocardial protection with preconditioning. Circulation, 82, 609, 1990.
3. Lawson C.S., Coltart D.J., Hearse D.J. The antiarrhythmic action of ischemic preconditioning in rat hearts does not involve functional Gi proteins. Cardiovasc. Res., 27, 681, 1993.
4. Kimura Y., Iyengar J., Subramanian R., Cordis G.A., Das D.K. Preconditioning of heart by repeated stunning: attenuation of post-ischemic dysfunction. Basic Res. Cardiol., 87, 128, 1992.
5. Flack J., Kimura Y., Engelman R.M., Das D.K. Preconditioning the heart by repeated stunning improves myocardial salvage. Circulation, 84 (Suppl. III), 369, 1991.
6. Tosaki A., Cordis G.A., Szerdahelyi P., Engelman R.M., Das D.K. Effects of preconditioning on reperfusion arrhythmias, myocardial functions, formation of free radicals, and ion shifts in isolated ischemic perfused rat hearts. J. Cardiovasc. Pharm., 23, 365, 1994.
7. Liu G.S., Thornton J., Van Winkle D.M., Stanley A.W.H., Olsson R.A., Downey J.M. Protection against infarction afforded by preconditioning is mediated by A1 receptor in rabbit heart. Circulation, 84, 350, 1991.
8. Gross G.J., Yao Z., Pieper G.M., Auchampach J.A. The ATP-regulated potassium channel in ischemia-reperfusion injury. Ann. N.Y. Acad. Sci., 723, 71, 1994.
9. Liu X., Engelman R.M., Moraru I., et al. Heat shock: a new approach for myocardial preservation in cardiac surgery. Circulation, 86 (Suppl. 2), 358, 1992.
10. Maulik N., Watanabe M., Engelman D., Engelman R.M., Das D.K. Oxidative stress adaptation improves postischemic ventricular recovery. Mol. Cell Biochem., 144, 67, 1995.
11. Maulik N., Engelman R.M., Wei Z., et al. Drug-induced heat shock improves post-ischemic ventricular recovery after cardiopulmonary bypass. Circulation, 92 (Suppl. II), 381, 1995.
12. Elliott G.T. Pharmacologic myocardial preconditioning with monophosphoryl lipid A (MLA) reduces infarct size and stunning in dogs and rabbits. Ann. N.Y. Acad. Sci., 793, 386, 1996.
13. Brown J.M., Grosso M.A., Terada L.S., et al. Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Natl. Acad Sci. U.S.A., 86, 2516, 1989.
14. Maulik N., Watanabe M., Engelman D., et al. Myocardial adaptation to ischemia by oxidative stress induced by endotoxin. Am. J. Physiol., 269, C908, 1995.
15. Yao Z., Elliott G.T., Gross G.J. Monophosphoryl lipid A (MLA) preserves myocardial contractile function following multiple, brief periods of coronary occlusion in dogs. Pharmacology, 51, 152, 1995.
16. Zhao L., Kirsch C.C., Hagen S.R., Elliott G.T. Preservation of global cardiac function in the rabbit following protected ischemia/reperfusion using monophosphoryl lipid A (MLA). J. Mol. Cell Cardiol., 28, 197, 1996.
17. Yao Z., Auchampach J.A., Pieper G.M., Gross G. Cardio-protective effects of monophosphoryl lipid A, a novel endotoxin analogue, in the dog. Cardiovasc. Res., 27, 832, 1993.
18. Fast D.J., Lynch R.C., Leu R.W., Interferon-γ, but not interferon-αβ, synergizes with tumor necrosis factor-α and lipid A in the induction of nitric oxide production by murine L929 cells. J. Interferon Res., 13, 271, 1993.
19. Marczin N., Papapetropoulos A., Catravas J.D. Tyrosine kinase inhibitors suppress endotoxin-and IL-1b induced NO synthesis in aortic smooth muscle cells. Am. J. Physiol., 265, H1014, 1993.
20. Maulik N., Watanabe M., Engelman D.T., et al. Nitric oxide attenuates myocardial ischemia reperfusion injury by functioning as synchronizing messenger with carbon monoxide and intracellular antioxidant. Surg. Forum, 47, 230, 1996.
21. Maulik N., Engelman D.T., Watanabe M., et al. Nitric oxide/carbon monoxide: a molecular switch for myocardial preservation during ischemia. Circulation, 94 (Suppl. II), 398, 1996.
22. Zhao L., Weber P.A., Smith J.R., Comerford M.L., Elliott G.T. Role of inducible nitric oxide synthase (iNOS) in pharmacological "preconditioning" with monophosphoryl lipid A. J. Mol. Cell Cardiol., (in press).
23. Zhao L., Weber P.A., Comerford M.L., Smith J.R., Kehl J., Elliott G.T. Role of inducible nitric oxide synthase (iNOS) in "pharmacological preconditioning" with monophosphoryl lipid A. Circulation (Suppl. I), 94, I-422, 1996.
24. Tosaki A., Braquet P. DMPO and reperfusion injury: arrhythmia, heart function, electron spin resonance, and nuclear magnetic resonance studies in isolated working guinea pig hearts. Am. Heart J., 120, 819, 1990.
25. Tosaki A., Hellegouarch A. Adenosine triphosphate-sensitive potassium channel blocking agent ameliorates, but the opening agent aggravates, ischemia/reperfusion-induced injury: heart function studies in nonfibrillating isolated hearts. J. Am. Coll. Cardiol., 23, 487, 1994.
26. Hearse D.J., Tosaki A. Free radicals and repertusion-induced arrhythmias: protection by spin trap agent PBN in the rat heart. Circ. Res., 60, 375, 1987.
27. Maulik N., Engelman R.M., Zongie W., Lu D., Rousou J.A., Das D.K. Interleukin-1α preconditioning reduces myocardial ischemia reperfusion injury. Circulation, 88, 387, 1993.
28. Traylor L.A., Proksch J.W., Beanum V.C., Mayeux P.R. Nitric oxide generation by renal proximal tubules: role of nitric oxide in the cytotoxicity of lipid A. J. Pharmacol. Exp. Ther., 279, 91, 1996.
29. Rees D.D., Cellek S., Palmer M.J., Moncada S. Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock. Biochem. Biophys Res Commun., 173, 541, 1990.
30. Fleming I., Gray G.A, Julou-Schaeffer G., Parratt J.R. Incubation with endotoxin activates the L-arginine pathway in vascular tissue. Biochem Biophys. Res Commun., 171, 562, 1990.
31. Martin E.C., Nathan C., Xie Q. Role of interferon regulatory factor I in induction of nitric oxide synthase. J. Exp. Med., 180, 977, 1994.
32. Mayeux P.R., Garner H.R., Gibson J.D., Beanum V.C. Effect of lipopolysaccharide on nitric oxide synthase activity in rat proximal tubules. Biochem. Pharmacol., 49, 115, 1995.
33. Maulik N., Engelman D.T., Watanabe M., et al. Nitric oxide signaling in ischemic heart. Cardiovasc. Res., 30, 593, 1995.
34. Maulik N., Engelman D.T., Watanabe M., Engelman R.M., Das D.K. Nitric oxide - a retrograde messenger for carbon monoxide signaling in ischemic heart. Mol. Cell Biochem., 157, 75, 1996.
35. Engelman D.T., Watanabe M., Maulik N., et al. L-arginine reduces endothelial inflammation and myocardial stunning during ischemia/reperfusion. Ann. Thorac. Surg., 60, 1275, 1995.
36. Weyrich A.S., Ma X., Lefer A.M. The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat. Circulation, 86, 279, 1992.
37. Nakanishi K., Vinten-Johansen J., Lefer D.J., et al. Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size. Am. J. Physiol., 263, H1650, 1992.
38. Qureshi N., Takayama K., Ribi E. Purification and structural determination of nontoxic lipid A obtained from lipopolysaccharide of Salmonella typhimurium. J. Biol. Chem., 257, 11808, 1982.